Individuals with obesity have reduced activity levels and increased incidence of knee arthritis and pes planus. Foot orthoses can affect lower-limb alignment to reduce pain in nonobese individuals. Evidence to support using foot orthoses for obese people, although often recommended, remains lacking. This pilot study determined the feasibility of prescribing foot orthoses for obese people; effect sizes for calculation of future sample sizes; and relationships among foot orthoses use, physical activity, and functional level. This repeated-measures study included nine people with obesity (body mass index [BMI] Q 30 kg/m 2 ) prescribed with semicustom foot orthoses using arch classifications derived from arch index values. Self-reported data collected at baseline and 1 year were used to determine relationships among foot orthoses use, physical activity, and functional levels. Eight of nine subjects adhered to the foot orthoses prescription. Rate of foot orthoses use and physical activity level as self-reported on the Physical Activity Level (PAL) scale significantly increased, whereas functional level did not. Effect sizes ranged from large for PAL to small for the Lower Extremity Functional Scale (LEFS). Changes in ability to walk a mile were strongly associated with changes in rate of foot orthoses use and reductions in BMI. Larger studies to determine the effect of physical activity and foot orthoses use in obese people are warranted. (J Prosthet Orthot. 2014;26:216Y219.)KEY INDEXING TERMS: foot orthoses, exercise, obesity, patient compliance, weight reduction programs O besity has been associated with the incidence of orthopedic disorders such as pes planus, knee malalignment, and osteoarthritis. 1Y3 Compared with healthy-weight individuals, people with obesity were twice as likely to have chronic pain and severely obese people were four times as likely to have chronic pain. 4 Lower-quarter pain may be linked through the interrelated joint alignments of the foot, knee, and lower kinetic chain. 5 For instance, pes planus has occurred with lower-limb dysfunction and was correlated with osteoarthritis-related knee pain in people with obesity. 6 Obese individuals were 2.7 times more likely to have pes planus and 3.2 times more likely to have knee osteoarthritis than nonobese people. 7,8 Once knee malalignment has developed, the progression increased with each 2-unit body mass index (BMI) increase. 9 Foot orthoses have altered the alignment and biomechanics of the foot and the ankle, 10 the lower leg, 5 the knee, 11 the hip, and the pelvis. 12 Such biomechanical changes may explain observed reductions in back, 13 knee arthritis, 14 and foot pain 15 in nonobese individuals. Because reduced physical activity and functional levels associated with obesity may be associated with orthopedic conditions, 16 foot orthoses have been recommended within the conservative care for people with obesity. 17 However, limited evidence supports using foot orthoses to increase physical activity level in people with obesity or to reduce or...