“…It is clear that physical activity in MS has a positive influence, as demonstrated in both experimental and clinical settings (Dalgas et al, 2009;Rossi et al, 2009;Latimer-Cheung et al, 2013). Whereas earlier studies highlighted the beneficial effects of exercise at a peripheral level (i.e., osteoarticular/muscular and cardiovascular systems), (Dalgas et al, 2009;Latimer-Cheung et al, 2013) it has become increasingly clear that physical activity has a major effect on brain reorganization as well (Prakash et al, 2007(Prakash et al, , 2010Motl et al, 2015;El-Sayes et al, 2019;Guo et al, 2020;Lozinski and Yong, 2020). Neuroplasticity, intended as the ability of the brain to modify itself at a structural and functional level in response to aging, experiences and environmental stimuli, occurs throughout the lifespan, as evidenced by animal and MRI based-human studies (Maguire et al, 2000;Draganski et al, 2004;Bengtsson et al, 2005;Zatorre et al, 2012;Garthe et al, 2016;Lambert et al, 2019).…”