Exercise Effect on Oxidative Stress Is Independent of Change in Estrogen Metabolism

Abstract

Purpose: The effect of exercise training on lipid peroxidation and endogenous estrogens is not well understood in premenopausal women. Exercise effects on these variables could mediate observed associations of exercise with hormonally related cancers, including breast cancer. The purpose of the study is to determine the effect of 15 weeks of aerobic exercise on lipid peroxidation, endogenous estrogens, and body composition in young, healthy eumenorrheic women. Methods: Fifteen sedentary premenopausal women (18-25 years) participated. Pre-and post-exercise training urine collection (three 24-h samples) started 48 h after most recent exercise session for analysis of a marker of lipid peroxidation (F 2 -isoprostane) and endogenous estrogens, including 2-hydroxyestrogens, 4-hydroxyestrogens, 16-A-hydroxyestrone, and ratios of these metabolites (2:16, 2:4). Body composition was measured by dual-energy X-ray absorptiometry, and F 2 -isoprostanes and estrogens were measured by gas chromatography-mass spectrometry. Results: Aerobic exercise resulted in a 34% decrease in F 2 -isoprostane (P = 0.02), a 10% increase in fitness (P = 0.004), a 1.2 kg decrease in body mass (P = 0.007), and a 1.8 kg decrease in fat mass (P = 0.04). No significant changes were noted in estrogens.

Moderate exercise training has anorexogenic effect associated with improved oxidative stress in obese women

“…Consistent with a previous report (Schmitz et al, 2008), the present study found that the free F2-Isoprostanes in plasma were significantly lower following 8 weeks of exercise in obese and leptin responder normal-weight participants. However, some studies found decreased F2-Isoprostanes levels but only after acute excessive exercise (Nasca et al, 2010).…”

Raisins and walking alter appetite hormones and plasma lipids by modifications in lipoprotein metabolism and up-regulation of the low-density lipoprotein receptor

“…However, the increase in ghrelin resulting from wheat fiber consumption was not associated with satiety [65]. The rise in plasma ghrelin for RAISIN and RAISIN + WALK were not expected given the increase in plasma leptin, as an inverse relationship between these variables usually exists [66]. However, it is possible that the elevation in circulating leptin decreased appetite for the subjects who consumed raisins, causing a reduction in food intake.…”

Physiologische und molekulare Mechanismen der Wirkung von körperlicher Aktivität auf das Krebsrisiko und den Verlauf einer Krebserkrankung

“…Vergleichbare Resultate werden auch aus mehreren nicht-kontrollierten Interventionsstudien berichtet, bei denen um 25 bis 34% erniedrigte F2-Isoprostankonzentrationen nach einem körperlichen Training über zwölf bis 15 Wochen gemessen wurden [53,54]. In einer randomisierten achtwöchigen Studie bei älte-ren Patienten mit Typ-2-Diabetes wurden hingegen keine signifikanten Effekte beobachtet [55].…”