Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs

Scheffer, Débora da Luz; Latini, Alexandra

doi:10.1016/j.bbadis.2020.165823

Cited by 254 publications

(196 citation statements)

References 206 publications

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“…Im Rahmen von präventiven Maßnahmen sind z. B. immunmodulierende und antiinflammatorische Effekte einer gesunden Lebensweise bereits früh im Pandemiegeschehen diskutiert worden [ 44 , 45 ]. Bisher liegen aber noch keine epidemiologischen Daten oder Interventionsstudien vor, die den Zusammenhang zwischen Ernährung, Bewegungsverhalten und COVID-19 untersuchten.…”

Section: Prävention Und Therapieempfehlungen Für Covid-19unclassified

Herz-Kreislauf-Erkrankungen und COVID-19

Schieffer

Hilfiker‐Kleiner

2021

Herz

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ZusammenfassungCOVID-19 („coronavirus disease 2019“) ist eine Herausforderung für unser Gesundheitssystem und gleichzeitig eine der herausragenden Katalysatoren erfolgreicher translationaler Forschung. COVID-19 ist nicht nur eine simple Viruserkrankung des Bronchialsystems, sondern eine pandemisch auftretende, hyperinflammatorische Multiorganerkrankung. Das Herz-Kreislauf-System spielt dabei eine kausale Rolle, da SARS-CoV‑2 („severe acute respiratory syndrome coronavirus 2“) Wirtszellen über ACE(„angiotensin-converting enzyme“)-2, ein Enzym des Renin-Angiotensin-Systems, befällt. Darüber hinaus spielen kardiovaskuläre Komorbiditäten und Risikofaktoren wie Bluthochdruck, Diabetes und Adipositas eine wichtige Rolle für die Schwere der Krankheitsverläufe. Zusätzliche Risikofaktoren wie Geschlecht, Alter, Genetik und Luftverschmutzung modulieren sowohl die Schwere der SARS-CoV-2-Infektion als auch kardiovaskuläre Erkrankungen. Als Folge von COVID-19 kommt es zu vermehrten Thrombosen, Herzinfarkten, Herzmuskelentzündungen und Vaskulitiden, die das kardiovaskuläre System direkt schädigen und wesentlich zur Morbidität und Mortalität beitragen. Erkenntnisse aus zahlreichen Studien zu Krankheitsverläufen von SARS-CoV-2-infizierten Patienten haben zu besseren Therapiemöglichkeiten geführt, die nun in der zweiten Welle zum Teil standardisiert und insbesondere auch an Komplikationen des kardiovaskulären Systems angepasst wurden und werden. In diesem Review geben wir einen kurzen Überblick über die Pathophysiologie des SARS-CoV-2-Virus allgemein sowie auch spezifisch auf das kardiovaskuläre System. Daraus folgend, fassen wir die aktuellen Therapieansätze und deren pathophysiologische Grundlagen (Stand November 2020) zusammen.

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Section: Prävention Und Therapieempfehlungen Für Covid-19unclassified

Herz-Kreislauf-Erkrankungen und COVID-19

Schieffer

Hilfiker‐Kleiner

2021

Herz

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“…Araujo et al [ 16 ] suggested that physical training induces adaptations to the stress mediated by an immune response, resulting by changes in the cytokine profile. However, pro-inflammatory cytokines (including IL-6, TNF-alpha and IL-17AA) may be preferentially upregulated during acute exercise, while chronically prolonged physical activity may promote an anti-inflammatory status presumably associated with IL-10 secretion [ 3 , 4 , 14 , 17 , 18 , 19 ]. Furthermore, Heisterberg et al [ 20 ] have shown that variations of haemoglobin and haematocrit were related to the amount of aerobic and anaerobic training, strength training and the number of matches per week in professional soccer players.…”

Section: Introductionmentioning

confidence: 99%

Can Haematological and Hormonal Biomarkers Predict Fitness Parameters in Youth Soccer Players? A Pilot Study

Perroni

Migliaccio

Borrione

et al. 2020

IJERPH

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The study aimed to investigate the correlations among immune, haematological, endocrinological markers and fitness parameters, and assess if the physiological parameters could be a predictor of fitness values. Anthropometric, physical evaluations (countermovement jump—CMJ, 10 m sprint, VO2max, repeated sprint ability—RSA total time and index) and determination of blood (IL-6, IL-10, IL-17A and tumour necrosis factor) and salivary (testosterone and cortisol) samples parameters in 28 young male soccer players (age: 13.0 ± 0.2 years, body mass index (BMI): 19.5 ± 2.2 kg/m2) were analysed. To evaluate the dependence of the variables related to athletic performance, multiple linear regression with backward stepwise elimination was considered. A significant regression equation was found in CMJ (F(5,16) = 9.86, p < 0.001, R2 adjusted = 0.679) and in the RSA index (F(5,16) = 15.39, p < 0.001, R2 adjusted = 0.774) considering only five variables, in a 10 m sprint (F(4,17) = 20.25, p < 0.001, R2 adjusted = 0.786) and in the RSA total time (F(4,17) = 15.31, p < 0.001, R2 adjusted = 0.732) considering only four variables and in VO2max (F(9,12) = 32.09, p < 0.001, R2 adjusted = 0.930) considering nine variables. Our study suggests the use of regression equations to predict the fitness values of youth soccer players by blood and saliva samples, during different phases of the season, short periods of match congestion or recovery from an injury.

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“…Studies have shown that exercise is closely related to the immune ability of the body. [ 7 ] Regular exercise can significantly improve the immune ability of the body and reduce the incidence of infectious diseases, [ 8 ] while long-term high-intensity exercise or lack of exercise is an important cause of immune decline. [ 9 , 10 ] Bernardi and Simpson found that regular moderate intensity training can significantly improve the immune ability of the body and effectively reduce the incidence of respiratory diseases.…”

Section: Introductionmentioning

confidence: 99%

The effects of exercise on COVID-19 therapeutics

Chen

et al. 2020

Medicine

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Background: At the end of 2019, peoples normal lives were disrupted by a sudden plague (COVID-19), the huge impact of COVID-19 on society has never been appeared. How to effectively prevent and treat COVID-19 is a concern for all health care workers. Exercise as a green and cheap complementary therapy, which has been proven to improve the immune capacity of the body and prevent infection. The main purpose of this study is to provide a reliable methodological guidance and credible evidence for exercise on COVID-19 therapeutic. Methods: This protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. We will search the following database sources for the Randomized controlled trials: the Cochrane Library, PubMed, EMBASE, Web of Science, Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure Database (CNKI), Chinese Science and the Wanfang Database. All randomized controlled trials of exercise therapy for COVID-19 in the above database will be considered for inclusion, and high-quality articles will be screened for data extraction and analysis, to summarize the therapeutic effect of exercise on COVID-19 patients. Results: In this study, we hope to find strong evidence for the treatment of COVID-19 by exercise. Conclusion: The conclusion of our study will provide credible evidence to judge whether exercise is an effective intervention on the COVID-19 patients therapeutic, and guide future researches. PROSPERO registration number: CRD42020200883.

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Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs

Cited by 254 publications

References 206 publications

Herz-Kreislauf-Erkrankungen und COVID-19

Herz-Kreislauf-Erkrankungen und COVID-19

Can Haematological and Hormonal Biomarkers Predict Fitness Parameters in Youth Soccer Players? A Pilot Study

The effects of exercise on COVID-19 therapeutics

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