2002
DOI: 10.1016/s0197-4580(02)00028-3
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Exercise, experience and the aging brain1

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Cited by 448 publications
(317 citation statements)
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References 159 publications
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“…On the other hand, epidemiological studies indicate that exercise can decrease cognitive decay associated to aging (Kramer et al, 1999) and is inherently beneficial for reducing the risk of various diseases (Friedland et al, 2001;Laurin et al, 2001). Experimental studies show that exercise can improve cognitive function in both young and aged animals (Radak et al, 2001;Churchill et al, 2002). Although the potential of exercise to protect against neurological damage is well recognized, the capacity of exercise to interact with specific molecular systems impacted by insult has not been experimentally scrutinized.…”
mentioning
confidence: 99%
“…On the other hand, epidemiological studies indicate that exercise can decrease cognitive decay associated to aging (Kramer et al, 1999) and is inherently beneficial for reducing the risk of various diseases (Friedland et al, 2001;Laurin et al, 2001). Experimental studies show that exercise can improve cognitive function in both young and aged animals (Radak et al, 2001;Churchill et al, 2002). Although the potential of exercise to protect against neurological damage is well recognized, the capacity of exercise to interact with specific molecular systems impacted by insult has not been experimentally scrutinized.…”
mentioning
confidence: 99%
“…Studies involving humans and animals have indicated that engaging in thirty minutes of exercise for a minimum of three times a week will result in increased blood flood and brain mass, improved circulation and cognition, as well as a heightened mood (Adlard, Perreau, Engesser-Cesar, & Cotman, 2003;Churchill et al, 2002;Markakis & Gage, 1999;Sutoo & Akiyama, 2003;Tomporowski, 2003;Van Praag, Kempermann, & Gage, 1999). Cotman's (2015) work with rodents revealed that exercise both "increases the numbers of synapses, counteracting the synaptic loss that occurs with age," as well as "stimulates the brain to generate more neurons" (p. 1).…”
Section: Developmental Benefits Of Movementmentioning
confidence: 99%
“…Neurotransmitters en neurotrofines, stoffen die belangrijk zijn voor de plasticiteit van de hersenen (Hennigan, O'Callaghan & Kelly, 2007), worden gestimuleerd als gevolg van fysieke activiteit en leiden tot de aanmaak van nieuwe hersencellen (neurogenese) en verbindingen tussen hersencellen (synaptogenese) (Churchill et al, 2002). Zo maken muizen na het rennen in tredmolens nieuwe hersencellen aan in de gyrus dendatus (Van Praag, Kempermann & Gage, 1999).…”
Section: Lichamelijke Activiteit En Cognitieunclassified
“…Fysieke activiteit blijkt niet alleen gunstige effecten te hebben op de lichamelijke conditie, maar ook op het functioneren van de hersenen (Churchill et al, 2002). Uit dierexperimenteel onderzoek blijkt dat verschillende neurobiologische mecha-Lopen als activiteit bij ouderen met dementie om de cognitie te verbeteren Het is echter enigszins verrassend dat er slechts weinig studies zijn geweest die de effecten hebben onderzocht van lopen op cognitie bij ouderen met dementie.…”
Section: Neurobiologische Basisunclassified