Exercise augments the modulatory effects of vitamin E on pre-diabetes-induced aortopathy: a potential role of adiponectin

Dallak, Mohammad; Karib, Abbas O. El; Ellatif, Mohamed Abd; Eid, Refaat A.; Al-Ani, Rihab; Mahmoud, Hesham; Haidara, Mohamed A

doi:10.1080/13813455.2018.1538250

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…Herein, I demonstrated that the levels of CK-MB, LDH, cTnl, and Mb were all increased in DM rats but were repressed after aerobic exercise, which was consistent with the previously described (Sharma et al 2019). It is noticed that both inflammatory cytokines and anti-inflammation factors are deeply involved in not only the progression of DM but also cardiovascular complication (Sharma et al 2019;Dallak et al 2020;Xie et al 2020). Similarly, HE staining assay indicated that inflammatory cells were remarkably infiltrated into myocardial tissues of DM rats underwent MI/RI surgery.…”

Section: Discussionsupporting

confidence: 89%

Aerobic exercise ameliorates myocardial ischemia/reperfusion injury and thrombosis of diabetic rats via activation of AMPK/Sirt1/PGC-1α pathway

Wang¹

2022

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This current work is aimed to make investigations for the action mechanism of aerobic exercise in rats with type 2 diabetes mellitus (T2DM) after myocardial ischemia/reperfusion injury (MI/RI). The high-fat diet was used to induce T2DM in male Wistar rats. After treatments, the rats in the exercise groups were underwent swimming training for 8 weeks. Two days later, all the rats were subjected to perform MI/RI experiments via left anterior descending artery ligation and reperfusion. The blood samples and myocardial tissues were collected for biochemistry analysis and histology assessment. The results demonstrated that aerobic exercise reduced the levels of serum glucose, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and thrombosis in T2DM rats. In addition, aerobic exercise further decreased the levels of myocardial injury markers and also repressed inflammation responses. Furthermore, the AMP-activated protein kinase (AMPK)/silent information regulator factor 2-related enzyme 1 (Sirt1)/peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) pathway could be activated by aerobic exercise. In a word, aerobic exercise may attenuate myocardial ischemia/reperfusion injury and repress thrombosis via activation of the AMPK/Sirt1/ PGC-1α pathway in DM rats.

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Section: Discussionsupporting

confidence: 89%

Aerobic exercise ameliorates myocardial ischemia/reperfusion injury and thrombosis of diabetic rats via activation of AMPK/Sirt1/PGC-1α pathway

Wang¹

2022

gpb

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“…Transmission electron microscopy (TEM). As we previously reported (Dallak et al, 2018), small pieces of 1 mm 3 of kidney tissue was removed and immediately fixed in 2.5 % glutaraldehyde for 6 hours and washed with phosphate buffer (0.1 M, PH 7.4). Post-fixation was made in 1 % osmium tetroxide buffered to PH 7.4 with 0.1 M phosphate buffer at 4 °C for 1-2 hours.…”

Section: Methodsmentioning

confidence: 99%

Acetaminophen Induces Alterations to the Renal Tubular Ultrastructure in a Rat Model of Acute Nephrotoxicity Protected by Resveratrol and Quercetin

et al. 2020

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HAIDARA, M. A.; AL-ANI, B.; EID, R. A.; MOHAMMED, M. E. D.; AL-HASHEM, F. & DALLAK, M. Acetaminophen induces alterations to the renal tubular ultrastructure in a rat model of acute nephrotoxicity protected by resveratrol and quercetin. Int. J. Morphol., 38(3):585-591, 2020.SUMMARY: Acetaminophen (also called paracetamol, or APAP) induced nephrotoxicity is reported after accidental or intentional ingestion of an overdose of the drug. Renal tubular ultrastructural alterations induced by APAP overdose associated with the induction of biomarkers of kidney injury have not been investigated before. Also, we investigated whether the combined polyphenolic anti-inflammatory and antioxidants agents, resveratrol (RES) and quercetin (QUR) can protect against APAP-induced acute kidney injury. The model group of rats received a single dose of APAP (2 g/kg), whereas the protective group of rats was pre-treated for 7 days with combined doses of RES (30 mg/kg) and QUR (50 mg/kg) before being given a single dose of APAP. All rats were then sacrificed one day post APAP ingestion. Harvested kidney tissues were prepared for transmission electron microscopy (TEM) staining and blood samples were assayed for urea, creatinine, and biomarkers of inflammation and oxidative stress. TEM images and blood chemistry analysis showed that APAP overdose induced kidney damage as demonstrated by substantial alterations to the proximal convoluted tubule ultrastructure, and a significant (p<0.05) increase in urea, creatinine, tumor necrosis factor-alpha (TNF-a), and malondialdehyde (MDA) blood levels, which were protected by RES+QUR. These findings indicate that APAP induces alterations to the renal tubular ultrastructure, which is inhibited by resveratrol plus quercetin, which also decreases blood levels of kidney injury biomarkers. HAIDARA, M. A.; AL-ANI, B.; EID, R. A.; MOHAMMED, M. E. D.; AL-HASHEM, F. & DALLAK, M. Acetaminophen induces alterations to the renal tubular ultrastructure in a rat model of acute nephrotoxicity protected by resveratrol and quercetin. Int. J. Morphol., 38(3):585-591, 2020.

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“…As we previously reported (Dallak et al, 2018), small pieces of aortic tissue were removed and immediately fixed in 2.5% glutaraldehyde for 24 hours and washed with phosphate buffer (0.1 M, PH 7.4). Post-fixation was made in 1% osmium tetroxide buffered to PH 7.4 with 0.1 M phosphate buffer at 4 o C for 1-2 hours.…”

Section: Transmission Electron Microscopy (Tem)mentioning

confidence: 99%

Insulin protects against type 1 diabetes mellitus-induced aortopathy associated with the inhibition of biomarkers of vascular injury in rats

Bin-Jaliah

Hewett

Al‐Hashem

et al. 2019

Archives of Physiology and Biochemistry

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Exercise augments the modulatory effects of vitamin E on pre-diabetes-induced aortopathy: a potential role of adiponectin

Cited by 7 publications

References 31 publications

Aerobic exercise ameliorates myocardial ischemia/reperfusion injury and thrombosis of diabetic rats via activation of AMPK/Sirt1/PGC-1α pathway

Aerobic exercise ameliorates myocardial ischemia/reperfusion injury and thrombosis of diabetic rats via activation of AMPK/Sirt1/PGC-1α pathway

Acetaminophen Induces Alterations to the Renal Tubular Ultrastructure in a Rat Model of Acute Nephrotoxicity Protected by Resveratrol and Quercetin

Insulin protects against type 1 diabetes mellitus-induced aortopathy associated with the inhibition of biomarkers of vascular injury in rats

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