Exercise-induced recovery of plasma lipids perturbed by ageing with nanoflow UHPLC-ESI-MS/MS

Kim, Kang Uk; Yoon, Kyeong Jin; Park, Soo Hong; Lee, Mi Kyung; Moon, Hyo Youl; Moon, Myeong Hee

doi:10.1007/s00216-020-02933-w

Cited by 8 publications

(5 citation statements)

References 48 publications

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“…In the present study, exercise training reduced several ceramide and sphingomyelin species, and dihydrosphingomyelins. This finding is consistent with previous research showing that exercise reduced plasma ceramide (c14:0) in obese and diabetic subjects ( 89 ) and in mice ( 90 ). Exercise training also decreased sphingosines and sphingolipid synthesis metabolites.…”

Section: Discussionsupporting

confidence: 93%

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease

et al. 2021

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Increasing evidence indicates that physical activity and exercise training may delay or prevent the onset of Alzheimer’s disease (AD). However, systemic biomarkers that can measure exercise effects on brain function and that link to relevant metabolic responses are lacking. To begin to address this issue, we utilized blood samples of 23 asymptomatic late middle-aged adults, with familial and genetic risk for AD (mean age 65 years old, 50% female) who underwent 26 weeks of supervised treadmill training. Systemic biomarkers implicated in learning and memory, including the myokine Cathepsin B (CTSB), brain-derived neurotrophic factor (BDNF), and klotho, as well as metabolomics were evaluated. Here we show that aerobic exercise training increases plasma CTSB and that changes in CTSB, but not BDNF or klotho, correlate with cognitive performance. BDNF levels decreased with exercise training. Klotho levels were unchanged by training, but closely associated with change in VO2peak. Metabolomic analysis revealed increased levels of polyunsaturated free fatty acids (PUFAs), reductions in ceramides, sphingo- and phospholipids, as well as changes in gut microbiome metabolites and redox homeostasis, with exercise. Multiple metabolites (~30%) correlated with changes in BDNF, but not CSTB or klotho. The positive association between CTSB and cognition, and the modulation of lipid metabolites implicated in dementia, support the beneficial effects of exercise training on brain function. Overall, our analyses indicate metabolic regulation of exercise-induced plasma BDNF changes and provide evidence that CTSB is a marker of cognitive changes in late middle-aged adults at risk for dementia.

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Section: Discussionsupporting

confidence: 93%

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease

et al. 2021

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“…Moderate CR can be used to halt the age- related kidney dysfunction by inhibiting the endothelin-1 (ET-1) expression [68]. In aged mice, physical exercise reduces triacylglycerol and restores plasma lipids homeostasis by regulating lipid metabolism [70]. Dehydroascorbic acid (DHA) retards or even reverses renal impairment in mouse models of ageing [71].…”

Section: Therapeutic Strategies For Kidney Ageingmentioning

confidence: 99%

“…Senolytics Dasatinib and quercetin [78], fisetin [79], catechins [80], uPAR-targeted CAR-T [58 && ], ABT263 [55], A1331852 [81], A1155463 [81], ABT737 [81], alvespimycin (17-DMAG) [76], FOXO4-DRI [56], panobinostat [82], BPTES [61 & ] Senostatics SS31 [83], klotho [62], mitoQ [84], SKQ1 [85], melatonin [86], ICG001 [45], Na 2 S 4 [43], ganoderma lucidum [87], ruxolitinib [75], MSC-derived EVs [64], SIRT1 activator [65], PPAR-g agonists [66], metformin [67], rapamycin [88] Nutrient regulators Calorie restriction [69,89], exercise [70], resveratrol [90], curcumin [91], spermidine [92], barbarum [93], DHA [71] DHA, dehydroascorbic acid; MSC, mesenchymal stem cells; PPAR-g, peroxisome proliferator-activated receptor-g; uPAR, urokinase-type plasminogen activator receptor.…”

Section: Senotherapy Agentsmentioning

confidence: 99%

Ageing, cellular senescence and chronic kidney disease: experimental evidence

Tan

Liu

2022

Current Opinion in Nephrology &Amp; Hypertension

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Purpose of reviewChronic kidney disease (CKD) is often viewed as an accelerated and premature ageing of the kidney, as they share common pathological features characterized by cellular senescence. In this review, we summarize the experimental evidence linking cellular senescence to the pathobiology of kidney ageing and CKD, and discuss the strategies for targeting senescent cells in developing therapeutics for ageing-related kidney disorders. Recent findingsKidney ageing and CKD are featured with increased cellular senescence, an irreversible state of cell cycle arrest and the cessation of cell division. Senescent cells secrete a diverse array of proinflammatory and profibrotic factors known as senescence-associated secretory phenotype (SASP). Secondary senescence can be induced by primary senescent cells via a mechanism involving direct contact or the SASP. Various senolytic therapies aiming to selectively remove senescent cells in vivo have been developed. Senostatic approaches to suppress senescence or inhibit SASP, as well as nutrient signalling regulators are also validated in animal models of ageing.

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“…Nevertheless, IMT decreased the serum levels of saturated lysophospholipid [LysoPC (16:0/0:0)] and lysophosphatidylethanolamine [LysoPE (18:0/0:0)]. Studies have shown that the serum elevation of these saturated fatty acids is associated with low-grade inflammation as a result of the aging process and metabolic disorders like insulin resistance, type 2 diabetes, and stroke [33][34][35]. In addition, Sphingosine 1-phosphate also decreased after IMT.…”

Section: Discussionmentioning

confidence: 99%

Insights into the Serum Metabolic Adaptations in Response to Inspiratory Muscle Training: A Metabolomic Approach Based on 1H NMR and UHPLC-HRMS/MS

Castro,

Catai,

Rehder-Santos

et al. 2023

IJMS

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Inspiratory muscle training (IMT) is known to promote physiological benefits and improve physical performance in endurance sports activities. However, the metabolic adaptations promoted by different IMT prescribing strategies remain unclear. In this work, a longitudinal, randomized, double-blind, sham-controlled, parallel trial was performed to investigate the effects of 11 weeks (3 days·week−1) of IMT at different exercise intensities on the serum metabolomics profile and its main regulated metabolic pathways. Twenty-eight healthy male recreational cyclists (30.4 ± 6.5 years) were randomized into three groups: sham (6 cm·H2O of inspiratory pressure, n = 7), moderate-intensity (MI group, 60% maximal inspiratory pressure (MIP), n = 11) and high-intensity (HI group, 85–90% MIP, n = 10). Blood serum samples were collected before and after 11 weeks of IMT and analyzed by 1H NMR and UHPLC-HRMS/MS. Data were analyzed using linear mixed models and metabolite set enrichment analysis. The 1H NMR and UHPLC-HRMS/MS techniques resulted in 46 and 200 compounds, respectively. These results showed that ketone body metabolism, fatty acid biosynthesis, and aminoacyl-tRNA biosynthesis were upregulated after IMT, while alpha linolenic acid and linoleic acid metabolism as well as biosynthesis of unsaturated fatty acids were downregulated. The MI group presented higher MIP, Tryptophan, and Valine levels but decreased 2-Hydroxybutyrate levels when compared to the other two studied groups. These results suggest an increase in the oxidative metabolic processes after IMT at different intensities with additional evidence for the upregulation of essential amino acid metabolism in the MI group accompanied by greater improvement in respiratory muscle strength.

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Exercise-induced recovery of plasma lipids perturbed by ageing with nanoflow UHPLC-ESI-MS/MS

Cited by 8 publications

References 48 publications

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease

Ageing, cellular senescence and chronic kidney disease: experimental evidence

Insights into the Serum Metabolic Adaptations in Response to Inspiratory Muscle Training: A Metabolomic Approach Based on 1H NMR and UHPLC-HRMS/MS

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