Exercise dose on hepatic fat and cardiovascular health in adolescents with excess of adiposity

González-Ruíz, Katherine; Correa-Bautista, Jorge Enrique; Izquierdo, Mikel; García-Hermoso, António; Martínez‐Vizcaíno, Vicente; Lobelo, Felipe; González‐Jiménez, Emilio; Correa‐Rodríguez, María; Fernández‐Irigoyen, Joaquín; Palomino‐Echeverría, Sara; Santamaría, Enrique; Ramírez‐Vélez, Robinson

doi:10.1111/ijpo.12869

Cited by 10 publications

(9 citation statements)

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“…The mean age of the participants was 13.5 (1.6) years, the mean BMI z -score was 1.8 (0.5), and the mean body fat was 39.9 (4.6)%. The information regarding the hepatic fat content (primary endpoint), secondary outcomes such as traditional cardiovascular health markers (body composition, serum lipids, aminotransferases and health-related physical fitness components), and diet intake were described in a previous publication ( 16 ).…”

Section: Resultsmentioning

confidence: 99%

“…Description and characteristics of the study were given to parents or legal guardians, and a written informed consent was provided from both guardian and adolescent. Full details of the original trial protocol are published ( 15 , 16 ), and participants were recruited from a single official school (in Spanish, Colegio Instituto Técnico Internacional) from Bogotá, Colombia.…”

Section: Methodsmentioning

confidence: 99%

“…Routine school physical education classes were not an exclusion criterion. Details about randomization and allocation procedures and sample size considerations have been published elsewhere ( 16 ).…”

Section: Methodsmentioning

confidence: 99%

“…Risks was minimized by identifying contraindications to the testing and training protocols via a health history and a thorough physician examination before the testing sessions. Details about interventions have been described ( 16 ). In terms of training intensity, the actual values were the mean heart rates measured in the high-intensity physical education class (HIPE), low-to-moderate intensity physical education class (LIPE), or a combined group (PLUS) groups in a subsample (25 participants).…”

Section: Methodsmentioning

confidence: 99%

“…Compliance to the exercise protocol, an essential element of an efficacy study, was defined as successfully completing > 70% of scheduled exercise sessions, maintaining the target exercise heart rate ± 4 beats/min -1 for the prescribed duration of the playground games session. Details of the exercise programs have been published elsewhere ( 16 ). All study participants received a hygiene–dietary management plan that included educational and nutritional support throughout the study.…”

Section: Methodsmentioning

confidence: 99%

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Effects of Different Doses of Exercise on Inflammation Markers Among Adolescents With Overweight/Obesity: HEPAFIT Study

Ramírez‐Vélez

García-Hermoso

Correa‐Rodríguez

et al. 2022

The Journal of Clinical Endocrinology &Amp; Metabolism

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Propose Obesity-related metabolic risk factors in adolescents with overweight/obesity may be associated with systemic low-grade inflammation, and therefore we investigated whether a 6-month exercise training altered markers of inflammation. Methods Secondary analyses of a randomized controlled exercise-based intervention trial (September 2017 to December 2018). Adolescents aged 11 to 17 years (Tanner stage II to V), 70% girls, with a body mass index (BMI) z-score at or above the 85 th percentile, and/or with excess of adiposity (body fat >30%). The participants were randomly assigned to the following 4 groups for 6 months: (1) standard physical education lessons, as a control (CTRL); (2) high-intensity physical education class (HIPE); (3) low-to-moderate intensity physical education class (LIPE); (4) a combined group (PLUS group). Inflammatory markers and immune molecules including chemokines, cytokines, and growth factors (n=65 biomarkers) were determined by cytokine antibody array. Results Of the 120 randomly assigned participants, 95 were included in the analysis. Considering these 22 proteins, the LIPE group shows statistical significance in 9 proteins with logfold-change (logFC) and p<0.05 was found in BLC, Eotaxin, FGF-6, GCP-2, I-309, IGFBP-4, MCP-4, NAP-2, and PARC), followed by the PLUS group in 9 proteins (BLC, EGF, Eotaxin, FGF-6, MCP-4, NAP-2, Osteopontin, PARC, and RANTES), the HIPE group in 7-proteins (FGF-4, FGF-7, GCP-2, IGF-1, IGFBP-1, IGFBP-4, and MIP-1 delta), the CTRL group in 6 proteins (FGF-4, IP-10, Leptin, MCP-1, MIG, and MIP-1 delta). However, sub-analysis performed to detect differentially expressed proteins at baseline and post-intervention, with significance at an adjusted p value ≤ 0.05 and absolute (logFC) ≥ 1.0, shown three down-regulated proteins in the LIPE group (BLC (logFC)= 1.27, Eotaxin (logFC)= 1.18 and MCP-4 (logFC)= 1.14), and four proteins in the HIPE group (BLC (logFC)= 1.45, FGF-6 (logFC)= 1.20, MCP-4 (logFC)= 1.50, and PARC (logFC)= 1.33), supporting that the changes that we observed in the exercise groups were not time-related changes but occurred in response to exercise. Conclusions Implementing a 6-month physical exercise program in overweight/obese adolescents, based on LIPE and PLUS groups, significantly change several circulating inflammatory levels. Interventions involving supervised physical exercise may reduce the associated effects of systemic low-grade inflammation, thus preventing the development of obesity-related metabolic diseases in adolescents with overweight/obesity.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Effects of Different Doses of Exercise on Inflammation Markers Among Adolescents With Overweight/Obesity: HEPAFIT Study

Ramírez‐Vélez

García-Hermoso

Correa‐Rodríguez

et al. 2022

The Journal of Clinical Endocrinology &Amp; Metabolism

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Exercise and Insulin Resistance Markers in Children and Adolescents With Excess Weight

García-Hermoso,

López-Gil,

Izquierdo

et al. 2023

JAMA Pediatr

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ImportanceAlthough benefits have been reported for most exercise modalities, the most effective exercise approaches for reducing insulin resistance in children and adolescents with excess weight and the optimal exercise dose remain unknown.ObjectiveTo compare exercise training modalities and their association with changes in insulin resistance markers among children and adolescents with excess weight and to establish the optimal exercise dose.Data SourcesFor this systematic review and network meta-analysis, 6 electronic databases (PubMed, EMBASE, Cochrane Central Register of Controlled Trials, Scopus, Web of Science, and CINAHL) were searched for studies from inception to April 1, 2023.Study SelectionRandomized clinical trials (ie, randomized controlled trials and randomized trials without a control group) were included if they reported outcomes associated with aerobic training, resistance training, high-intensity interval training (HIIT), or a combination of these interventions.Data Extraction and SynthesisData extraction for this systematic review was conducted following a network meta-analysis extension of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guideline. Effect sizes were calculated as the mean difference (MD) with 95% CI using random-effects inverse-variance models with the Hartung-Knapp-Sidik-Jonkman method. The hierarchy of competing interventions was defined using the surface under the cumulative ranking curve. The Cochrane Risk-of-Bias tool, version 2 (RoB2), was used to independently assess the risk of bias of the included studies. The certainty of evidence in consistent networks was assessed using the Grading of Recommendation, Assessment, Development and Evaluation approach. The study protocol was prospectively registered with PROSPERO. Data analyses were conducted between May and June 2023.Main Outcomes and MeasuresThe primary outcomes were fasting glucose, insulin, and homeostatic model assessment for insulin resistance (HOMA-IR).ResultsThis analysis included 55 studies with a total of 3051 children and adolescents (mean [SD] age, 13.5 [2.3] years; 1537 girls [50.4%] and 1514 boys [49.6%]). Exercise was associated with reductions in fasting insulin (MD, −4.38 μU/mL [95% CI, −5.94 to −2.82 μU/mL]) and HOMA-IR (MD, –0.87 [95% CI, –1.20 to –0.53]). A nonlinear association in both markers was observed, with a required minimal exercise dosage of approximately 900 to 1200 metabolic equivalent of task minutes per week, especially in children and adolescents with insulin resistance at baseline. Combination HIIT and resistance training and concurrent training were the most effective approaches for reducing insulin resistance markers. On average, the certainty of evidence varied from low to moderate.Conclusions and RelevanceThese findings underscore the role of exercise interventions in enhancing insulin resistance markers among children and adolescents with overweight and obesity. It is advisable to include resistance exercises alongside aerobic and HIIT programs for a minimum of two to three 60-minute sessions per week.

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Association between alanine aminotransferase as surrogate of fatty liver disease and physical activity and sedentary time in adolescents with obesity

et al. 2022

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Exercise dose on hepatic fat and cardiovascular health in adolescents with excess of adiposity

Cited by 10 publications

References 38 publications

Effects of Different Doses of Exercise on Inflammation Markers Among Adolescents With Overweight/Obesity: HEPAFIT Study

Effects of Different Doses of Exercise on Inflammation Markers Among Adolescents With Overweight/Obesity: HEPAFIT Study

Exercise and Insulin Resistance Markers in Children and Adolescents With Excess Weight

Association between alanine aminotransferase as surrogate of fatty liver disease and physical activity and sedentary time in adolescents with obesity

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