Exercise-induced airway obstruction in relation to chronic obstructive lung disease

Gimeno, F.; Berg, Wilhelm; Steenhuis, E. J.; Vries, K. de; Peset, R; Sluiter, Hj

doi:10.1136/thx.29.1.16

Cited by 2 publications

(3 citation statements)

References 10 publications

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“…Anderson, Connolly, and Godfrey (1971) have shown that free-range running is a slightly more potent stimulus to induce postexercise bronchoconstriction than treadmill running. Treadmill walking did not induce increased lability in a group of CF children reported by Heimlich, Strick, and Busser (1966).…”

Section: Discussionmentioning

confidence: 75%

“…Acute airways obstruction in CF patients may differ in some cases from that in asthma in its mechanism, which may be similar to that in chronic obstructive bronchitis. Gimeno et al, (1974) found that exercise-induced airways obstruction can be a manifestation of disease associated with chronic airways obstruction and independent of the response ILE V Skin and exercise tests in relatives of CF patients, compared* with relatives of patients with wheezy bronchitis and asthma and relatives of controls.…”

Section: Discussionmentioning

confidence: 96%

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Prevalence of atopy and exercise-induced bronchial lability in relatives of patients with cystic fibrosis.

Counahan¹,

Mearns²

1975

Archives of Disease in Childhood

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Counahan, R., and Mearns, M. B. (1975). Archives Abnormal exercise-induced bronchial lability and skin atopy have been shown in patients with cystic fibrosis (CF). Day and Mearns (1973) reported that only 27% of 52 children with CF had normal bronchial lability in response to exercise, and McCarthy, Pepys, and Batten (1969) found that 43 % of 57 CF patients had positive skin reactions to common allergens. A higher than normal prevalence of increased bronchial lability and skin atopy has been shown in the relatives of children with asthma and of infants with wheezy bronchitis (Konig and Godfrey, 1973a, b). The present study was done to determine the prevalence of abnormal bronchial lability and skin atopy in children with CF and their first-degree relatives.Subjects and methods Thirty-five children with CF and 59 first-degree relatives (37 parents and 22 sibs) were studied. The children attended this hospital between July 1973 and January 1974 and at the times of testing they were free of acute infection. The relatives were all volunteers and the purpose of the study was explained to them. Some ofthe relatives of patients were too young to be exercised, and some of the younger patients and relatives refused skin testing. The mean age of the patients tested was 10 2 years (4-18), sibs 11 5 years (6-18), and parents 37-3 years (27-54). Clinical histories were taken from the relatives and they were classiffied as being atopic (past or present asthma, hayfever, allergic rhinitis, infantile or flexural eczema) or healthy. Smoking habits were recorded. Skin testing was carried out on patients and relatives by prick test with a control and the following allergens: Dermatophagoides pteronyssinus, milk, cat fur, dog hair, early summer flower pollens, Aspergillus fwnigatus and mixed aspergilli (Bencard M5 combining Asperigillus amsteldami, niger, and terreus).Exercise tests were performed by the subjects running on a treadmill for 6 minutes at a slope of 10 degrees and at a speed of 3-4 mph, the speed being adjusted to give a pulse rate of approximately 170/min (Connolly and Godfrey, 1970). Before testing the patients were given routine percussion physiotherapy. The peak expiratory flow rate (PEFR)

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 96%

Prevalence of atopy and exercise-induced bronchial lability in relatives of patients with cystic fibrosis.

Counahan¹,

Mearns²

1975

Archives of Disease in Childhood

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“…In our opin ion, EIA may be considered as a symptom of non-specific bronchial hyperreactivity. The primary mechanism remains unclear [7], Many drugs used to treat COPD have been shown to inhibit EIA. Most previous studies of drugs in EIA have not com pared different agents in the same subjects [8,9], The degree to which pharmacologi cal agents inhibit EIA is not only impor tant therapeutically but may also provide clues to the underlying cause of EIA.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Disodium Cromoglycate, Terbutaline and Thiazinamium in the Prevention of Exercise-Induced Asthma and Its Relation to Non-Specific Bronchial Responsiveness

Gimeno¹,

Vanveenen²,

Steenhuis³

et al. 1985

Respiration

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The protective effect of pre-exercise treatment with disodium cromoglycate (DC), terbutaline sulphate (TS) and thiazinamium methylsulphate (TM) on exercise-induced asthma (EIA) was investigated. Thirty-one adults each exercised for over 6 min on a bicycle ergometer. Each subject performed five tests. The first and last exercise tests served as controls. A profile of bronchial reactivity based on the combination of hyperreactivity – as measured by acetylcholine (a), histamine (h) and propranolol (p) – was drawn up. The following combinations and frequencies were based on the response (+ or -) in hyperreactivity studies: group (h⁺, a⁺, p⁺) was present in 21 of the 31 patients studied, group (h_-, a⁺, p⁺) in 6 patients, group (h⁺, a⁺, p^-) in 2 patients and group (h^-, a⁺, p^-) in 2 patients. The proportion of patients effectively protected from their EIA was 80% for TS, 60% for DC and 40% for TM. These findings suggest that there exists a consistent heterogeneity in the patients’ response to exercise, possibly related to the individual distribution of receptors leading to bronchial hyperreactivity.

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Exercise-induced airway obstruction in relation to chronic obstructive lung disease

Cited by 2 publications

References 10 publications

Prevalence of atopy and exercise-induced bronchial lability in relatives of patients with cystic fibrosis.

Prevalence of atopy and exercise-induced bronchial lability in relatives of patients with cystic fibrosis.

Comparison of Disodium Cromoglycate, Terbutaline and Thiazinamium in the Prevention of Exercise-Induced Asthma and Its Relation to Non-Specific Bronchial Responsiveness

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