Exercise compliance among patients with multiple myeloma undergoing chemotherapy: a retrospective study

Shallwani, Shirin M.; Dalzell, Mary-Ann; Sateren, Warren B.; O’Brien, Suzanne

doi:10.1007/s00520-015-2680-2

Cited by 21 publications

(40 citation statements)

References 36 publications

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“…Physical exercise is considered an essential factor for improving cancer survival. Previous studies have indicated that exercise interventions are efficacious in men with prostate cancer (41,42) and in multiple myeloma (43,44). In endometrial, ovarian and colorectal cancer survivors, lifestyle interventions that include regular participation in physical activity are associated with positive health outcomes (45,46).…”

Section: Discussionmentioning

confidence: 99%

Physical exercise modulates the level of serum MMP-2 and MMP-9 in patients with breast cancer

et al. 2016

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Abstract. Matrix metalloproteinases (MMPs) exhibit an important function in extracellular matrix degradation. MMPs modulate the activation of growth factors, cytokines and metastasis. At present, the effect of exercise on serum levels of MMP-2 and -9 remains unclear. The aim of the present study was to investigate the effect of various physical activities on the circulating levels of MMP-2 and -9 in breast cancer (BC) survivors and healthy subjects. A total of 66 female subjects were enrolled in the present study. The cohort included 46 BC survivors and 20 healthy subjects divided into 5 groups: Group A (17 BC survivors, participating in recreational dragon boat paddling), group B (14 BC survivors, participating in recreational physical activity), group C (15 sedentary BC survivors), group D (10 healthy subjects, participating in recreational physical activity) and group E (10 sedentary healthy subjects). ELISA assays revealed a significant increase in the level of circulating MMP-2 in group B compared with all other groups. Recreational physical activity increased the levels of MMP-9 in healthy subjects (group D vs. E), however, the differences were not statistically significant, while in the BC survivor groups the results were opposite, with exercise reducing MMP-9 levels (group B vs. C). Furthermore, a significant increase in MMP-2 was observed in group B lymph node metastasis-positive (N+) subjects compared with group A and C N+ subjects. Thus, the results of the present study indicate that various physical activities modulate the levels of circulating MMP-2 and -9 in BC survivors, and the same exercise program induces a different effect when undertaken by healthy subjects and BC survivors. These results may have important implications with regard to the selection of appropriate physical activities for BC survivors, leading to improvements to their survival and prevention of recurrence, as well as amelioration of physical function, quality of life and fatigue.

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Section: Discussionmentioning

confidence: 99%

Physical exercise modulates the level of serum MMP-2 and MMP-9 in patients with breast cancer

et al. 2016

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“…Commonly reported barriers to physical activity are pain, fear of fracture risk, lack of confidence and fatigue (Groeneveldt et al, 2013). Although more high quality randomised control trials (RCTs) are required in myeloma patients to determine efficacy (Gan et al, 2016;Smith et al, 2015), exercise training has been shown to be safe and feasible (Groeneveldt et al, 2013), with high attendance and adherence (Groeneveld et al, 2013;Shallwani et al, 2015) and higher physical activity levels have been associated with better quality of life both during and off active treatment (Jones et al, 2004;Groeneveld et al, 2013). Rehabilitation in myeloma patients after HSCT improves physical performance, muscle strength, aerobic capacity and immunological function; reduces fatigue and improves psychological outcomes (Groeneveldt et al, 2013;Persoon et al, 2013).…”

Section: Physical Fitness and Functionalitymentioning

confidence: 99%

Guidelines for screening and management of late and long‐term consequences of myeloma and its treatment

et al. 2017

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SummaryA growing population of long-term survivors of myeloma is now accumulating the 'late effects' not only of myeloma itself, but also of several lines of treatment given throughout the course of the disease. It is thus important to recognise the cumulative burden of the disease and treatment-related toxicity in both the stable and active phases of myeloma, some of which is unlikely to be detected by routine monitoring. We summarise here the evidence for the key late effects in long-term survivors of myeloma, including physical and psychosocial consequences (in Parts 1 and 2 respectively), and recommend the use of late-effects screening protocols in detection and intervention. The early recognition of late effects and effective management strategies should lead to an improvement in the management of myeloma patients, although evidence in this area is currently limited and further research is warranted.Keywords: myeloma, late effects, quality of life, haematopoietic stem cell transplantation, chemotherapy. MethodologyThese guidelines were developed using the following stages:• Review of key literature from 1 April 2006 to 31 March 2016 using the Cochrane database (search term: myeloma) and Medline: search terms used were [myeloma] + late effects, long term effects, frailty, geriatric assessment, infection, infection prophylaxis, vaccination, nutrition, exercise, rehabilitation, employment, endocrine, disability, late treatment consequences, cancer survivorship (for all papers); and psychological, fatigue, second primary malignancy, quality of life, infection (reviews). As organ-specific areas, such as renal and bone, have been covered in previous guidelines, searches were not re-performed.• Development of key recommendations based on randomised, controlled trial evidence. In the absence of randomised data, recommendations were developed on the basis of literature review and a consensus of expert opinion.• Updating of the levels of evidence and grades of recommendation using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) nomenclature for assessing the quality of evidence and providing strength of recommendations (Appendix; http:// www.gradeworkinggroup.org/index.htm).• Review of the manuscript was performed by the British Society for Haematology (BSH) Guidelines Committee and Haemato-Oncology Task Force, and the BSH sounding board, comprised of 50 or more members of the BSH who have reviewed this Guidance and commented on its content and applicability in the UK setting, consistent with the primary target audience of UK-based multidisciplinary clinical teams treating myeloma and its complications. Involvement of patient perspectives was through Myeloma UK.• In preparing these guidelines, the authors have considered overall cost-effectiveness and budget impact of recommended interventions as well as clinical efficacy data and the burden/impact on patients. Formal health economic assessments have not been carried out.

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“…Within the period of interest for our analysis, 39.4% of patients with bone metastasis exercised at the Wellness Centre and an additional 26% were given home programs. In our previously summarized studies, patients with spinal metastases were successfully treated with low-level cardiovascular and resistance training, improving their quality of life despite advanced cancer 33,34 .…”

Section: Discussionmentioning

confidence: 99%

“…To identify factors that contribute to compliance versus noncompliance with our model of exercise prescription, we retrospectively conducted, in 2014, a review of 41 patients with multiple myeloma 34 . Despite the fact that 81% of the patients had bone lesions and were undergoing active treatment, overall compliance with exercise prescription was 71%, mean levels of physical activity increased significantly (p < 0.001), and fatigue severity was reduced (p = 0.003).…”

Section: Select Population Outcomesmentioning

confidence: 99%

Rehabilitation and Exercise Oncology Program: Translating Research into a Model of Care

et al. 2017

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Exercise compliance among patients with multiple myeloma undergoing chemotherapy: a retrospective study

Cited by 21 publications

References 36 publications

Physical exercise modulates the level of serum MMP-2 and MMP-9 in patients with breast cancer

Physical exercise modulates the level of serum MMP-2 and MMP-9 in patients with breast cancer

Guidelines for screening and management of late and long‐term consequences of myeloma and its treatment

Rehabilitation and Exercise Oncology Program: Translating Research into a Model of Care

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