Exercise for improving outcomes after osteoporotic vertebral fracture

Gibbs, Jenna C.; MacIntyre, Norma J.; Ponzano, Matteo; Templeton, Jeffrey A.; Thabane, Lehana; Παπαϊωάννου, Αλεξάνδρα; Giangregorio, Lora

doi:10.1002/14651858.cd008618.pub3

Cited by 58 publications

(70 citation statements)

References 76 publications

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“…In addition, exercise can help to achieve beneficial and significant effects on quality of life, balance, and functional mobility also in patients with osteoporosis-related vertebral fractures (43,44). However, there is still no agreement on which type of exercise, in terms of intensity, frequency, duration, type and setting, is optimal and can affect bone metabolism in people with osteoporosis (45)(46)(47).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review

et al. 2020

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Background: Bone imbalance between anabolic and catabolic processes at the level of remodeling unit due to the prevalence of resorbing activity, represents a health problem of aging. The consequence is the negative balance of bone turnover that can lead to osteoporosis. Physical activity (PA) can play a central role in the comprehensive management of osteoporosis, since it induces the anabolism of bone tissue. Bone turnover biomarkers, reflecting the cellular activity linked to bone metabolism, can represent an evaluation tool to assess the efficacy of PA in the osteoporotic population. The aim of this systematic review, conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, was to investigate the effects of PA interventions on bone biomarkers in people with osteoporosis. Methods: A comprehensive literature search of electronic databases was conducted through PubMed, Cochrane, Cinahl, Embase, Trip, to find randomized controlled trials (RCTs) investigating the topic of PA and bone turnover biomarkers in the osteoporosis population. In accordance with the Cochrane risk-of-bias tool, the quality of each study was assessed. Results: Out of 992 identified articles, 136 full texts were screened. Only three RTCs matched the eligibility criteria. In one study, sub-maximal aerobic exercise improved Bone-specific alkaline phosphatase (bone formation biomarker) and Amino-terminal Crosslinked Telopeptide of type 1 collagen (bone resorption biomarker) in osteoporotic women. The other two studies showed a positive effect on total alkaline phosphatase (a non-specific bone formation biomarker) in women with osteoporosis. Conclusion: The systematic review revealed possible exercise benefits in terms of improving bone formation and decreasing bone resorption biomarkers in the osteoporotic population. However, these results should be interpreted with caution, especially due to the limited number and poor quality of the studies included. Further research is needed to estimate the influence of PA on bone biomarkers in the osteoporosis management.

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Section: Discussionmentioning

confidence: 99%

The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review

et al. 2020

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“…However, individuals with vertebral fractures require exercise that is tailored to address safety and related impairments [ 13 ]. A recently updated systematic review on the effect of exercise for people with vertebral fracture [ 14 ] concluded that there is moderate-quality evidence that exercise improves physical performance. However, few studies have evaluated whether the effects of exercise are sustained after the intervention has ceased [ 15 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

Physical fitness in older women with osteoporosis and vertebral fracture after a resistance and balance exercise programme: 3-month post-intervention follow-up of a randomised controlled trial

Stanghelle

Bentzen

Giangregorio

et al. 2020

BMC Musculoskelet Disord

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Background Exercise is recommended for individuals with vertebral fractures, but few studies have investigated the effect of exercise on outcomes of importance for this population. Post-intervention effects of exercise are even less studied. The objective of this study was to evaluate habitual walking speed and other health-related outcomes after cessation of a 3-month exercise intervention. Methods This follow-up study was conducted 3 months post-intervention of a randomised controlled trial. A total of 149 community-dwelling Norwegian women aged 65 years or older, diagnosed with osteoporosis and vertebral fracture were randomised into either exercise or control group. Primary outcome was habitual walking speed at 3 months. Secondary outcomes were other measures of physical fitness – including the Four Square Step Test (FSST), functional reach, grip strength and Senior Fitness Test – measures of health-related quality of life and fear of falling. Herein we report secondary data analysis of all outcomes at 6 months (3 months post-intervention). Data were analysed according to the intention-to-treat principle, linear mixed regression models were employed. Results For the primary outcome, habitual walking speed, there was no statistically significant difference between groups (0.03 m/s, 95%CI − 0.02 to 0.08, p = 0.271) at the 3-month post-intervention follow-up. For secondary outcomes of physical fitness, statistically significant differences in favour of the intervention group were found for balance using the FSST (− 0.68 s, 95%CI − 1.24 to − 0.11, p = 0.019), arm curl (1.3, 95%CI 0.25 to 2.29, p = 0.015), leg strength using the 30-s sit to stand (1.56, 95%CI 0.68 to 2.44, p = 0.001) and mobility using the 2.45-m up and go (− 0.38 s, 95%CI − 0.74 to − 0.02, p = 0.039). There was a statistically significant difference between the groups regarding fear of falling in favour of the intervention group (− 1.7, 95%CI − 2.97 to − 0.38, p = 0.011). No differences between groups were observed for health-related quality of life. Conclusion The results show the improved effects of a multicomponent exercise programme on outcomes like muscle strength, balance and mobility as well as fear of falling in a group of older women with osteoporosis and vertebral fracture 3 months post-intervention. Trial registration ClinicalTrials.gov Identifier: NCT02781974 . Registered 25.05.16. Retrospectively registered.

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“…W literaturze światowej nie mamy wystarczających dowodów, aby określić jednoznaczny wpływ ćwiczeń fizycznych na złamania lub zranienia. Wyniki nie przedstawiają klinicznie znaczącej poprawy i należy je interpretować ostrożnie ze względu na niską jakość dowodów z powodu niespójnych wyników i ograniczeń badań [6].…”

Section: Wykres 7 Najczęściej Wykonywana Przez Pacientów Czynność W unclassified

Recommendation for Physical Activity for Patients Suffering from Osteoporosis

Horbacz

Zięba

Buková

et al. 2020

Fiz. vihov. sport kul’t. zdor. suchas. susp.

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Introduction. Osteoporosis is currently the most common bone disease affecting a significant part of the population. The occurrence of this disease increases with the increasing average life expectancy. One should not forget that prevention is the key component to avoid osteoporosis and one of the most important parts of the prevention are lifestyle, eating habits, adequate intake of minerals and appropriate physical activity. Along with the pharmacologic treatment, appropriate physical activity is proved to significantly mitigate the negative effects of the disease. The aim of this study is to expand the knowledge about patients´ awareness of osteoporosis and provide recommendations for physical activity for patients with osteoporosis. Methods. We approached patients suffering from osteoporosis (n=96), 78 female patients, and 18 male patients. The average age of the participants was ±65. Our research was conducted at specialized outpatient clinics in eastern Slovakia. For data collection, we used a non-standardized questionnaire that was part of the questionnaire battery explicitly designed for this research. We focused on the basic information about the health conditions including patients´ awareness of the appropriate physical activity with regard to their diseases. Based on these findings we suggested a set of recommendations for the performance of physical activity for patients suffering from osteoporosis. Results. Our findings show that 73 % of patients were informed about their health condition and most patients receive this information from their primary care physicians. 45 % of the respondents received information about the appropriate physical activity in treating osteoporosis from their primary care physicians and 22 % from the nursing staff. 21 % of respondents were not interested in any information regarding physical activity. 57 % of the patients in our sample spend leisure time gardening and 76 % of respondents spend leisure time doing household chores. Further leisure time activities included shopping (45 %) and reading (36 %). Watching TV and computer-related activities were identified by 34 % of respondents and 10 % of respondents performed recreational physical activity, especially hiking and walks. Conclusion. Most respondents received information about their diagnosis and physical activity from their physicians, nursing staff, or media. It is encouraging that patients were aware of the appropriate physical activity and they also try to learn about it through various information channels, however, only a small number of patients in our sample perform specific physical activity in their leisure time.

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Exercise for improving outcomes after osteoporotic vertebral fracture

Cited by 58 publications

References 76 publications

The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review

The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review

Physical fitness in older women with osteoporosis and vertebral fracture after a resistance and balance exercise programme: 3-month post-intervention follow-up of a randomised controlled trial

Recommendation for Physical Activity for Patients Suffering from Osteoporosis

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