Exercise-Induced NT-pro BNP Secretion in Hypertensive Patients Without Heart Failure Can Diagnose the Subclinical Left Ventricle Dysfunction

Paun, Nicolae; Sinelli, Ingrid Joanna; Nicolae, Camelia; Nanea, Ioan Tiberiu; Toader, Corneliu

doi:10.2478/inmed-2021-0164

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…In the other two groups analyzed separately, there was no statistical signi cance. Alteration of left ventricular diastolic function and heart failure with preserved ejection fraction have been described in diabetic patients in the general population and hospitalized diabetic patients alike (7). The same abnormalities exist in many other diseases, such as hypertension, left ventricle hypertrophy, stenotic valvular diseases, and coronary disease.…”

Section: Resultsmentioning

confidence: 92%

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Exercise-induced secretion of NT-pro BNP in asymptomatic hypertensive patients with type 2 diabetes mellitus – an early sign of subclinical ventricular dysfunction

Paun

Busnatu

Jinga

et al. 2023

Preprint

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Background: The association between hypertension (HTN) and type 2 diabetes mellitus (DM) frequently leads to left ventricular diastolic dysfunction (DD). Methods: We aim to test whether DD can readily be unveiled as early as in the subclinical stage in diabetic hypertensive asymptomatic patients, even before echocardiography can do so. We compared the values of NT-pro BNP (as a marker of increased filling pressures) before and after the treadmill stress test in hypertensive patients with and without diabetes mellitus (DM) and normal subjects. All had normal systolic and diastolic functions at rest and after the stress test, according to the recommendations of the ESC. Results: The results from our study showed a significant increase inNT-pro BNP after the stress test, but only in hypertensive patients with diabetes. Conclusion: Compared with echocardiography, measuring the changes inNT-pro BNP after the stress test in hypertensive and diabetic patients with class A heart failure could be a tool for diagnosing DD much earlier in the evolution of the disease. This is an important finding because these patients are difficult to distinguish from those with normal left ventricle function, based only on restingNT-pro BNP or echocardiography. In this way, they can benefit much earlier from specific therapies to mitigate future cardiovascular events.

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Section: Resultsmentioning

confidence: 92%

“…The association between exercise and the release of NP (BNP and NT pro-BNP) has already been proven in patients with and without cardiovascular diseases [5][6]. Moreover, elevated NT-pro BNP levels were identi ed postexercise in hypertensive patients with left ventricular hypertrophy [7].…”

Section: Introductionmentioning

confidence: 99%

Exercise-induced secretion of NT-pro BNP in asymptomatic hypertensive patients with type 2 diabetes mellitus – an early sign of subclinical ventricular dysfunction

Paun

Busnatu

Jinga

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

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NT-pro BNP versus E/E’ Ratio after ECG Treadmill Test in Asymptomatic Hypertensive Patients with Exercise-Induced Diastolic Dysfunction

Paun

Uscoiu

Hodorogea

et al. 2021

Romanian Journal of Cardiology

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Left ventricle dysfunction is the link between the heart morphological changes and the overt heart failure. Hypertension is one of the main cardio-vascular conditions which can lead to development of left ventricle failure. The study was conducted at outpatient Clinic – Medlife, Memorial Hospital. It intended to compare NT-pro BNP and the ratio E/E’ as markers of diastolic dysfunction in hypertensive patients and normal ejection fraction (EF) and no signs or symptoms of heart failure. Both indexes proved to refl ect independently diastolic dysfunction in symptomatic patients with different cardiac diseases but not in asymptomatic hypertensive patients. It was a singlecenter observational study recruiting 40 participants (20 F 52-70 age, and 20 M 56-67 age). Natriuretic peptides are widely accepted as biomarkers in heart failure with reduced ejection fraction. NT-pro BNP proved to be a very good means of diagnosing exercise-related left ventricular dysfunction (LVD) showing that it could unveil a subclinical LVD, especially in patient with myocardial remodeling. The main goal of this study was to compare the values of NT-pro BNP and E/E’. We have found no correlation between NT-pro BNP and E/E’, both pre-exercise and post-exercise, demonstrating that the later was not a reliable means of diagnosing LVD at effort in aymptomatic hypertensive patients.

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Exercise-Induced NT-pro BNP Secretion in Hypertensive Patients Without Heart Failure Can Diagnose the Subclinical Left Ventricle Dysfunction

Cited by 2 publications

References 19 publications

Exercise-induced secretion of NT-pro BNP in asymptomatic hypertensive patients with type 2 diabetes mellitus – an early sign of subclinical ventricular dysfunction

Exercise-induced secretion of NT-pro BNP in asymptomatic hypertensive patients with type 2 diabetes mellitus – an early sign of subclinical ventricular dysfunction

NT-pro BNP versus E/E’ Ratio after ECG Treadmill Test in Asymptomatic Hypertensive Patients with Exercise-Induced Diastolic Dysfunction

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