Exercise for Men with Prostate Cancer: A Systematic Review and Meta-analysis

Bourke, Liam; Smith, Dianna; Steed, Liz; Hooper, Richard; Carter, Anouska; Catto, James W.F.; Albertsen, Peter C.; Tombal, Bertrand; Payne, Heather; Rosario, Derek J.

doi:10.1016/j.eururo.2015.10.047

Cited by 238 publications

(231 citation statements)

References 43 publications

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“…In endometrial, ovarian and colorectal cancer survivors, lifestyle interventions that include regular participation in physical activity are associated with positive health outcomes (45,46). Furthermore, it has been demonstrated that individuals who are physically active after being diagnosed with breast or colon cancer exhibit a higher rate of survival compared with those that are physically inactive (47).…”

Section: Discussionmentioning

confidence: 99%

Physical exercise modulates the level of serum MMP-2 and MMP-9 in patients with breast cancer

et al. 2016

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Abstract. Matrix metalloproteinases (MMPs) exhibit an important function in extracellular matrix degradation. MMPs modulate the activation of growth factors, cytokines and metastasis. At present, the effect of exercise on serum levels of MMP-2 and -9 remains unclear. The aim of the present study was to investigate the effect of various physical activities on the circulating levels of MMP-2 and -9 in breast cancer (BC) survivors and healthy subjects. A total of 66 female subjects were enrolled in the present study. The cohort included 46 BC survivors and 20 healthy subjects divided into 5 groups: Group A (17 BC survivors, participating in recreational dragon boat paddling), group B (14 BC survivors, participating in recreational physical activity), group C (15 sedentary BC survivors), group D (10 healthy subjects, participating in recreational physical activity) and group E (10 sedentary healthy subjects). ELISA assays revealed a significant increase in the level of circulating MMP-2 in group B compared with all other groups. Recreational physical activity increased the levels of MMP-9 in healthy subjects (group D vs. E), however, the differences were not statistically significant, while in the BC survivor groups the results were opposite, with exercise reducing MMP-9 levels (group B vs. C). Furthermore, a significant increase in MMP-2 was observed in group B lymph node metastasis-positive (N+) subjects compared with group A and C N+ subjects. Thus, the results of the present study indicate that various physical activities modulate the levels of circulating MMP-2 and -9 in BC survivors, and the same exercise program induces a different effect when undertaken by healthy subjects and BC survivors. These results may have important implications with regard to the selection of appropriate physical activities for BC survivors, leading to improvements to their survival and prevention of recurrence, as well as amelioration of physical function, quality of life and fatigue.

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Section: Discussionmentioning

confidence: 99%

Physical exercise modulates the level of serum MMP-2 and MMP-9 in patients with breast cancer

et al. 2016

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“…However, although recent meta-analysis has reported the benefit of exercise therapy on the cancer-specific quality of life and fatigue [7] in PCa patients, available data about the feasibility of exercise is still inconsistent. The purpose of this meta-analysis is to evaluate the role of exercise in control mental and physical changes in PCa patients receiving ADT and analyze whether the duration and the type of exercise correlate with the effect.…”

Section: Introductionmentioning

confidence: 99%

Exercise overcome adverse effects among prostate cancer patients receiving androgen deprivation therapy

Gao

He²,

Xueyang³

et al. 2017

Medicine

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Background:Prostate cancer (PCa) patients initiating androgen deprivation therapy (ADT) are suffering from adverse effects; exercise has been proposed as a treatment to relieve adverse effects of ADT, available meta-analysis has proved exercise improves quality of life, and therapy caused fatigue; recently, some high-quality trials have been conducted in order to get more assessment; we conduct an updated meta-analysis to evaluate feasibility that exercise relieves adverse effects in PCa patients initiating ADT.Materials and methods:A systematic article search was performed from Cochrane Library, MEDLINE, EMBASE, and PubMed databases up to March 10, 2017. Outcomes included changes in body composition, physical function, bone health and cardiometabolic changes. We conduct subgroup analysis to analyze the duration and type of exercise correlated with the effect and calculated using standard mean difference (SMD) and corresponding 95% confidence intervals (CI).Result:Fifteen studies involving 1135 patients were included in our meta-analysis, and significant positive effects were found in body strength (leg press (SMD: 0.78 (95%CI: 0.57–0.99, P <.00001, I2 = 0%)), chest press (SMD: 0.71 (95%CI: 0.50–0.92, P <.00001, I2 = 0%)), exercise tolerance (VO2 peak SMD: 0.35 (95%CI: 0.04–0.66, P = .03, I2 = 0%) in 6 months and SMD: 0.59 (95%CI: 0.16–1.03, P = .007, I2 = 0% over 6 months)), fatigue (SMD: 0.84 (95%CI: −1.43 to 3.10, P = .85, I2 = 51%) in 6 months and SMD: −9.3 (95%CI: −16.22 to −2.39, P = .0030, I2 = 49%) over 6 months)), ADT-caused obesity (body mass index SMD: −0.33 (95%CI: −0.55 to −0.12, P = .002, I2 = 38% in 6 months and SMD: −0.59 95%CI: −1.02 to 0.17, P = .006, I2 = 25% over 6 months)), and sex function (SMD: 0.66 (95%CI: 0.35–0.97, P <.00001, I2 = 2%). There were no evidence of benefit for cardiometabolic changes and bone health. No systematic difference was observed between resistance exercise training (RET) and aerobic exercise training (AET) in ADT-caused obesity, fatigue, and exercise toleranceConclusion:Exercise can significantly improve the upper and lower muscle strength, increase exercise tolerance, help PCa patients receiving ADT control their body fat mass, BMI, and keep the sex function. ADT-related fatigue is correlated with exercise duration time. No differences were observed in LBM, bone mineral density, and any other metabolic blood markers. Available data show that there is no difference between AET and RET.

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“…The results of a systematic review and meta-analysis support the hypotheses that exercise approaches improve PCa-related quality of life and fatigue, submaximal physical fitness, and lower body strength (31). Another review involving observational epidemiological studies has shown associations between physical activity and PCa risk.…”

Section: Discussionmentioning

confidence: 58%

The Importance of Preventive Physiotherapy in Patients Diagnosed with Prostate Cancer

Özdemir¹,

Keser²,

Şen³

et al. 2016

jus

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AmaçProstat kanseri (PKa) 50 yaş ve üzeri erkeklerde görülmektedir. Görülme sıklığı artan yaş ile doğru orantılı olarak artmaktadır. Uygulanan tarama programları ve tedaviler sayesinde PKa hastalarının sağkalım oranları yükselmektedir. Artan yaşam beklentileri bu hasta grubunda yaşam kalitesi, kas kuvveti ve fiziksel aktivite düzeyinde azalmaya; yorgunluk ve uyku problemlerinde artmaya neden olabilir. Bu semptomların oluşmasını önlemek amacıyla PKa hastalarında koruyucu fizyoterapi yöntemleri uygulanabilir. Bu çalışmanın amacı, PKa tanılı hastaların koruyucu fizyoterapiye olan yaklaşımlarını incelemektir. Gereç ve YöntemGazi Üniversitesi Tıp Fakültesi, Üroloji Anabilim Dalı'nda PKa tanısı alan hastalar, Sağlık Bilimleri Fakültesi Fizyoterapi ve Rehabilitasyon Anabilim Dalı Onkolojik Rehabilitasyon Ünitesi'nde uygulanan koruyucu fizyoterapi hizmetlerine katılmaları önerilerek çalışmaya davet edildi. BulgularDavet edilen 344 kişiden sadece 20'si (%5,8) çalışmaya katıldı. Yirmi (%5,8) hasta çalışmaya katılmayı kabul etmesine rağmen randevusuna gelmedi. Geriye kalan 304 (%88,4) hasta çeşitli sebeplerden dolayı çalışmaya katılmadı. SonuçKatılım oranının bu kadar düşük olmasının sebebi PKa hastalarının koruyucu fizyoterapi hakkında yeterli bilgiye sahip olmamaları olabilir. Bu çalışmanın sonuçları, PKa hastalarında koruyucu fizyoterapi uygulamalarının daha tanınır hale getirilmesinin gerekliliğini vurgulamıştır. Anahtar KelimelerFizyoterapi ve rehabilitasyon, farkındalık, kanser rehabilitasyonu ObjectiveProstate cancer (PCa) is observed in men aged 50 years and older. The incidence increases in parallel to aging. Survival rate for PCa increases with effective screening programs and therapies. Elongated life expectancy may lead to a decrease in quality of life, muscle strength and physical activity level; an increase in fatigue and sleep problems. To preclude the occurrence of these symptoms, the preventive physiotherapy approaches may be used in PCa patients. The aim of this study was to investigate the attitude of patients with PCa towards preventative physiotherapy approaches. Materials and MethodsPatients who were diagnosed with PCa in Gazi University Faculty of Medicine, Department of Urology were invited to participate in the preventive physiotherapy services provided in Gazi University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Oncologic Rehabilitation Unit. ResultsThree hundred forty-four patients were invited, only 20 (5.8%) patients participated in the study. Twenty (5.8%) patients did not attend the appointment despite agreeing to participate in the study. Other 304 (88.4%) patients did not join the study for several reasons. ConclusionThe reason for low participation rate may be inadequate information of PCa patients about preventive physiotherapy. The results of this study highlight the need for making preventive physiotherapy applications recognizable for PCa patients. KeywordsPhysiotherapy and rehabilitation, awareness, cancer rehabilitation Only 5.8% of prostate cancer ...

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Exercise for Men with Prostate Cancer: A Systematic Review and Meta-analysis

Cited by 238 publications

References 43 publications

Physical exercise modulates the level of serum MMP-2 and MMP-9 in patients with breast cancer

Physical exercise modulates the level of serum MMP-2 and MMP-9 in patients with breast cancer

Exercise overcome adverse effects among prostate cancer patients receiving androgen deprivation therapy

The Importance of Preventive Physiotherapy in Patients Diagnosed with Prostate Cancer

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