Exercise-induced anaphylaxis: causes, consequences, and management recommendations

Christensen, Morten Junker; Eller, Esben; Kjær, Henrik Fomsgaard; Broesby‐Olsen, Sigurd; Mørtz, Charlotte G.; Bindslev‐Jensen, Carsten

doi:10.1080/1744666x.2019.1562904

Cited by 35 publications

(27 citation statements)

References 82 publications

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“…In severe cases, luminal microbial products are capable of transversion into the systemic circulation, a response now considered to underlie multiple common athletic health conditions (Costa, Snipe, Kitic, & Gibson, ). Specifically, the most concerning of these health conditions include exercise‐induced anaphylaxis (Christensen et al, ) and exertional heatstroke (Lim, ). In nonexercise settings, research has linked GI microbial translocation (MT) within the pathophysiology of numerous chronic diseases, including GI disease (Camilleri, Madsen, Spiller, Meerveld, & Verne, ), cardiovascular disease (Neves, Coelho, Couto, Leite‐Moreira, & Roncon‐Albuquerque, ), and degenerative disorders of the central nervous system (Mulak & Bonaz, ).…”

Section: Introductionmentioning

confidence: 99%

Reliability of gastrointestinal barrier integrity and microbial translocation biomarkers at rest and following exertional heat stress

Ogden

Fallowfield²,

Child

et al. 2020

Physiol Rep

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Purpose Exertional heat stress adversely distrupts (GI) barrier integrity and, through subsequent microbial translocation (MT), negativly impacts health. Despite widespread application, the temporal reliability of popular GI barrier integity and MT biomarkers is poorly characterised. Method Fourteen males completed two 80‐min exertional heat stress tests (EHST) separated by 7–14 days. Venous blood was drawn pre, immediately‐ and 1‐hr post both EHSTs. GI barrier integrity was assessed using the serum Dual‐Sugar Absorption Test (DSAT), Intestinal Fatty‐Acid‐Binding Protein (I‐FABP) and Claudin‐3 (CLDN‐3). MT was assessed using plasma Lipopolysaccharide Binding Protein (LBP), total 16S bacterial DNA and Bacteroides DNA. Results No GI barrier integrity or MT biomarker, except absolute Bacteroides DNA, displayed systematic trial order bias (p ≥ .05). I‐FABP (trial 1 = Δ 0.834 ± 0.445 ng ml−1; trial 2 = Δ 0.776 ± 0.489 ng ml−1) and CLDN‐3 (trial 1 = Δ 0.317 ± 0.586 ng ml−1; trial 2 = Δ 0.371 ± 0.508 ng ml−1) were increased post‐EHST (p ≤ .01). All MT biomarkers were unchanged post‐EHST. Coefficient of variation and typical error of measurement post‐EHST were: 11.5% and 0.004 (ratio) for the DSAT 90‐min postprobe ingestion; 12.2% and 0.004 (ratio) at 150‐min postprobe ingestion; 12.1% and 0.376 ng ml−1 for I‐FABP; 4.9% and 0.342 ng ml−1 for CLDN‐3; 9.2% and 0.420 µg ml−1 for LBP; 9.5% and 0.15 pg µl−1 for total 16S DNA; and 54.7% and 0.032 for Bacteroides/total 16S DNA ratio. Conclusion Each GI barrier integrity and MT translocation biomarker, except Bacteroides/total 16S ratio, had acceptable reliability at rest and postexertional heat stress.

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Section: Introductionmentioning

confidence: 99%

Reliability of gastrointestinal barrier integrity and microbial translocation biomarkers at rest and following exertional heat stress

Ogden

Fallowfield²,

Child

et al. 2020

Physiol Rep

View full text Add to dashboard Cite

show abstract

“…These responses may underpin several potentially serious health conditions that affect physically active populations (e.g. military personnel, firefighters, athletes), including: exercise-induced anaphylaxis (Christensen et al, 2019), central-fatigue (Vargas and Marino, 2016) and exertional heatstroke (Lim, 2018).…”

Section: Introductionmentioning

confidence: 99%

Influence of aerobic fitness on gastrointestinal barrier integrity and microbial translocation following a fixed-intensity military exertional heat stress test

Ogden

Fallowfield²,

Child

et al. 2020

Eur J Appl Physiol

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“…Exercise-induced anaphylaxis is a rare and unpredictable syndrome encountered in athletes but also in those only undertaking small amounts of recreational or submaximal physical activity 95. It most often occurs in association with the ingestion of a food allergen around the time of exercise (but can be up to a few hours later), when it is referred to as food-dependent exercise-induced anaphylaxis.…”

Section: Section 4: Athlete-specific Considerations In Common Respira...mentioning

confidence: 99%

BTS clinical statement for the assessment and management of respiratory problems in athletic individuals

Hull

Burns

Carre

et al. 2022

Thorax

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Exercise-induced anaphylaxis: causes, consequences, and management recommendations

Cited by 35 publications

References 82 publications

Reliability of gastrointestinal barrier integrity and microbial translocation biomarkers at rest and following exertional heat stress

Reliability of gastrointestinal barrier integrity and microbial translocation biomarkers at rest and following exertional heat stress

Influence of aerobic fitness on gastrointestinal barrier integrity and microbial translocation following a fixed-intensity military exertional heat stress test

BTS clinical statement for the assessment and management of respiratory problems in athletic individuals

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