Exercise for Patients with Cancer: Reducing Disease-Related Fatigue

Arnold, Meaghan; Taylor, Nicholas F.

doi:10.2217/fon.10.188

Cited by 5 publications

(6 citation statements)

References 20 publications

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“…In the posttest, EG related less limitations and more physical competences and skills, as well as better body image and functional quality of life. Therefore, the EG presented higher sleep efficiency (78% in the pretest to 94% in the post-test, which means more time lying in bed actually asleep) and decreased fatigue, which is one of the most frequent adverse and stressful events of cancer treatment [33]. Retention rates averaged 86% [4], similar as our results.…”

Section: Discussionsupporting

confidence: 88%

Resistance Exercise Program During Breast Cancer Treatment: A Feasibility Study

et al. 2016

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Background: In the last two decades, physical training has been recognized as an important means of prevention and rehabilitation for patients with breast cancer. In Brazil, physical exercise for patients with breast cancer is a new area of study. We aimed to investigate the feasibility of implementing a resistance exercise program for patients undergoing breast cancer treatment and to examine the effects of the resistance exercise program on psychological and physical outcomes. Methods: We conducted a non-randomized controlled trial. Eleven women (55.08 ± 7.8 years) undergoing radiotherapy and hormone therapy for breast cancer were divided into exercise group (n = 6) and control group (n = 5). The feasibility was evaluated by training load performed by each patient compared to the total training load prescription. The resistance exercise program consisted of 12 weeks and 36 sessions (3x per week), and intensity between 50 and 70% of one maximum repetition. Fitness (6-minute walk test), quality of life (EORTC QLQ-C30), mood states (BRUMS), sleep quality (Pittsburgh), and body image (Body Image after Breast Cancer) were investigated before and after resistance exercise program. Data were analyzed by comparison inter and intra groups (p=0.05). Findings: The resistance exercise program implementation was feasible (>80%). There were no adverse events due to the resistance exercise program, and the adherence averaged 83.6% with no dropouts. Twelve weeks of resistance exercise appeared to have positive effects on quality of life, sleep quality, physical fitness, body image, and fatigue in patients undergoing breast cancer treatment. Conclusions: The implementation of a resistance exercise program in a university in the south of Brazil proved to be feasible, tolerable,

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Section: Discussionsupporting

confidence: 88%

Resistance Exercise Program During Breast Cancer Treatment: A Feasibility Study

et al. 2016

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Section: Introductionmentioning

confidence: 99%

“…[5,6] For fatigue reduction, most patients are given alternative and complementary, including scientific sports training, nutritional supplements, Chinese medicine supplements, etc. [7,8] Ginseng, a kind of medicine or health food widely used to treat fatigue in the world, has 2 major subgroup, Korean ginseng and American ginseng. Ginseng is the dried root of the Araliaceae plant ginseng, a traditional nourishing and health-preserving precious medicinal material in China, which has the functions of invigorating vitality, rejuvenating the pulse, replenishing the spleen and lungs, nourishing body fluid, nourishing blood, and soothing mind.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of ginseng supplements on disease-related fatigue: A systematic review and meta-analysis

Zhu

Zhang

et al. 2022

Medicine

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Background: Ginseng has been believed to provide energy, physical health, and well-being to patients for hundreds of years. Fatigue is a multidimensional symptom with unknown etiology and varying severity, and lots of patients suffer from fatigue. Methods: We search for research of ginseng treatment of disease-related fatigue in adult patients in Pubmed, Embase, Medline, and Cochrane library. Two independent reviewers assessed included studies and met to develop consensus on included studies. And we used Review Manager 5.3 software to evaluate the risk of bias. Results: The present meta-analysis included 12 randomized controlled trial containing 1298 patients. In the fixed-effect meta-analysis of 12 randomized controlled trial, ginseng supplements had a statistically significant efficacy on disease-related fatigue reduction (standardized mean difference = 0.33, 95% confidence interval = 0.44–0.22). Conclusions: The use of ginseng supplements is benefit for patients to reduce disease-related fatigue.

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“…Regardless, glucocorticoid therapy is a short-term option at best for cancer-related fatigue, because prolonged use induces insulin resistance, increased adiposity [ 34 , 35 , 36 ], muscle wasting [ 37 ], brain atrophy, and diminished neurogenesis [ 38 , 39 ]. Chronic exercise training is the most effective treatment for CRF [ 2 , 8 , 40 , 41 , 42 , 43 , 44 , 45 ], suggesting that increased muscle activity triggers cellular and metabolic adaptations that counteract factors responsible for CRF. Although diet has received little attention in CRF, diet quality has been associated with reduced fatigue in a cross-sectional study of breast cancer survivors following primary treatment [ 46 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Adjunct Testosterone on Cancer-Related Fatigue: An Ancillary Analysis from a Controlled Randomized Trial

et al. 2022

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Many cancer patients undergoing treatment experience cancer-related fatigue (CRF). Inflammatory markers are correlated with CRF but are not routinely targeted for treatment. We previously demonstrated in an NIH-funded placebo-controlled, double-blind, randomized clinical trial (NCT00878995, closed to follow-up) that seven weekly injections of 100 mg adjunct testosterone preserved lean body mass in cancer patients undergoing standard-of-care treatment in a hospital setting. Because testosterone therapy can reduce circulating proinflammatory cytokines, we conducted an ancillary analysis to determine if this testosterone treatment reduced inflammatory burden and improved CRF symptoms and health-related quality of life. Randomization was computer-generated and managed by the pharmacy, which dispensed testosterone and placebo in opaque syringes to the administering study personnel. A total of 24 patients were randomized (14 placebo, 10 testosterone), and 21 were included in the primary analysis (11 placebo, 10 testosterone). Testosterone therapy did not ameliorate CRF symptoms (placebo to testosterone difference in predicted mean multidimensional fatigue symptom inventory scores: −5.6, 95% CI: −24.6 to 13.3), improve inflammatory markers, or preserve health-related quality of life and functional measures of performance in late-stage cancer patients.

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Exercise for Patients with Cancer: Reducing Disease-Related Fatigue

Cited by 5 publications

References 20 publications

Resistance Exercise Program During Breast Cancer Treatment: A Feasibility Study

Resistance Exercise Program During Breast Cancer Treatment: A Feasibility Study

Efficacy of ginseng supplements on disease-related fatigue: A systematic review and meta-analysis

Impact of Adjunct Testosterone on Cancer-Related Fatigue: An Ancillary Analysis from a Controlled Randomized Trial

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