Exercise-induced BDNF production by mononuclear cells of sedentary and physically active obese men

Elsner, Viviane Rostirola; Dorneles, Gilson Pires; Santos, Maeli Andressa; Silva, Igor M. da; Romão, Pedro R T; Peres, Alessandra

doi:10.23736/s0022-4707.19.10113-2

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…For example, a cross-sectional study published in 2011 found that athletes had higher endogenous antioxidant protection than sedentary individuals and the potential mechanism might be that chronic exercise could protect against exercise-induced oxidative stress by upregulating endogenous antioxidant defense systems ( El Abed et al, 2011 ). At the same time, a study published in 2020, whose participants were obese men, identified that exercise can change the redox state and enhance the brain-derived neurotrophic factor production by lipopolysaccharide-stimulated oxidative stress markers of peripheral blood mononuclear cells in obese individuals ( Elsner et al, 2020 ). These physiological and biochemical mechanisms might partially explain the findings of this systematic review that if an elderly individual had daily life without any exercise, the cellular lipid peroxidation in his or her body would be enhanced more.…”

Section: Discussionmentioning

confidence: 99%

Effect of exercise and antioxidant supplementation on cellular lipid peroxidation in elderly individuals: Systematic review and network meta-analysis

et al. 2023

Front. Physiol.

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Background: The viewpoints of previous studies on the correlation between exercise and cellular lipid peroxidation are contradictory from many perspectives and lack evidence for elder individuals. A new systematic review with network meta-analysis is necessary and will have significant practical value to provide high-quality evidence in the development of exercise protocols and an evidence-based guide for antioxidant supplementation for the elderly.Aims: To identify the cellular lipid peroxidation induced by different types of exercise, with or without antioxidant supplementation, in elderly individuals.Methods: Randomized controlled trials that recruited elderly participants and reported cellular lipid peroxidation indicators and were published in peer-reviewed journals in English were searched by a Boolean logic search strategy and screened in the databases PubMed, Medline, Embase, and Web of Science. The outcome measures were the biomarkers of oxidative stress in cell lipids in urine and blood, namely F2-isoprostanes, hydrogen peroxide (LOOH, PEROX, or LIPOX), malondialdehyde (MDA), and thiobarbituric acid reactive substances (TBARS).Result: 7 trials were included. A combination program of aerobic exercise (AE), low-intensity resistance training (LIRT), and a placebo intake (Placebo) and a combination program of aerobic exercise, low-intensity resistance training, and antioxidant supplementation (S) had the most and sub-most potential to dampen cellular lipid peroxidation (AE + LIRT + Placebo: 0.31 in Rank 1 and 0.2 in Rank 2; AE + LIRT + S: 0.19 in Rank 1 and 0.20 in Rank 2); A placebo intake (Placebo) and a blank intervention without exercise (NE) had the most and sub-most potential to induce an enhancement of cellular lipid peroxidation (Placebo: 0.51 in Rank 9 and 0.16 in Rank 8; NE: 0.16 in Rank 9 and 0.28 in Rank 8). All included studies had an unclear risk of selecting reporting. There were no high confidence ratings in all the direct and indirect comparisons, 4 comparisons in the direct evidence structure and 7 comparisons in the indirect evidence structure had moderate confidence.Conclusion: A combined protocol consisting of aerobic exercise and low-intensity resistance training is recommended to dampen cellular lipid peroxidation. Extra antioxidant supplementation might be unnecessary if an elderly individual has enough aerobic and resistance exercise.Systematic Review Registration: CRD42022367430

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Section: Discussionmentioning

confidence: 99%

Effect of exercise and antioxidant supplementation on cellular lipid peroxidation in elderly individuals: Systematic review and network meta-analysis

et al. 2023

Front. Physiol.

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“…However, most of these studies focused on BDNF signalling in the hippocampus [ 83 , 84 , 85 , 86 , 87 ]. It is widely reported that voluntary running results in an increase in the BDNF expression in the hippocampus, cerebral cortex, and other areas of the brain [ 88 ], as well as the protein level of BDNF in the sera of physically active humans [ 89 , 90 , 91 ]. In previous studies, it has been established that a long-term exposure to exercise reverses chronic stress-induced memory deficits via the BDNF induction [ 92 ], and molecular mechanisms regulating this plasticity may include the SIRT1/microRNA, CREB/BDNF, and AKT/GSK-3β signalling pathways [ 93 ].…”

Section: Discussionmentioning

confidence: 99%

Running from Stress: Neurobiological Mechanisms of Exercise-Induced Stress Resilience

Nowacka-Chmielewska¹,

Grabowska

Grabowski

et al. 2022

IJMS

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Chronic stress, even stress of a moderate intensity related to daily life, is widely acknowledged to be a predisposing or precipitating factor in neuropsychiatric diseases. There is a clear relationship between disturbances induced by stressful stimuli, especially long-lasting stimuli, and cognitive deficits in rodent models of affective disorders. Regular physical activity has a positive effect on the central nervous system (CNS) functions, contributes to an improvement in mood and of cognitive abilities (including memory and learning), and is correlated with an increase in the expression of the neurotrophic factors and markers of synaptic plasticity as well as a reduction in the inflammatory factors. Studies published so far show that the energy challenge caused by physical exercise can affect the CNS by improving cellular bioenergetics, stimulating the processes responsible for the removal of damaged organelles and molecules, and attenuating inflammation processes. Regular physical activity brings another important benefit: increased stress robustness. The evidence from animal studies is that a sedentary lifestyle is associated with stress vulnerability, whereas a physically active lifestyle is associated with stress resilience. Here, we have performed a comprehensive PubMed Search Strategy for accomplishing an exhaustive literature review. In this review, we discuss the findings from experimental studies on the molecular and neurobiological mechanisms underlying the impact of exercise on brain resilience. A thorough understanding of the mechanisms underlying the neuroprotective potential of preconditioning exercise and of the role of exercise in stress resilience, among other things, may open further options for prevention and therapy in the treatment of CNS diseases.

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“…Moreover, there have been cases in which higher levels of BDNF were observed in obese people [76]. Elsner et al studied LPS-treated peripheral blood mononuclear cells (PBMC) from obese individuals who performed exercise and from an obese sedentary group and found that the physically active obese patients had increased levels of BDNF and SOD activity compared to their sedentary counterparts [147]. The many hypotheses and contradictory results do not currently allow a clear definition of the role of BDNF in the development of metabolic disorders and obesity.…”

Section: Bdnfmentioning

confidence: 99%

The Role of Adipokines and Myokines in the Pathogenesis of Different Obesity Phenotypes—New Perspectives

Pelczyńska,

Miller-Kasprzak,

Piątkowski

et al. 2023

Antioxidants

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Obesity is a characteristic disease of the twenty-first century that is affecting an increasing percentage of society. Obesity expresses itself in different phenotypes: normal-weight obesity (NWO), metabolically obese normal-weight (MONW), metabolically healthy obesity (MHO), and metabolically unhealthy obesity (MUO). A range of pathophysiological mechanisms underlie the occurrence of obesity, including inflammation, oxidative stress, adipokine secretion, and other processes related to the pathophysiology of adipose tissue (AT). Body mass index (BMI) is the key indicator in the diagnosis of obesity; however, in the case of the NWO and MONW phenotypes, the metabolic disturbances are present despite BMI being within the normal range. On the other hand, MHO subjects with elevated BMI values do not present metabolic abnormalities. The MUO phenotype involves both a high BMI value and an abnormal metabolic profile. In this regard, attention has been focused on the variety of molecules produced by AT and their role in the development of obesity. Nesfatin-1, neuregulin 4, myonectin, irisin, and brain-derived neurotrophic factor (BDNF) all seem to have protective effects against obesity. The primary mechanism underlying the action of nesfatin-1 involves an increase in insulin sensitivity and reduced food intake. Neuregulin 4 sup-presses lipogenesis, decreases lipid accumulation, and reduces chronic low-grade inflammation. Myonectin lowers the amount of fatty acids in the bloodstream by increasing their absorption in the liver and AT. Irisin stimulates the browning of white adipose tissue (WAT) and consequently in-creases energy expenditure, additionally regulating glucose metabolism. Another molecule, BDNF, has anorexigenic effects. Decorin protects against the development of hyperglycemia, but may also contribute to proinflammatory processes. Similar effects are shown in the case of visfatin and chemerin, which may predispose to obesity. Visfatin increases adipogenesis, causes cholesterol accumulation in macrophages, and contributes to the development of glucose intolerance. Chemerin induces angiogenesis, which promotes the expansion of AT. This review aims to discuss the role of adipokines and myokines in the pathogenesis of the different obesity phenotypes.

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Exercise-induced BDNF production by mononuclear cells of sedentary and physically active obese men

Cited by 3 publications

References 33 publications

Effect of exercise and antioxidant supplementation on cellular lipid peroxidation in elderly individuals: Systematic review and network meta-analysis

Effect of exercise and antioxidant supplementation on cellular lipid peroxidation in elderly individuals: Systematic review and network meta-analysis

Running from Stress: Neurobiological Mechanisms of Exercise-Induced Stress Resilience

The Role of Adipokines and Myokines in the Pathogenesis of Different Obesity Phenotypes—New Perspectives

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