Exercise Effects on Adipose Tissue Postprandial Lipolysis and Blood Flow in Children

Yan, Huimin; Pierce, Joseph R.; Myers, Kimberly; DuBose, Katrina D.; Dubis, Gabriel S.; Tanner, Charles J.; Hickner, Robert C.

doi:10.1249/mss.0000000000001566

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…67 Clinical studies have shown that in adults with obesity, insulin poorly inhibits lipolysis, which may indicate that the hypertrophy of adipose tissue is resistant to insulin anti-lipolysis. 68 Clinically, it showed less insulin sensitivity in young adults with obesity accompanied by impaired glucose tolerance, including insufficient insulin action inhibiting lipolysis and lipid oxidation, as well as βcell dysfunction in lipid and glucose metabolism. 69 Wueest 70 showed that adipose tissue lipolysis mediated by glycoprotein 130 (gp130) promotes liver steatosis and insulin resistance.…”

Section: Anti-lipolysis Induced By Insulin In Adipose Hypertrophymentioning

confidence: 99%

<p>Anti-Lipolysis Induced by Insulin in Diverse Pathophysiologic Conditions of Adipose Tissue</p>

Zhao¹,

Wu²,

Rong³

et al. 2020

DMSO

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As an important energy reservoir, adipose tissue maintains lipid balance and regulates energy metabolism. When the body requires energy, adipocytes provide fatty acids to peripheral tissues through lipolysis. Insulin plays an important role in regulating normal fatty acid levels by inhibiting lipolysis. When the morphology of adipose tissue is abnormal, its microenvironment changes and the lipid metabolic balance is disrupted, which seriously impairs insulin sensitivity. As the most sensitive organ to respond to insulin, lipolysis levels in adipose tissue are affected by impaired insulin function, which results in serious metabolic diseases. However, the specific underlying mechanisms of this process have not yet been fully elucidated, and further study is required. The purpose of this review is to discuss the effects of adipose tissue on the anti-lipolysis process triggered by insulin under different conditions. In particular, the functional changes of this process respond to inconsonantly morphological changes of adipose tissue.

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Section: Anti-lipolysis Induced By Insulin In Adipose Hypertrophymentioning

confidence: 99%

<p>Anti-Lipolysis Induced by Insulin in Diverse Pathophysiologic Conditions of Adipose Tissue</p>

Zhao¹,

Wu²,

Rong³

et al. 2020

DMSO

View full text Add to dashboard Cite

show abstract

“…Biologically, arguments explaining why activity intensity may be relevant to obesity are speculative, including appetite regulation and insulin sensitivity improvement [ 27 ]. Evidence from an intervention study suggests that high-intensity physical activity as aerobic exercise can increase subcutaneous adipose nutritive blood flow and reduce suppression of lipolysis [ 28 ]. There is increasing emphasis that VPA can incite improvements in body composition and obesity.…”

Section: Discussionmentioning

confidence: 99%

Association of Reallocating Time in Different Intensities of Physical Activity with Weight Status Changes among Normal-Weight Chinese Children: A National Prospective Study

Tan

Cai

Lai

et al. 2020

IJERPH

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Background: Time spent in different intensity-specific physical activities is codependent, but the substitution effect of different activities on weight status changes in children remains unclear. This study aims to investigate the prospective association between reallocating time in different intensities of physical activity and weight status changes among Chinese children. Methods: A national sample of 15,100 normal-weight children aged 7–18 years (46.7% boys) were recruited in September 2013 and followed up for nine months. Vigorous-intensity physical activity (VPA), moderate-intensity physical activity (MPA), walking, and sedentary time were obtained by International Physical Activity Questionnaire Short Form (IPAQ-SF). Height and weight were objectively measured, by which body mass index (BMI) and BMI z-score were calculated. Weight status was classified by the Chinese criteria for 7- to 18-year-old children. Isotemporal substitution analyses (including single-factor model, partition model, and isotemporal substitution model) were applied to examine the association of time allocation with weight status changes. Results: Each 30 min/day of increase in VPA was favorably associated with a 13.2% reduced risk of incident overweight/obesity in a single-factor model and a 15.6% reduced risk in a partition model. Negative associations were found between VPA, MPA, walking and the risk of being underweight in the single-factor model, but not in the partition model. In substitution models, replacing 30 min/day sedentary time with an equal amount of VPA was favorably associated with a 16.1% reduction of the risk of being overweight/obese. Conclusion: These findings highlight the need for promoting vigorous-intensity physical activity in children.

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Exercise-regulated lipolysis: Its role and mechanism in health and diseases

Zhu,

Guo

2024

Journal of Advanced Research

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Exercise Effects on Adipose Tissue Postprandial Lipolysis and Blood Flow in Children

Abstract: Daily bouts of acute aerobic exercise should be used to improve the antilipolytic and nutritive blood flow response to a subsequent meal in obese children.

Cited by 4 publications

References 37 publications

<p>Anti-Lipolysis Induced by Insulin in Diverse Pathophysiologic Conditions of Adipose Tissue</p>

<p>Anti-Lipolysis Induced by Insulin in Diverse Pathophysiologic Conditions of Adipose Tissue</p>

Association of Reallocating Time in Different Intensities of Physical Activity with Weight Status Changes among Normal-Weight Chinese Children: A National Prospective Study

Exercise-regulated lipolysis: Its role and mechanism in health and diseases

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