Exercise-induced alterations in natural killer cell number and function

Moyna, Niall M.; Acker, Gwendolyn R.; Weber, K.; Fulton, Jonathan R.; Robertson, Robert J.; Goss, Fredric L.; Rabin, Bruce S.

doi:10.1007/bf00377445

Cited by 35 publications

(45 citation statements)

References 25 publications

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“…The T-helper cell counts did not decline below resting values, which is in contrast to intense endurance protocols (Kajiura et al, 1995;Moyna et al, 1996). A negative correlation was observed between cortisol concentration and the increase in T-helper cell counts between baseline and 2 h of recovery.…”

Section: Discussioncontrasting

confidence: 71%

Acute impact of submaximal resistance exercise on immunological and hormonal parameters in young men

Ramel

Wagner

Elmadfa

2003

Journal of Sports Sciences

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In this study, we examined the acute effects of submaximal resistance exercise on immunological and hormonal parameters in 7 resistance-trained and 10 non-resistance-trained males. The participants, who were aged 29.5 +/- 7.1 years (mean +/- s), performed submaximal resistance exercise at 75% of their one-repetition maximum. Blood samples were taken before, during, immediately after, and 30, 60 and 120 min after exercise and analysed for leukocyte subpopulations and stress hormones. Total leukocytes, neutrophils and monocytes increased during exercise, reaching their maximum 2 h after exercise. Lymphocytes increased during exercise, T-helper cells returned to resting values after exercise, and natural killer cells and T-suppressor cells decreased below resting values. The CD4/CD8 ratio decreased during exercise but increased during recovery. The resistance-trained participants tended to have lower T-helper cell counts before, during and immediately after exercise and a lower CD4/CD8 ratio during recovery than the non-resistance-trained participants. Plasma cortisol correlated positively with leukocytes during exercise (r = 0.572, P < 0.05), but negatively with T-helper cells 30 and 60 min after exercise (r = -0.573, P < 0.05; r = -0.642, P < 0.01, respectively). Our results indicate that resistance exercise leads to acute changes in leukocyte counts, despite moderate hormonal changes, independent of training status. Regular resistance exercise might lead to decreased T-helper cell counts and a lower CD4/CD8 ratio, which could increase susceptibility to infections.

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Section: Discussioncontrasting

confidence: 71%

Acute impact of submaximal resistance exercise on immunological and hormonal parameters in young men

Ramel

Wagner

Elmadfa

2003

Journal of Sports Sciences

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“…In a series of preliminary studies, we selected the maximal workload that could be completed during the exercise task by the majority of CSCI subjects because both the intensity and duration of the exercise seem to influence the scale of the NK mobilization. Second, earlier studies reported an increase in NKCA and the proportion of NK cells after 6-min cycling exercise at 55% of VO 2 max in AB persons, 20 indicating that short-duration low-intensity exercise can significantly increase NK cell number and activity. Therefore, we expected an increase in NKCA in the selected exercise, which was in fact observed in our AB subjects.…”

Section: Discussionmentioning

confidence: 92%

Impaired immune response to voluntary arm-crank ergometer exercise in patients with cervical spinal cord injury

Yamanaka

Furusawa²,

Sugiyama³

et al. 2010

Spinal Cord

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Study design: Non-randomized study. Objective: The mechanism underlying exercise-induced argumentation of natural killer cell cytotoxic activity (NKCA) in humans remains unclear. To address this, NKCA responses were studied during and after exercise in persons with cervical spinal cord injury (CSCI) and dysfunctional sympathetic nervous system. Setting: Kibikogen Rehabilitation Center for Employment Injuries. Methods: We examined the NKCA responses to 20-min arm-crank ergometer exercise at 60% of maximum oxygen consumption in eight persons with CSCI (between C6 and C7) and six able-bodied subjects. NKCA, adrenaline, and cortisol were measured before, immediately after exercise, 1 h after exercise, and 2 h after exercise. Results: In able-bodied subjects, NKCA increased immediately after exercise (Po0.01) and then decreased to below the pre-exercise level 1 h after exercise, before recovering to the baseline level at 2 h after exercise. Plasma adrenaline concentrations increased significantly immediately after exercise (Po0.01) and returned to the baseline level 1 h after exercise. The plasma cortisol level did not change throughout the study. In contrast, NKCA, plasma concentrations of adrenaline, and cortisol did not change throughout the study in subjects with CSCI. Conclusion: In subjects with CSCI, the lack of response in NKCA throughout the experiment is probably mainly due to a dysfunctional sympathetic nervous system.

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“…We considered that the number of NK cells in peripheral blood that had been mobilized from the lymphatic system during exercise was equal to the number of NK cells moved to damaged tissue from peripheral blood in SCI subjects. Moyna et al 20 reported that since NK cells from the spleen and bone marrow during exercise were immature, their cytotoxic activity must be lower than that of circulating NK. Therefore, 2-h arm ergometer exercise in SCI subjects reduced NKCA although the number of NK cells did not decrease after exercise.…”

Section: Discussionmentioning

confidence: 99%

Attenuation of natural killer cell activity during 2-h exercise in individuals with spinal cord injuries

Ueta

Furusawa²,

Takahashi

et al. 2007

Spinal Cord

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Design: Non-randomized study. Objective: To determine natural killer cell cytotoxic activity (NKCA) to 2-h arm ergometer exercise in persons with spinal cord injuries (SCI) and the underlying mechanism of such response. Setting: University of Occupational and Environmental Health, Japan. Methods: We examined NKCA response to 2-h arm crank ergometer exercise at 60% of maximum oxygen consumption (VO 2max ) in SCI and able-bodied persons. NKCA and plasma concentrations of prostaglandin E 2 (PGE 2 ), adrenaline and cortisol were measured before, during and immediately after the exercise. The study included seven subjects with SCI between Th11 and L4 and six able-bodied persons.Results: NKCA in able-bodied subjects increased (Po0.05) at 60 min of exercise and immediately after the exercise, and remained elevated up to 2 h after exercise. However, NKCA in SCI decreased (Po0.05) immediately after exercise but recovered at 2 h after exercise. Plasma adrenaline in both groups increased significantly (Po0.05) immediately after exercise and returned to baseline level 2 h after the exercise. Plasma cortisol in both groups remained constant throughout the study. In SCI, PGE 2 significantly increased immediately after 2 h exercise and returned to the baseline level 2 h after exercise; however, it remained unchanged during the test in able-bodied subjects. Conclusion: Our results suggested that increase of PGE 2 in SCI partially contributes to NKCA.

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Exercise-induced alterations in natural killer cell number and function

Cited by 35 publications

References 25 publications

Acute impact of submaximal resistance exercise on immunological and hormonal parameters in young men

Acute impact of submaximal resistance exercise on immunological and hormonal parameters in young men

Impaired immune response to voluntary arm-crank ergometer exercise in patients with cervical spinal cord injury

Attenuation of natural killer cell activity during 2-h exercise in individuals with spinal cord injuries

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