2021
DOI: 10.1186/s40798-021-00307-9
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Exercise and Neuropathic Pain: A General Overview of Preclinical and Clinical Research

Abstract: Neuropathic pain is a disease of the somatosensory system that is characterized by tingling, burning, and/or shooting pain. Medication is often the primary treatment, but it can be costly, thus there is an interest in understanding alternative low-cost treatments such as exercise. The following review includes an overview of the preclinical and clinical literature examining the influence of exercise on neuropathic pain. Preclinical studies support the hypothesis that exercise reduces hyperalgesia and allodynia… Show more

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Cited by 48 publications
(44 citation statements)
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References 106 publications
(199 reference statements)
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“…Upon reviewing the literature, there is support that exercise-based interventions ≥4 weeks are beneficial for patients with DPN. This conclusion falls in line with other recently conducted literature reviews investigating the effects of exercise on enhancing gait function [ 156 ], decreasing neuropathic pain [ 157 ], and improving posture and balance among patients with peripheral neuropathy [ 158 ]. However, though the results of this review find various modalities of exercise to be beneficial, the effects are quite numerous and at times, inconsistent.…”
Section: Discussionsupporting
confidence: 91%
“…Upon reviewing the literature, there is support that exercise-based interventions ≥4 weeks are beneficial for patients with DPN. This conclusion falls in line with other recently conducted literature reviews investigating the effects of exercise on enhancing gait function [ 156 ], decreasing neuropathic pain [ 157 ], and improving posture and balance among patients with peripheral neuropathy [ 158 ]. However, though the results of this review find various modalities of exercise to be beneficial, the effects are quite numerous and at times, inconsistent.…”
Section: Discussionsupporting
confidence: 91%
“…Based on that finding, increase of endocannabinoids by voluntary forelimb exercise may suppress the phenotypic switch of primary sensory neurons induced by limb immobilization. Meanwhile, it is well known that exercise may facilitate upregulation of neurotrophic proteins (e.g., brain-derived neurotrophic factor, neurotrophin) in damaged pain sensory neurons [ 28 ]. A previous study demonstrated that exercises for hindlimb of spinal cord injury rats significantly increase the levels of neurotrophin-3 (NT-3) and NT-4 in lumbar and thoracic spinal cord [ 29 ].…”
Section: Discussionmentioning
confidence: 99%
“…Chemotherapy-induced increases in intracellular reactive oxygen species (ROS) contribute to nerve degeneration via mitochondrial dysfunction and apoptosis, as well as demyelination due to damage to phospholipids. In response to peripheral nerve damage, Schwann cells, satellite cells in the dorsal root ganglion, and astrocytes and microglia in the spinal cord, release pro-inflammatory mediators such as tumor necrosis factor-Alpha (TNF-A), interleukin-1Beta (IL-1B), IL-6, and IL-8 ( Brandolini et al, 2019; Leitzelar and Koltyn, 2021; Costigan et al, 2009 ). These cytokines lead to neuronal damage both directly through receptor-mediated pathways and indirectly by inciting macrophage recruitment and accumulation ( Brandolini et al, 2019 ).…”
Section: Proposed Mechanisms For Exercise’s Potential Benefit In Reducing Cipn and Improving Sleepmentioning
confidence: 99%
“…These cytokines lead to neuronal damage both directly through receptor-mediated pathways and indirectly by inciting macrophage recruitment and accumulation ( Brandolini et al, 2019 ). Along with altered neurotrophic signaling by activated microglia, pro-inflammatory cytokines also change neuronal function and increase nociceptive excitability, contributing to hyperalgesia and allodynia ( Costigan et al, 2009; Leitzelar and Koltyn, 2021; Scheffer and Latini, 2020 ).…”
Section: Proposed Mechanisms For Exercise’s Potential Benefit In Reducing Cipn and Improving Sleepmentioning
confidence: 99%
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