Exercise improves the outcome of anticancer treatment with ultrasound-hyperthermia-enhanced nanochemotherapy and autophagy inhibitor

Chiang, Chi-Feng; Wang, Zi-Zong; Hsu, Yu-Hone; Miaw, Shi‐Chuen; Lin, Win-Li

doi:10.1371/journal.pone.0288380

Cited by 2 publications

(1 citation statement)

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“…One such compound is PEGylated (poly(ethylene glycol)-coated) liposomal DOX (PLD) with a prolonged circulation time and increased microvascular permeability but without apparent cardiac toxicity [42,57]. A combination of CQ with PLD and pulse-wave ultrasound hyperthermia (pUH), a scheme developed to enhance the delivery of drugs to subcutaneous 4T1 breast cancer explant in BALB/c mice, induced the long-term suppression of tumor growth in comparison to CQ monotherapy or PLD + pUH treatment [58,59]. In HeLa cells, CQ enhanced the cytotoxicity of DOX encapsulated in pH-sensitive liposomes (SpHL-DOX) created to accelerate drug delivery in acidic environments [60].…”

Section: Chloroquine and Doxorubicin (Dox)mentioning

confidence: 99%

Chloroquine and Chemotherapeutic Compounds in Experimental Cancer Treatment

Agalakova

2024

IJMS

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Chloroquine (CQ) and its derivate hydroxychloroquine (HCQ), the compounds with recognized ability to suppress autophagy, have been tested in experimental works and in clinical trials as adjuvant therapy for the treatment of tumors of different origin to increase the efficacy of cytotoxic agents. Such a strategy can be effective in overcoming the resistance of cancer cells to standard chemotherapy or anti-angiogenic therapy. This review presents the results of the combined application of CQ/HCQ with conventional chemotherapy drugs (doxorubicin, paclitaxel, platinum-based compounds, gemcitabine, tyrosine kinases and PI3K/Akt/mTOR inhibitors, and other agents) for the treatment of different malignancies obtained in experiments on cultured cancer cells, animal xenografts models, and in a few clinical trials. The effects of such an approach on the viability of cancer cells or tumor growth, as well as autophagy-dependent and -independent molecular mechanisms underlying cellular responses of cancer cells to CQ/HCQ, are summarized. Although the majority of experimental in vitro and in vivo studies have shown that CQ/HCQ can effectively sensitize cancer cells to cytotoxic agents and increase the potential of chemotherapy, the results of clinical trials are often inconsistent. Nevertheless, the pharmacological suppression of autophagy remains a promising tool for increasing the efficacy of standard chemotherapy, and the development of more specific inhibitors is required.

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Section: Chloroquine and Doxorubicin (Dox)mentioning

confidence: 99%

Chloroquine and Chemotherapeutic Compounds in Experimental Cancer Treatment

Agalakova

2024

IJMS

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The Therapeutic Potential of Physical Exercise in Cancer: The Role of Chemokines

Buzaglo,

Telles,

Araújo

et al. 2024

IJMS

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The global increase in cancer cases and mortality has been associated with inflammatory processes, in which chemokines play crucial roles. These molecules, a subfamily of cytokines, are essential for the migration, adhesion, interaction, and positioning of immune cells throughout the body. Chemokines primarily originate in response to pathogenic stimuli and inflammatory cytokines. They are expressed by lymphocytes in the bloodstream and are divided into four classes (CC, CXC, XC, and CX3C), playing multifaceted roles in the tumor environment (TME). In the TME, chemokines regulate immune behavior by recruiting cells such as tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), which promote tumor survival. Additionally, they directly influence tumor behavior, promoting pathological angiogenesis, invasion, and metastasis. On the other hand, chemokines can also induce antitumor responses by mobilizing CD8+ T cells and natural killer (NK) cells to the tumor, reducing pro-inflammatory chemokines and enhancing essential antitumor responses. Given the complex interaction between chemokines, the immune system, angiogenic factors, and metastasis, it becomes evident how important it is to target these pathways in therapeutic interventions to counteract cancer progression. In this context, physical exercise emerges as a promising strategy due to its role modulating the expression of anti-inflammatory chemokines and enhancing the antitumor response. Aerobic and resistance exercises have been associated with a beneficial inflammatory profile in cancer, increased infiltration of CD8+ T cells in the TME, and improvement of intratumoral vasculature. This creates an environment less favorable to tumor growth and supports the circulation of antitumor immune cells and chemokines. Therefore, understanding the impact of exercise on the expression of chemokines can provide valuable insights for therapeutic interventions in cancer treatment and prevention.

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Exercise improves the outcome of anticancer treatment with ultrasound-hyperthermia-enhanced nanochemotherapy and autophagy inhibitor

Cited by 2 publications

References 80 publications

Chloroquine and Chemotherapeutic Compounds in Experimental Cancer Treatment

Chloroquine and Chemotherapeutic Compounds in Experimental Cancer Treatment

The Therapeutic Potential of Physical Exercise in Cancer: The Role of Chemokines

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