Exercise Capacity Correlates With Left Atrial Structural Remodeling as Detected by Late Gadolinium-Enhanced Cardiac Magnetic Resonance in Patients With Atrial Fibrillation

Rizvi, Kamran; Burgon, Nathan; King, Jordan B.; Akoum, Nazem; Vergara, Gaston; Anderson, Paul A.; Gardner, Gregory; McGann, Christopher; Wilson, Brent D.; Kholmovski, Eugene; MacLeod, Robert S.; Chelu, Mihail G.; Marrouche, Nassir F.

doi:10.1016/j.jacep.2016.03.012

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…Greater exercise capacity and low inflammatory status are known to decrease atrial fibrillation burden after catheter ablation. 27 In addition, long-term aggressive management of cardiac risk factors reduced atrial fibrillation recurrence in paroxysmal and persistent atrial fibrillation patients after catheter ablation. 28 The European Society of Cardiology guideline recommends daily moderate physical activity for atrial fibrillation prevention.…”

Section: Discussionmentioning

confidence: 99%

Exercise-based cardiac rehabilitation for patients with catheter ablation for persistent atrial fibrillation: A randomized controlled clinical trial

Kato

Ogano

Mori

et al. 2019

Eur J Prev Cardiolog

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Aims The efficacy and safety of cardiac rehabilitation for patients with persistent atrial fibrillation who restored sinus rhythm after catheter ablation remains unclear. The aim of the present study was to evaluate the effects of cardiac rehabilitation on exercise capacity, inflammatory status, cardiac function, and safety in patients with persistent atrial fibrillation who had catheter ablation. Methods In this randomized controlled study, 61 patients treated with catheter ablation for persistent atrial fibrillation (male, 80%; mean age, 66 ± 9 years) were analyzed. Thirty patients underwent cardiac rehabilitation (rehabilitation group), whereas the remaining 31 patients received usual care (usual care group). The rehabilitation group underwent endurance and resistance training with moderate intensity, at least three times per week for six months. Six-minute walk distance, muscle strength, serum high-sensitivity C-reactive protein, plasma pentraxin 3, left ventricular ejection fraction and atrial fibrillation recurrence were assessed at baseline and at six-month follow-up. Results In the rehabilitation group, significant increases in the six-minute walk distance, handgrip strength, leg strength and left ventricular ejection fraction and significant decreases in high-sensitivity C-reactive protein and plasma pentraxin 3 concentrations were observed at six-month follow-up compared with baseline (all p < 0.05). No significant changes were observed in the usual care group. During the six-month follow-up period, the number of patients with atrial fibrillation recurrence was six (21.4%) in the rehabilitation group and eight (25.8%) in the usual care group (risk ratio, 0.83; 95% confidence interval, 0.33 to 2.10). Conclusions Cardiac rehabilitation improved exercise capacity without increasing the risk for atrial fibrillation recurrence. It may also be effective in managing systemic inflammatory status and systolic left ventricular function in patients with persistent atrial fibrillation treated with catheter ablation.

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Section: Discussionmentioning

confidence: 99%

Exercise-based cardiac rehabilitation for patients with catheter ablation for persistent atrial fibrillation: A randomized controlled clinical trial

Kato

Ogano

Mori

et al. 2019

Eur J Prev Cardiolog

View full text Add to dashboard Cite

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Atrial Fibrillation Status and Physical Rehabilitation in Older Patients With Acute Decompensated Heart Failure: An Analysis From the REHAB‐HF Trial

Corsi,

Dikdan,

Upadhyay

et al. 2024

JAHA

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Background The REHAB‐HF (Rehabilitation Therapy in Older Acute Heart Failure Patients) trial demonstrated that a transitional, tailored, progressive rehabilitation intervention improved physical function, 6‐minute walk distance, frailty, quality‐of‐life, and depression in older patients hospitalized for acute decompensated heart failure. This analysis assessed the impact of atrial fibrillation (AF) on intervention benefits. Methods and Results Of 349 enrolled patients hospitalized for acute decompensated heart failure (mean age 72.7±8.1 years), 176 (50.4%) had AF. Participants were randomly assigned to 12‐week rehabilitation intervention or attention control. The primary outcome was Short Physical Performance Battery score at 3 months. Participants with AF were older (74.4±8.3 versus 70.8±7.5, P <0.0001) and had higher prevalence of heart failure with preserved ejection fraction (58.5% versus 47.4%, P =0.037). Patients with and without AF had similar improvement in Short Physical Performance Battery score (mean difference between rehabilitation intervention and attention control, 1.5 [95% CI, 0.6–2.3] versus 1.5 [95% CI, 0.7–2.3]; P <0.001). Those with AF had significant improvement in 6‐minute walk distance (all P <0.05) and each of the Short Physical Performance Battery domains: balance, 4‐meter walk, and chair rise. Kansas City Cardiomyopathy Questionnaire score significantly improved in patients with AF ( P <0.05) but not those without AF ( P >0.05). Interaction P values for 3‐month outcomes by AF status were not significant ( P >0.1). No significant differences were observed in deaths, all‐cause rehospitalizations, or heart failure hospitalizations at 6 months. Conclusions In older, hospitalized patients with acute decompensated heart failure, the presence of AF did not significantly affect the benefit of the rehabilitation intervention on physical function and quality of life. The intervention appears safe and effective regardless of AF status. Registration URL: https://www.clinicaltrials.gov ; Unique Identifier: NCT02196038.

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Exercise Capacity Correlates With Left Atrial Structural Remodeling as Detected by Late Gadolinium-Enhanced Cardiac Magnetic Resonance in Patients With Atrial Fibrillation

Abstract: EC is inversely associated with LA-TR in patients with AF and is predictive of freedom from AF post-ablation.

Cited by 2 publications

References 24 publications

Exercise-based cardiac rehabilitation for patients with catheter ablation for persistent atrial fibrillation: A randomized controlled clinical trial

Exercise-based cardiac rehabilitation for patients with catheter ablation for persistent atrial fibrillation: A randomized controlled clinical trial

Atrial Fibrillation Status and Physical Rehabilitation in Older Patients With Acute Decompensated Heart Failure: An Analysis From the REHAB‐HF Trial

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