Exercise-induced, but not creatine-induced, decrease in intramyocellular lipid content improves insulin sensitivity in rats

Vaisy, Morad; Szlufcik, Karolina; Bock, Katrien De; Eijnde, Bert O.; Proeyen, Karen Van; Verbeke, Kristin; Veldhoven, Paul Van; Hespel, Peter

doi:10.1016/j.jnutbio.2010.10.004

Cited by 14 publications

(20 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study, OLM and OOM did not differ for body fat and IMCL, but the exercise treatment decreased IMCL significantly only in the OOM group. The decrement of IMCL following exercise intervention is in line with a previous study in rats [46], but some studies in humans reported increments in IMCL after aerobic exercise [47,48]. In a study of elderly men, aerobic but not resistance exercise increased IMCL [49].…”

Section: Discussionsupporting

confidence: 89%

Resistance training improves skeletal muscle insulin sensitivity in elderly offspring of overweight and obese mothers

et al. 2015

View full text Add to dashboard Cite

Aims/hypothesis Maternal obesity predisposes offspring to adulthood morbidities, including type 2 diabetes. Type 2 diabetes and insulin resistance have been associated with shortened telomere length. First, we aimed to investigate whether or not maternal obesity influences insulin sensitivity and its relationship with leucocyte telomere length (LTL) in elderly women. Second, we tested whether or not resistance exercise training improves insulin sensitivity in elderly frail women. Methods Forty-six elderly women, of whom 20 were frail offspring of lean/normal weight mothers (OLM, BMI ≤26.3 kg/m 2 ) and 17 were frail offspring of overweight/ obese mothers (OOM, BMI ≥28.1 kg/m 2 ), were studied before and after a 4 month resistance training (RT) intervention. Muscle insulin sensitivity of glucose uptake was measured using 18 F-fluoro-2-deoxyglucose and positron emission tomography with computed tomography during a hyperinsulinaemic-euglycaemic clamp. Muscle mass and lipid content were measured using magnetic resonance and LTL was measured using real-time PCR. Results The OOM group had lower thigh muscle insulin sensitivity compared with the OLM group (p=0.048) but similar whole body insulin sensitivity. RT improved whole body and skeletal muscle insulin sensitivity in the OOM group only (p=0.004 and p=0.013, respectively), and increased muscle mass in both groups (p<0.01). In addition, in the OOM group, LTL correlated with different thigh muscle groups insulin sensitivity (ρ ≥ 0.53; p ≤ 0.05). Individuals with shorter LTL showed a higher increase in skeletal muscle insulin sensitivity after training (ρ≥−0.61; p≤0.05). Conclusions/interpretation Maternal obesity and having telomere shortening were associated with insulin resistance in adult offspring. A resistance exercise training programme may reverse this disadvantage among offspring of obese mothers. Trial registration: ClinicalTrials.gov NCT01931540Electronic supplementary material The online version of this article

show abstract

Section: Discussionsupporting

confidence: 89%

Resistance training improves skeletal muscle insulin sensitivity in elderly offspring of overweight and obese mothers

et al. 2015

View full text Add to dashboard Cite

show abstract

“…One study did not mention the sample size . Six studies were controlled (Ferrante et al 2000;Eijnde et al 2001;Ju et al 2005;Souza et al 2006;Op't Eijnde et al 2006;Araújo et al 2013), and 5 were randomized and controlled (Young and Young 2002;Rooney et al 2002;Freire et al 2008;Vaisy et al 2011;Nicastro et al 2012). The median sample size was 63 animals (ranging from 8 to 72).…”

Section: Animal Studiesmentioning

confidence: 99%

“…Only Ferrante et al (2000) studied mice; the other studies used rats (Rooney et al 2002;Young and Young 2002;Ju et al 2005;Souza et al 2006;Op't Eijnde et al 2006;Freire et al 2008;Vaisy et al 2011;Eijnde et al 2001;Nicastro et al 2012;Araújo et al 2013). Eight studies investigated healthy animals (Young and Young 2002;Rooney et al 2002;Ju et al 2005;Souza et al 2006;Freire et al 2008;Eijnde et al 2001;Vaisy et al 2011;Araújo et al 2013), Ferrante et al (2000 used a transgenic mouse model of Huntington's Disease, Op't Eijnde et al (2006) studied Goto-Kakizaki rats (a animal model of inherited T2DM), and Nicastro et al (2012) used rats treated with dexamethasone. Four studies examined the effects of creatine supplementation associated with exercise training on glucose metabolism (Souza et al 2006;Freire et al 2008;Vaisy et al 2011;Araújo et al 2013), and seven studies The search strategy consists of two separate components and each component consists of the key words related to "creatine supplementation" and the key words related to "glucose metabolism" individually.…”

Section: Animal Studiesmentioning

confidence: 99%

“…Eight studies investigated healthy animals (Young and Young 2002;Rooney et al 2002;Ju et al 2005;Souza et al 2006;Freire et al 2008;Eijnde et al 2001;Vaisy et al 2011;Araújo et al 2013), Ferrante et al (2000 used a transgenic mouse model of Huntington's Disease, Op't Eijnde et al (2006) studied Goto-Kakizaki rats (a animal model of inherited T2DM), and Nicastro et al (2012) used rats treated with dexamethasone. Four studies examined the effects of creatine supplementation associated with exercise training on glucose metabolism (Souza et al 2006;Freire et al 2008;Vaisy et al 2011;Araújo et al 2013), and seven studies The search strategy consists of two separate components and each component consists of the key words related to "creatine supplementation" and the key words related to "glucose metabolism" individually. The key words in each component were linked using "OR" as a Boolean function, and the results of the two sections were combined by utilizing the "AND" Boolean in final search adopted creatine supplementation alone (Young and Young 2002;Rooney et al 2002;Ju et al 2005;Souza et al 2006;Op't Eijnde et al 2006;Eijnde et al 2001;Nicastro et al 2012).…”

Section: Animal Studiesmentioning

confidence: 99%

“…The key words in each component were linked using "OR" as a Boolean function, and the results of the two sections were combined by utilizing the "AND" Boolean in final search adopted creatine supplementation alone (Young and Young 2002;Rooney et al 2002;Ju et al 2005;Souza et al 2006;Op't Eijnde et al 2006;Eijnde et al 2001;Nicastro et al 2012). Studies that involved exercise training employed swimming (Souza et al 2006;Freire et al 2008;Vaisy et al 2011) or treadmill running (Araújo et al 2013). The dose of creatine supplementation was described as the percentage of the amount of supplement in the diet (from 1 to 13 %) or as the daily dose (ranging from 300 to 5 g/ kg).…”

Section: Animal Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Creatine supplementation and glycemic control: a systematic review

et al. 2016

View full text Add to dashboard Cite

The focus of this review is the effects of creatine supplementation with or without exercise on glucose metabolism. A comprehensive examination of the past 16 years of study within the field provided a distillation of key data. Both in animal and human studies, creatine supplementation together with exercise training demonstrated greater beneficial effects on glucose metabolism; creatine supplementation itself demonstrated positive results in only a few of the studies. In the animal studies, the effects of creatine supplementation on glucose metabolism were even more distinct, and caution is needed in extrapolating these data to different species, especially to humans. Regarding human studies, considering the samples characteristics, the findings cannot be extrapolated to patients who have poorer glycemic control, are older, are on a different pharmacological treatment (e.g., exogenous insulin therapy) or are physically inactive. Thus, creatine supplementation is a possible nutritional therapy adjuvant with hypoglycemic effects, particularly when used in conjunction with exercise.

show abstract

Western diet given to healthy rats mimics the human phenotype of diabetic cardiomyopathy

Verboven

Deluyker

Ferferieva

et al. 2018

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

Exercise-induced, but not creatine-induced, decrease in intramyocellular lipid content improves insulin sensitivity in rats

Cited by 14 publications

References 60 publications

Resistance training improves skeletal muscle insulin sensitivity in elderly offspring of overweight and obese mothers

Resistance training improves skeletal muscle insulin sensitivity in elderly offspring of overweight and obese mothers

Creatine supplementation and glycemic control: a systematic review

Western diet given to healthy rats mimics the human phenotype of diabetic cardiomyopathy

Contact Info

Product

Resources

About