2020
DOI: 10.1186/s12933-020-01058-9
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Exercise-induced albuminuria increases over time in individuals with impaired glucose metabolism

Abstract: Background: Exercise induced albuminuria (EiA) is elevated in patients with metabolic dysfunction and diabetes, and may serve as an early biomarker for endothelial dysfunction and "kidney reserve". However, the change in EiA levels over time and its interaction with metabolic dysfunction and glucose metabolism has never been studied. Therefore, we sought to determine EiA levels over time in a cohort of individuals attending a routine annual health survey. Methods: We prospectively enrolled 412 patients attendi… Show more

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“…Similarly, further investigation of this anomaly will be important for understanding physiological excretion levels postexercise. Further, this observation supports the possibility that postexercise α1-AGP excretion, like albumin, may indicate underlying pathophysiology with, but not limited to, glomerular involvement (e.g., diabetes; 37 ). Taken together with α1-AGP urinalysis being more sensitive than albumin urinalysis (refer to Urinalysis ), it is reasonable to conclude that α1-AGP urinalyses will afford identification of subclinical changes in glomerular responses, translating to earlier disease detection or improved status monitoring.…”
Section: Discussionsupporting
confidence: 73%
“…Similarly, further investigation of this anomaly will be important for understanding physiological excretion levels postexercise. Further, this observation supports the possibility that postexercise α1-AGP excretion, like albumin, may indicate underlying pathophysiology with, but not limited to, glomerular involvement (e.g., diabetes; 37 ). Taken together with α1-AGP urinalysis being more sensitive than albumin urinalysis (refer to Urinalysis ), it is reasonable to conclude that α1-AGP urinalyses will afford identification of subclinical changes in glomerular responses, translating to earlier disease detection or improved status monitoring.…”
Section: Discussionsupporting
confidence: 73%