Exercise-Induced Proteinuria

Campanacci, L; Faccini, L; Englaro, Emanuela; Rustia, R; Guarnieri, Gabriele; Barat, R.; Carraro, Michele; Zotti, R De; Micheli, W

doi:10.1159/000396102

Cited by 15 publications

(7 citation statements)

References 23 publications

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“…Urinary protein creatinine ratios measuring protein by routine chemical methods have also been used but have not been widely adopted.18-20 It has probably been assumed that the protein content of a single urine sample could not accurately reflect total daily urinary excretion of protein because this fluctuates considerably during a 24 hour period, being reduced by recumbency or a high urine flow21 and increased by exercise. 22 We found the protein creatinine index on random specimens to be very sensitive: all patients excreting more than 150 mg protein a day had an index for random samples of more than 127. The index on early morning specimens was less sensitive and 15% of patients had results less than 108.…”

Section: Albustix Studiesmentioning

confidence: 81%

Protein creatinine index and Albustix in assessment of proteinuria.

Shaw¹,

Risdon²,

Lewis-Jackson³

1983

BMJ

139

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The protein creatinine index in early morning and random urine specimens was compared with the 24 hour urinary excretion of protein in normal subjects and outpatients with abnormal proteinuria. A protein creatinine index (defined as (mg protein/l divided by creatinine mmol/l) times 10) below 125 in a random specimen excluded abnormal proteinuria, whereas an index of more than 136 indicated the presence of pathological proteinuria. The index for random specimens provided a useful semiquantitative assessment of the 24 hour excretion of protein (mg protein/24 hours), but the index for early morning specimens was less reliable. Errors with Albustix were partly due to intra and inter observer variations in the interpretation of the colour formed when compared with the chart provided.It is proposed that the protein creatinine index on random urine samples should be used to supplement dipsticks in screening for proteinuria in cases where misclassification would be serious. IntroductionMinor degrees of proteinuria may indicate the presence of

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Section: Albustix Studiesmentioning

confidence: 81%

Protein creatinine index and Albustix in assessment of proteinuria.

Shaw¹,

Risdon²,

Lewis-Jackson³

1983

BMJ

139

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“…Huttunen" and Campanacci et al 26 failed to find any increase in 11 2 -microglobulin excretion after exercise and Leiper et al 27 did not observe any change in NAG excretion during low intensity walks. On the other hand excretion of 11 2 -rnicroglobulin,'!…”

Section: Discussionmentioning

confidence: 93%

Protein Excretion after Prolonged Exercise

Robertshaw

Cheung

Fairly³

et al. 1993

Ann Clin Biochem

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SUMMARY. Random urine samples were obtained from 16 healthy subjects (nine men and seven women) before and after a 100 KIn hill walk for the estimation of total protein, albumin, N-acetyl-{j-glucosaminidase (NAG), retinol binding protein (RBP) and creatinine. The excretion of total protein, albumin and NAG (expressed in relation to creatinine excretion) increased significantly after the walk. The relative clearance of protein and albumin also increased. In four subjects serial measurements were made for 4 days and the excretion of albumin and NAG on the fourth day were similar to the pre-walk values. We conclude that proteinuria of prolonged exercise is at least partly due to reduced tubular reabsorption.

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“…These studies have demonstrated that moderate physical activity induces an apparent abnormality in glomemlar permeability, manifest as an increase in the urinary excretion of albumin and other high molecular weight proteins (9,39). On the other hand, strenuous, exhaustive exercise appears to increase the urinary excretion of both albumin and lysozyme or B2-microglobulin, thus demonstrating both a "glomerular" and "tubular" pattern (9-1 1, 39).…”

Section: Discussionmentioning

confidence: 99%

Characterization of Recumbent, Ambulatory, and Postexercise Proteinuria in the Adolescent

Houser

1987

Pediatr Res

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ABSTRACT. To better characterize the effects of body position and exercise on urinary protein excretion, carefully defined random urine samples were obtained during recumbency and following both ambulation and exercise in healthy adolescent student athletes. Albumin, lysozyme, and N-acetyl-B-D-glucosaminidase were measured in all samples. Glomerular permeability and tubular function were assessed using the urinary albumin creatinine ratio (UAlb/UCr), the urinary lysozyme creatinine ratio ( U L~/ U~) , the urinary N-acetyl-B-D-glucosaminidase creatinine ratio (UNa$Ucr), and the urinary lysozyme albumin ratio (Uty/ UAtb). UAlb/UCr was significantly ( p < 0.001) lower In recumbent urine samples than in either ambulatory or postexercise samples, although no difference was seen between the latter two groups. Furthermore, recumbent UAlb/UCr was higher in females ( p < 0.01) and postexercise UAlb/UCr varied significantly ( p < 0.001), depending on the type of physical activity. ULy/Uc, UN~$UC=, and ULy/UAlb were unaffected by either posture or physical activity. A significant correlation was found between UAlb/UCr and UNa$Ucr ( r = 0.60, p = 0.0001) and also between U L~/ U C~ and ULy/UAlb (r = 0.84, p = 0.001). In addition, urinespecific gravity was found to have a significant negative correlation with UAlb/Ucr ( r = -0.33, p = 0.001). The results of this study suggest that in the adolescent, recumbent albumin excretion is higher in females and that ambulation increases glomerular permeability. Exercise does not appear to induce any additional alteration in glomerular permeability, although the effects of exercise are likelyrelated to the type and severity of physical activity. Renal tubular function is unaltered by either ambulation or exercise. Furthermore, urinary albumin excretion may be increased in the face of diuresis and urinary N-acetyl-B-Dglucosaminidase excretion may be stimulated by the effects of increasing albumin excretion. (Pediatr Res 21: 442-446, 1987) Abbreviations ULy/Uc, urinary lysozyme creatinine ratio UAlb/Ucr, urinary albumin creatinine ratio UNa$Ua, urinary N-acetyl-B-D-glucosaminidase creatinine ratio ULy/UAlb urinary lysozyme albumin ratio ANOVA, analysis of variance NAG, N-acetyl-B-D-glucosaminidase 4-MU, 4-methylumbelliferone SAS, statistical analysis system

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Exercise-Induced Proteinuria

Cited by 15 publications

References 23 publications

Protein creatinine index and Albustix in assessment of proteinuria.

Protein creatinine index and Albustix in assessment of proteinuria.

Protein Excretion after Prolonged Exercise

Characterization of Recumbent, Ambulatory, and Postexercise Proteinuria in the Adolescent

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