Exercise in the setting of hematopoietic stem cell transplantation

Wiskemann, Joachim

doi:10.1007/s11556-012-0116-2

Cited by 5 publications

(9 citation statements)

References 33 publications

(48 reference statements)

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“…The mean percentage of CD34 positive cells was highest on the 6 th postoperative day which could be due to the influence of the mobilization of HSCs and the reason could be attributed to the inactivation of the chemokine Stromal Cell-Derived Factor-1 (SDF-1) CXCL12, interleukin-8 (IL-8)/CXCL8 along with the proteolytic activity of elastase, cathepsin G, proteinase 3, CD26 and metalloproteinase (MMP)-2 and 9 which disrupt the SDF-1/CXCR 4 axis resulting in HSCs release [37]. The pattern of increase was comparable with post-exercise induced stem cell mobilization [13]. Though the insult of hypoxia and stress was reflected in terms of plasma cortisol and stress leukogram during anesthesia and surgery; mobilization of CD34 positive HSCs was noticed only during postoperative tissue reparative process or healing period irrespective of the anesthetic regimens.…”

Section: Resultsmentioning

confidence: 89%

“…5 ml of blood was collected in Ethylene-Diamine-Tetra-Acetic-acid (EDTA) vial from the cannulated jugular vein of horses. The collected blood was diluted with equal parts (1:1) of Phosphate Buffer Solution (PBS) and gently mixed [13]. To 4 ml of ficoll medium, the diluted blood was gently overlaid and centrifuged at 1600 rpm for 20 minutes.…”

Section: Equine Peripheral Hsc/progenitor Cell Mobilization/mscmentioning

confidence: 99%

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Effect of Stress Induced by Anesthesia and Surgery on Peripheral Blood Mobilization of Stem Cells in Horses

Gutti¹,

William²,

George³

et al. 2018

J Stem Cell Res Ther

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Objective: The study was conducted to evaluate the effect of stress induced by general anesthesia and surgery on the peripheral mobilization of stem cells in horses. Methods: The study was conducted in 12 horses that reported for elective surgical procedures warranting general anesthesia and were randomly divided into group I and group II each consisting of 6 horses. The study included evaluation of plasma cortisol level, stress leukogram and mobilization of peripheral blood Hematopoietic Stem Cells (HSCs), Mesenchymal Stem Cells (MSCs)/progenitor cells. Group I horses were pre-medicated with a butorphanoldexmedetomidine-acepromazine combination and further induced and maintained with ketamine-midazolam. Group II horses were pre-medicated with butorphanol-xylazine and induced and maintained with ketamine alone. Results: The change in the pattern of the differential count in terms of stress leukogram was marked when the horses were induced and maintained with ketamine. The mean percentage of CD34 positive cells in pre-anesthesia, during anesthesia and post-anesthesia were 0.13 ± 0.00, 0.31 ± 0.02 and 0.64 ± 0.03 in group I and in group II, 0.12 ± 0.00, 0.30 ± 0.01 and 0.70 ± 0.03 respectively. Similarly, the mean percentage of CD105 positive cells in preanesthesia, during anesthesia and post-anesthesia were 0.01 ± 0.00, 0.01 ± 0.00 and 0.02 ± 0.00 in group I and in group II, 0.01 ± 0.00, 0.01 ± 0.00 and 0.03 ± 0.00 respectively. The Perusal of mean revealed a significant increase in CD34 positive cells in both the groups on the 6 th postoperative day and revealed no significant increase in CD105 positive cells in both the groups. Conclusion: Though the stress indicators in terms of plasma cortisol level and stress leukogram were high after sedation and during anesthesia; mobilization of HSCs was appreciated only after 6 th postoperative day indicating mobilization was occurring during the reparative and healing period.

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Section: Resultsmentioning

confidence: 89%

Section: Equine Peripheral Hsc/progenitor Cell Mobilization/mscmentioning

confidence: 99%

Effect of Stress Induced by Anesthesia and Surgery on Peripheral Blood Mobilization of Stem Cells in Horses

Gutti¹,

William²,

George³

et al. 2018

J Stem Cell Res Ther

View full text Add to dashboard Cite

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“…65 Exercise, as supportive care for HSCT patients, has a significant benefit for physical performance and results in the rapid recovery of the immune system and reducing the side effect of the therapy. 66 Furthermore, improvement of QOL, especially emotional aspects, is attributed to exercising before and after HSCT. 66…”

Section: Weight Nutrition and Exercisementioning

confidence: 99%

“…66 Furthermore, improvement of QOL, especially emotional aspects, is attributed to exercising before and after HSCT. 66…”

Section: Weight Nutrition and Exercisementioning

confidence: 99%

A concise review on factors influencing the hematopoietic stem cell transplantation main outcomes

Rafiee

Abbasi

Rafieemehr

et al. 2021

Health Science Reports

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Background and aims As a curative procedure, hematopoietic stemcell transplantation (HSCT) is an approved treatment for many malignant orbenign hematologic and non‐hematologic diseases. There are different outcomes of HSCT, as well as several parameters influencing these outcomes. Methods We had searched scientific sources like Web ofScience and PubMed with a combination of keywords such as HSCT, engraftment,survival, outcomes, etc. Totally, 80 articles were included. Results Here we have reviewed the effective factors onmain outcomes of HSCT including engraftment, survival, graft versus hostdisease, and Mobilization. Also, the prediction of hematological reconstitutionand some novel suggestions leading to better outcomes are reviewed. Conclusion The study will be applicable for improvedmanagement of autologous and allogeneic HSCT process to increase the procedureefficiency.

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“…Whereas physical exercise affects physical functioning and fatigue, there is no consensus about positive effects on psycho-emotional components of quality of life [15,18,19]. No conclusive results have been found regarding depression, anxiety, and sleep disturbance among hematologic patients [14], and no significant results were reported about the impact of a physical exercise program on improving social functioning for patients undergoing HSCT [15].…”

Section: Complementary Therapies To Enhance Health-related Quality Ofmentioning

confidence: 99%

Adapted physical activity and cardiac coherence in hematologic patients (APACCHE): study protocol for a randomized controlled trial

Fournié¹,

Bouscaren²,

Dalleau³

et al. 2020

BMC Sports Sci Med Rehabil

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Background: Hematologic malignancies and their treatments are recognized for their significant long-term adverse effects on health-related quality of life. As a part of cancer treatment, physical exercise is known to improve physical functioning, but there are still questions regarding its impact on psychological and emotional functioning. Nonetheless, heart rate variability biofeedback (HRVB) is recognized for its positive effects on autonomic nervous system balance and emotional self-regulation. The Adapted Physical Activity and Cardiac Coherence in Hematologic Patients (APACCHE) protocol is a randomized, controlled superiority trial designed to evaluate the effects of HRBV training combined with an adaptive physical activity (APA) program compared to APA alone on the post-treatment quality of life of adult hematologic patients. Methods: Seventy patients aged 18-70 years, with various forms of hematological malignancies, in posttreatment remission within six months prior to beginning the study and who have been prescribed APA by a hematologist, will be randomly allocated in a 1:1 ratio to two 12-week treatment groups: HRVB + APA versus APA alone. APA sessions will consist of aerobic and resistance training for 1-h twice weekly. The HRVB training will consist of controlled breathing exercises with biofeedback of heart rate variability for 10 sessions and will include a daily home-based practice. The primary outcome will be to evaluate health-related quality of life (QLQ-C30, SF-36). The secondary outcomes will be to evaluate fatigue (MFI-20); anxiety and depression (HADS); clinical status with blood pressure, progression-free survival, overall survival, and body mass index; heart rate variability level and cardiac coherence score. All of these assessments will be evaluated initially (T1), 6 weeks after (T2), at the end of the 12 weeks (T3), and then at a 12-week post-intervention follow-up (T4).

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Exercise in the setting of hematopoietic stem cell transplantation

Cited by 5 publications

References 33 publications

Effect of Stress Induced by Anesthesia and Surgery on Peripheral Blood Mobilization of Stem Cells in Horses

Effect of Stress Induced by Anesthesia and Surgery on Peripheral Blood Mobilization of Stem Cells in Horses

A concise review on factors influencing the hematopoietic stem cell transplantation main outcomes

Adapted physical activity and cardiac coherence in hematologic patients (APACCHE): study protocol for a randomized controlled trial

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