Exercise and the Gallbladder

Physical Activity and the Risk of Gallbladder Disease: A Systematic Review and Meta-Analysis of Cohort Studies

“…We assessed a 22 potential nonlinear dose-response relationship between physical activity and gallbladder 23 disease using fractional polynomial models. 31 We determined the best fitting second order 24 fractional polynomial regression model, defined as the one with the lowest deviance. A likelihood ratio test was used to assess the difference between the nonlinear and linear models 1 to test for nonlinearity.…”

“…High versus low analysis 7 Eight cohort studies [19][20][21][22][23][24][25][26] investigated the association between physical activity and 8 gallbladder disease risk ( Table 1). The summary relative risk for high versus low physical when we restricted the analysis to studies with ≥500 cases, p=0.14, and the results were respectively, with a steeper inverse association at higher levels of vigorous physical activity, 16 while the association for non-vigorous physical activity was less pronounced at higher levels Table 2).…”

“…We identified 8 cohort studies that could be included in the analysis of physical activity and 3 gallbladder disease [19][20][21][22][23][24][25][26] , with a total of 6958 cases and 218204 participants ( Figure 1, Table 4 1). Seven of the studies were from North-America and one was from Europe.…”

“…High versus low analysis 7 Eight cohort studies [19][20][21][22][23][24][25][26] investigated the association between physical activity and 8 gallbladder disease risk ( Table 2). …”

“…Case-control study (2)(3)(4)(5) Cross-sectional study (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) Gallstones in pregnancy (21)(22)(23) Letter/editorial/news/note/comment (24)(25)(26)(27)(28)(29)(30) Meta-analysis No protocol Eligibility criteria 6 Specify study characteristics (e.g., PICOS, length of follow-up) and report characteristics (e.g., years considered, language, publication status) used as criteria for eligibility, giving rationale.…”