Exercise in the Prevention of Osteoporosis-Related Fractures

Beck, Belinda R.; Winters-Stone, Kerri M.

doi:10.1007/978-3-319-69287-6_11

Cited by 5 publications

(7 citation statements)

References 284 publications

(248 reference statements)

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“…Unloading the skeleton, for instance because of limb immobilization, prolonged bed rest, or spinal cord injury, causes bone loss. [3] However, the association of PA with bone mineral density (BMD) and bone microarchitecture depends on activity type, intensity, duration, and loading. [3] From a cross-sectional study of 15 female tennis players with a mean age of 20 years, the racquet arm had thicker cortices and thicker trabeculae at the distal radius compared with the nonracquet arm.…”

Section: Introductionmentioning

confidence: 99%

“…[3] However, the association of PA with bone mineral density (BMD) and bone microarchitecture depends on activity type, intensity, duration, and loading. [3] From a cross-sectional study of 15 female tennis players with a mean age of 20 years, the racquet arm had thicker cortices and thicker trabeculae at the distal radius compared with the nonracquet arm. [4] Similarly, a prospective study of 91 female recruits with a mean age of 22 years found increased cortical and trabecular thickness at the distal tibia as a response to 8 weeks of basic combat training.…”

Section: Introductionmentioning

confidence: 99%

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Is There a Causal Relationship between Physical Activity and Bone Microarchitecture? A Study of Adult Female Twin Pairs

Nissen

Esser

Bui

et al. 2023

J of Bone & Mineral Res

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The reasons for the association between physical activity (PA) and bone microarchitecture traits are unclear. We examined whether these associations were consistent with causation and/or with shared familial factors using a cross-sectional study of 47 dizygotic and 93 monozygotic female twin pairs aged 31-77 years. Images of the nondominant distal tibia were obtained using high-resolutionperipheral quantitative computed tomography. The bone microarchitecture was assessed using StrAx1.0 software. Based on a self-completed questionnaire, a PA index was calculated as a weighted sum of weekly hours of light (walking, light gardening), moderate (social tennis, golf, hiking), and vigorous activity (competitive active sports) = light + 2 * moderate + 3 * vigorous. We applied Inference about Causation through Examination of FAmiliaL CONfounding (ICE FALCON) to test whether cross-pair cross-trait associations changed after adjustment for within-individual associations. Within-individual distal tibia cortical cross-sectional area (CSA) and cortical thickness were positively associated with PA (regression coefficients [β] = 0.20 and 0.22), while the porosity of the inner transitional zone was negatively associated with PA (β = À0.17), all p < 0.05. Trabecular volumetric bone mineral density (vBMD) and trabecular thickness were positively associated with PA (β = 0.13 and 0.14), and medullary CSA was negatively associated with PA (β = À0.22), all p ≤ 0.01. Cross-pair crosstrait associations of cortical thickness, cortical CSA, and medullary CSA with PA attenuated after adjustment for the within-individual association (p = 0.048, p = 0.062, and p = 0.028 for changes). In conclusion, increasing PA was associated with thicker cortices, larger cortical area, lower porosity of the inner transitional zone, thicker trabeculae, and smaller medullary cavities. The attenuation of cross-pair crosstrait associations after accounting for the within-individual associations was consistent with PA having a causal effect on the improved cortical and trabecular microarchitecture of adult females, in addition to shared familial factors.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Is There a Causal Relationship between Physical Activity and Bone Microarchitecture? A Study of Adult Female Twin Pairs

Nissen

Esser

Bui

et al. 2023

J of Bone & Mineral Res

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“… 18 19 Moreover, regular, long-term moderate-to-high-intensity exercises can positively influence bone metabolism and are more likely to reduce the risk of osteoporotic fracture. 10 However, due to the differences in medical accessibility, 20 most patients at high risk of osteoporotic fracture cannot be identified and receive few regular and professional exercises. Hence, the long-term efficacy of exercise interventions is difficult to assess in women at high risk of fracture.…”

Section: Introductionmentioning

confidence: 99%

“…Many OP-related fractures are preventable and treatable 6 9 10. Exercise has been recommended as a low-cost and effective non-pharmacological strategy for improving bone strength 11–13.…”

Section: Introductionmentioning

confidence: 99%

“…There is considerable evidence suggesting that moderate-to-high-intensity impact and muscle strengthening exercises are more effective than low-impact exercises in maintaining improvements in measures such as bone mineral density (BMD)14–17; however, evidence on fracture risk is limited 18 19. Moreover, regular, long-term moderate-to-high-intensity exercises can positively influence bone metabolism and are more likely to reduce the risk of osteoporotic fracture 10. However, due to the differences in medical accessibility,20 most patients at high risk of osteoporotic fracture cannot be identified and receive few regular and professional exercises.…”

Section: Introductionmentioning

confidence: 99%

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Effects of tele-exercise rehabilitation intervention on women at high risk of osteoporotic fractures: study protocol for a randomised controlled trial

Liang

et al. 2022

BMJ Open

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IntroductionPremenopausal and postmenopausal osteoporosis and associated fragility fractures are major public health problems. Exercise, especially moderate-to-high-intensity impact exercise, has been recommended as an effective, low-cost non-pharmacological strategy for bone strength improvement; however, evidence on fracture risk is limited. In addition, maintaining regular training is currently a problem. Therefore, this study aims to conduct a randomised controlled trial of moderate-to-high-intensity tele-exercise intervention using a tele-rehabilitation app and quantify its effects on vertical fracture and fall prevention in women at high risk of osteoporotic fractures.Methods and analysisIn this multicentre, randomised controlled trial, 794 women at high risk of osteoporotic fractures will be recruited and randomised into either the tele-exercise rehabilitation or control group. Participants in the control group will receive routine remote rehabilitation, while those in the intervention group will be provided with a 6-month tele-exercise rehabilitation. The primary outcomes are the percentage of participants with one or more new vertebral fractures and incidence of falls. Intention-to-treat, full analysis set and per-protocol approaches will be used for outcome analyses.Ethics and disseminationThe study was approved by the biomedical research ethics committee of the West China Hospital of Sichuan University (2021-579). Written informed consent will be obtained from each participant after agreeing to participate in the study. The study findings will be presented at national and international scientific conferences and published in peer-reviewed journals. Results are propagated regardless of the magnitude or direction of the impact. Authorship is assigned according to authorship guidelines as defined by the International Board of Medical Journal Editors, and each author’s role is based on journal requirements for publication.Trial registration numberThe study was registered with the Chinese Clinical Trial Registry (ChiCTR2200058780) prior to recruitment (May 2022).

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Effect of Tai Chi on bone mineral density in postmenopausal women: A systematic review and meta-analysis of randomized control trials

Feng-hu

Wang

2017

Journal of the Chinese Medical Association

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Exercise in the Prevention of Osteoporosis-Related Fractures

Cited by 5 publications

References 284 publications

Is There a Causal Relationship between Physical Activity and Bone Microarchitecture? A Study of Adult Female Twin Pairs

Is There a Causal Relationship between Physical Activity and Bone Microarchitecture? A Study of Adult Female Twin Pairs

Effects of tele-exercise rehabilitation intervention on women at high risk of osteoporotic fractures: study protocol for a randomised controlled trial

Effect of Tai Chi on bone mineral density in postmenopausal women: A systematic review and meta-analysis of randomized control trials

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