Exercise-induced alterations in plasma concentrations of ghrelin, adiponectin, leptin, glucose, insulin, and cortisol in horses

Gordon, M. E.; McKeever, Kenneth H.; Betros, Cynthia L.; Filho, Hélio Cordeiro Manso

doi:10.1016/j.tvjl.2006.01.003

Cited by 77 publications

(70 citation statements)

References 50 publications

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“…An increase of leptin value was indicated 180 min after 5 min of lunging only in mares selected for high leptin concentration (Cartmill et al, 2003). In the study of Gordon et al (2007b), short-term high-intensity exercise did not lead to changes in the leptin level during the first 60 min after the test, but the decrease was shown in this hormone plasma concentration 24 h later. Piccione et al (2004) did not observe any changes in the plasma leptin concentration in exercised athletic horses.…”

Section: Discussionmentioning

confidence: 91%

“…The trend of reported changes was associated with the age of investigated horses. In the paper of Gordon et al (2007b), exercise-induced alternations in plasma concentration of ghrelin were seen only many hours after the short-term, high-intensity exercise in old mares. But during interval exercise tests, the increase in plasma ghrelin concentration was shown just after the end of the effort .…”

Section: Discussionmentioning

confidence: 98%

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Plasma concentration of leptin and ghrelin in Standardbred foals as related to the age, sex, exercise and training

Kędzierski¹,

Kapica²

2008

Animal

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The effect of acute exercise was studied in a group of 42 clinically healthy young Standardbred trotters. These trotters had been divided into four groups according to their age. Their ages were from 1.5 to 3 years. Three jugular venous blood samples were collected via venipuncture from each horse. These samples were collected while (1) at rest, (2) after the end of the exercise and (3) 30 min after the end of the exercise. Exercise showed a significant increase in plasma leptin concentration (3.8 6 0.31 at rest v. 4.3 6 0.37 just after exercise and 4.4 6 0.47 ng/ml after a 30-min rest; ANOVA P , 0.05). The difference between values obtained 30 min after exercise and at rest was significantly greater in 1.5-year-old horses than in those aged 2.5 years (11.3 6 0.43 v. 10.1 6 0.15 ng/ml; ANOVA P , 0.05). The mean plasma leptin concentration was higher in fillies than in colts (4.9 6 0.47 v. 3.5 6 0.36 ng/ml; ANOVA P , 0.05). A positive correlation between the plasma concentrations of leptin and triacylglycerides measured just after exercise was detected (r 5 0.65). The acute exercise significantly increased the plasma concentration of ghrelin that was measured just after exercise (1255 6 55.9 v. 1127 6 54.2 pg/ml; ANOVA P , 0.05). The exercise-induced age-related changes in the plasma ghrelin concentration were significantly lower in 2.5-year-old trotters than in 1.5-year olds. To sum up, the changes in plasma leptin and ghrelin concentrations during bouts of exertion tend to decrease with age and/or training of Standardbred foals.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 98%

Plasma concentration of leptin and ghrelin in Standardbred foals as related to the age, sex, exercise and training

Kędzierski¹,

Kapica²

2008

Animal

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“…Cartmill et al (2003) and Piccione et al (2004) did not find any change in the leptin level of exercised horses. Gordon et al (2007b) only noted a decrease in the plasma leptin concentration 24 h after Standardbred mares had been exercised. Gordon et al (2006) and , however, have reported an increase in plasma leptin concentration observed just after Standardbred horses had been exercised.…”

Section: Discussionmentioning

confidence: 92%

“…Corticosteroids and catecholamine secretions increase during exercise, whereas insulin level decreases. The ratio of changes in these hormones levels depends, however, on the intensity and duration of the performed exercise (Snow et al, 1992;Desmecht et al, 1996;Gordon et al, 2007b). In exercised horses, all variations (increase, decrease or any change) in plasma leptin values have been described (Gordon et al, 2006 and2007b;.…”

Section: Introductionmentioning

confidence: 99%

Changes in plasma leptin concentration during different types of exercises performed by horses

Kędzierski

2014

Animal

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Leptin is a tissue-derivative adipokine that regulates appetite, food intake and energy expenditure. It is still not clear how exercise affects plasma leptin concentration in horses. The aim of this study was to evaluate the influence of exercise intensity and duration on plasma leptin levels in working horses. A total of 38 horses were prospectively included in the study and grouped according to the type of exercise they performed: dressage (six stallions, group D), jumping (12 stallions, group J), race (12 Thoroughbred horses, six stallions and six mares, group R) and harness (10 light draft stallions, group H). Blood samples were taken both before and after routine exercise (immediately after the exercise, 30 min and 24 h after). Blood lactic acid (LA) and plasma concentration of leptin, cortisol, uric acid, triacylglycerols, glycerol and free fatty acids were determined. Immediately after exercise, group R had the highest level of LA, whereas groups D and J had the lowest levels. A significant increase in plasma leptin concentration was stated only in group H in samples taken immediately after the end of the exercise period and 30 min after the exercise period, as compared with the values obtained at rest. A significant increase in plasma cortisol concentration was found immediately after the end of the exercise period in groups R and H. Leptin exercise-to-rest ratio was significantly correlated with cortisol exercise-to-rest ratio (r = 0.64; P < 0.001). The increase in plasma leptin concentration in exercised horses was related to the increased plasma cortisol concentration and took place only during long-lasting exercise, which was not intensive.Keywords: cortisol, leptin, horse, exercise ImplicationsLeptin is an adipokine that regulates energetic metabolism, appetite and food intake in mammals. The effect of exercise on plasma leptin concentration in horses is still not clear. The results of the present study indicate that some kinds of exercise increase the plasma leptin level in horses. Better understanding of the regulation of leptin release during exercise could contribute towards improving the performance and state of health of exercising horses; it is thus clear that detailed knowledge of improving the performance of trained horses will have an economic importance. The data presented in this study have never been published elsewhere.

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“…Outro hormônio liberado com a atividade física é o cortisol em resposta a elevação de ACTH, com pico circulatório cinco a 30 minutos após o término do exercício (Gordon et al 2007). Segundo Hyyppä (2005), sua principal função é prover a biodisponibilidade dos precursores energéticos necessários para manter os esforços musculares através de diversas vias de ação, dentre as quais degradação de proteínas teciduais para liberação de aminoácidos usados na gliconeogênese hepática, mobilização de ácidos graxos livres do tecido adiposo e redução da taxa de utilização celular de glicose.…”

Section: Introductionunclassified

Glicemia e concentrações séricas de insulina, triglicérides e cortisol em equinos da raça Mangalarga Marchador após exercício físico

Coelho

Gama²,

Lopes³

et al. 2011

Pesq. Vet. Bras.

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O presente estudo teve por objetivo avaliar a influência do exercício físico de intensidade submáxima (provas de marcha) sobre as variáveis bioquímicas sanguíneas usadas na avaliação do metabolismo energético em equinos da raça Mangalarga Marchador criados no Estado do Espírito Santo. Para tal foram obtidas amostras de soro e plasma de 15 equinos, da raça Mangalarga Marchador, em quatro momentos assim definidos: antes (T0) e com 5 minutos (T1), 30 minutos (T2) e 2 horas (T3) após o término do exercício. A análise dos resultados demonstrou a não influência do exercício físico imposto sobre a glicose plasmática, com valores médios de 117,1±35,8mg/dL, 122,6±59,6mg/dL, 124,8± 48,6mg/dL e 112,9±49,1mg/dL, e sobre a insulina sérica, com valores de mediana de 6,50mUI/mL, 2,00mUI/mL, 5,85mUI/mL e 11,60mUI/mL, respectivamente, nos tempos T0, T1, T2 e T3. De forma oposta, foi possível observar uma influência significativa sobre triglicérides séricos, com valores médios de 25,4±14,9mg/dL, 42,3±17,8mg/dL, 31,4±17,7mg/dL e 25,1±15,1mg/dL, e sobre o cortisol sérico, com valores médios de 7,46±4,37mg/dL, 12,45±3,08mg/dL, 11,40±2,52mg/dL e 6,89±1,78mg/dL, respectivamente nos tempos T0, T1, T2 e T3. A interpretação destes resultados permitiu concluir que a marcha elevou as concentrações séricas de triglicérides e cortisol. Também foi possível destacar que, por tais valores encontrarem-se dentro de intervalos fisiológicos, os equinos usados estavam aptos ao nível de exercício físico imposto na ocasião.

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Exercise-induced alterations in plasma concentrations of ghrelin, adiponectin, leptin, glucose, insulin, and cortisol in horses

Cited by 77 publications

References 50 publications

Plasma concentration of leptin and ghrelin in Standardbred foals as related to the age, sex, exercise and training

Plasma concentration of leptin and ghrelin in Standardbred foals as related to the age, sex, exercise and training

Changes in plasma leptin concentration during different types of exercises performed by horses

Glicemia e concentrações séricas de insulina, triglicérides e cortisol em equinos da raça Mangalarga Marchador após exercício físico

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