“…As previously described, most cases of reported exercise induced CAVB are infranodal [10,11,17], though there are also reports describing a supranodal block [8], suggesting the utility of EPS to ascertain the specific site in question [8,10,13]. One possible explanation for exercise induced CAVB, as previously described [10,11,13], derives from the differences in the conduction properties and refractory periods between the AV node (with increased conduction and decreased refractory period associated with exercise) and the His-Purkinje system (not under autonomic control, and as such whose refractory period is not substantially altered by exercise). Contrary to the physiologic response elicited in a normal conduction system, in the presence of conduction tissue disease (such as the case presented, given the baseline ECG characteristics) the diseased His-Purkinje system could thus be unable to conduct the impulses form the rapidly conducting AV node, and as such lead to a CAVB [10,11,13].…”