Exercise as Medicine in the Management of Pancreatic Cancer

Cormie, Prue; Spry, Nigel; Jasas, Kevin; Johansson, Mikael; Yusoff, Ian F.; Newton, Robert U.; Galvão, Daniel A.

doi:10.1249/mss.0000000000000160

Cited by 29 publications

(102 citation statements)

References 38 publications

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“…These beneficial impacts possibly contributed to the patient's tolerance to the medical therapy. Also, the results confirm the findings of the case study from Cormie et al that showed positive effects of an exercise program to manage a stage II pancreatic cancer patient [15]. But in contrast to Cormie et al, this case study investigated intense exercise in an advanced, metastatic pancreatic cancer patient under palliative treatment, what provides additional and new data.…”

Section: Resultssupporting

confidence: 85%

“…Cormie et al showed in a first case study, that a pancreatic cancer patient (T2 N1 M0 stage 2b) under adjuvant chemotherapy and three months after surgery was able to perform an intense exercise program for seven months. Additionally to the feasibility, the program had a positive impact on the patient's QoL, the cancer-related fatigue and depression and anxiety symptoms [15].…”

Section: Introductionmentioning

confidence: 99%

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Exercise Improves Patient Outcomes in Advanced Pancreatic Cancer Patient During Medical Treatment

Niels¹,

Tomanek²,

Schneider³

et al. 2018

Pancreat Disord Ther

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Introduction: Advanced pancreatic cancer is still a major challenge in patients' treatment and is associated with poor prognoses and quality of life. Exercise seems to be a feasible and efficient approach to support the medical therapy in many cancer patients. This case study reports about the impacts of high intensity exercise in an advanced pancreatic cancer patient. Method: The 46y-old male patient was diagnosed with a stage IV pancreatic cancer and received a palliative chemotherapy for two months, a neoadjuvant chemotherapy for three months (both FOLIFIRINOX), a surgery and an adjuvant chemotherapy (Gemcitabine) for another two months. During the whole medical treatment, the patient performed a high intensity resistance and endurance exercise program twice a week. Data regarding body weight, physical performance, physical activity, fatigue, depression and anxiety and quality of life were measured at baseline, three and seven months after the exercise program started. Results: The exercise program was well tolerated and feasible. The patient mostly maintained his body weight (-2,3%) and improved his physical performance despite chemotherapy and surgery. The patient's medical treatment protocol was changed from palliative to neoadjuvant during the exercise period. Additionally, self-reported quality of life and depression and anxiety values improved during the exercise program. Declines were noticed in the patient's regular physical activity, but still exceeded the international recommendations. Conclusion: This first case study suggests the feasibility and efficacy of high intensity exercise in an advanced pancreatic cancer patient during medical treatment. Moreover, the exercise program led to clinically relevant improvements in physical and psychological patient outcomes, which may benefit the patient's tolerance to the medical treatment. Further research should verify these results in randomized-controlled trails and focus on the dose-response relation of exercise.

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Section: Resultssupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Exercise Improves Patient Outcomes in Advanced Pancreatic Cancer Patient During Medical Treatment

Niels¹,

Tomanek²,

Schneider³

et al. 2018

Pancreat Disord Ther

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“…He has a 19 year history of chronic pancreatitis. No mention of the patient's family medical history 108 . Case report 2 has a total score of "355" which indicates this patient has a moderate risk of developing pancreatic cancer.…”

Section: Case Reportmentioning

confidence: 99%

Clinical decision support system as a risk assessment tool to aid in earlier diagnosis of pancreatic cancer

Adams

Mital

Mehta

2017

IJMEI

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Introduction to the Problem…………………………………………………….…1 1.2 Background and Statement of the Problem……………………………….….…..8 1.3 Significance of the Study…………………………………………………….……13 1.4 Research Goals and Objectives....……………………….………………….…….15 1.5 Research Hypotheses…………………………………………….…………….…..16

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“…However very little data exists exploring the potential impact of exercise in pancreatic-cancer patients despite the need to counteract commonly experience adverse effects including significant weight-loss, cancerrelated fatigue, nausea, and psychological distress [2,3,7]. In 2014, a study reported a case study involving a 49-yr old man with pancreaticcancer [8]. The exercise intervention included twice a week sessions of moderate-to-high intensity resistance and aerobic-training for 6 months.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Response to Exercise in a Pancreatic-cancer Patient: a Case Report

Pedrinolla¹,

Ardigò²,

Salvagno³

et al. 2016

Pancreat Disord Ther

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adults, high intensity and/or prolonged-exercise leads to muscle and other tissue-damage causing an increased inflammatory-response, involving several types of blood cells and pro-inflammatory cytokines [9]. During prolonged-exercise, the pattern of inflammatoryresponse is different from the response to other kind of stress (e.g., hyperthermia, hemorrhagic-shock). Furthermore, even when same cytokines (e.g., interleukin-6, interleukin-10, MCP-1) are activated during both exercise and in cancer environment, they may have different function and trigger different mechanisms (Table 1). In fact, the response to prolonged-exercise is featured by a marked elevation in circulating cytokines including interleukin-1 receptor antagonist (IL-1ra), interleukin-6 (IL-6), and interleukin-10 (IL-10), which varies Currently there are no available data identifying the inflammatoryresponse during exercise in pancreatic-cancer patients. In healthy

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Exercise as Medicine in the Management of Pancreatic Cancer

Cited by 29 publications

References 38 publications

Exercise Improves Patient Outcomes in Advanced Pancreatic Cancer Patient During Medical Treatment

Exercise Improves Patient Outcomes in Advanced Pancreatic Cancer Patient During Medical Treatment

Clinical decision support system as a risk assessment tool to aid in earlier diagnosis of pancreatic cancer

Inflammatory Response to Exercise in a Pancreatic-cancer Patient: a Case Report

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