Exercise, Inflammation, and Innate Immunity

Woods, Jeffrey A.; Vieira, Victoria J.; Keylock, K. Todd

doi:10.1016/j.ncl.2006.03.008

Cited by 111 publications

(92 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, both of these interventions have been shown to reduce a variety of inflammatory markers in longitudinal studies (Forsythe et al, 2008;Woods et al, 2009). More recent research using measures of body composition have suggested that the amount of weight loss during exercise is the most significant factor in reducing inflammation, whereas other studies using BMI concluded that the effects of exercise are independent of weight reduction (Woods et al, 2009; ............................................................................................................................................................. al, 2011). Nevertheless, the relationship among weight loss or exercise, inflammation, and depression or anxiety is only beginning to be established.…”

Section: Reviewmentioning

confidence: 99%

Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation

Miller

Haroon

Felger

2016

Neuropsychopharmacol

118

124

View full text Add to dashboard Cite

A wealth of data has been amassed that details a complex, yet accessible, series of pathways by which the immune system, notably inflammation, can influence the brain and behavior. These data have opened the window to a diverse array of novel targets whose potential efficacy is tied to specific neurotransmitters and neurocircuits as well as specific behaviors. What is clear is that the impact of inflammation on the brain cuts across psychiatric disorders and engages dopaminergic and glutamatergic pathways that regulate motivation and motor activity as well as the sensitivity to threat. Given the ability to identify patient populations with increased inflammation, the precision of interventions can be further tuned, in conjunction with the ability to establish target engagement in the brain through the use of multiple neuroimaging strategies. After a brief overview of the mechanisms by which inflammation affects the brain and behavior, this review examines the extant literature on the efficacy of anti-inflammatory treatments, while forging guidelines for future intelligent clinical trial design. An examination of the most promising therapeutic strategies is also provided, along with some of the most exciting clinical trials that are currently being planned or underway.

show abstract

Section: Reviewmentioning

confidence: 99%

Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation

Miller

Haroon

Felger

2016

Neuropsychopharmacol

118

124

View full text Add to dashboard Cite

show abstract

“…There is a breadth of literature examining links between physical activity and inflammation (Andersson et al, 2010;Ertek & Cicero, 2012;Gleeson et al, 2011;Kasapis & Thompson, 2005;Woods et al, 2009). While some have focused on athletes, there are also studies that have focused on average activity in healthy adults.…”

Section: Physical Activity and Inflammationmentioning

confidence: 99%

“…There is a well-established literature regarding the associations between personality and inflammation (Luchetti, Barkley, Stephan, Terracciano, & Sutin, 2014;Sutin et al, 2010;Turiano, Mroczek, Moynihan, & Chapman, 2013), between personality and physical activity (Cotter & Lachman, 2010;De Moor, Beem, Stubbe, Boomsma, & De Geus, 2006;Wilson, Das, Evans, & Dishman, 2015), and between physical activity and chronic inflammation (Ertek & Cicero, 2012;Kasapis & Thompson, 2005;Woods, Vieira, & Keylock, 2009;Woods, Wilund, Martin, & Kistler, 2012). However, none have examined possible interlinking pathways between the three constructs.…”

Section: Introductionmentioning

confidence: 99%

Physical Activity Mediates the Association between Personality and Biomarkers of Health

Graham¹,

Bastarache²,

Milad³

et al. 2017

Preprint

View full text Add to dashboard Cite

The current study investigated whether personality traits and facets predicted levels of Interleukin-6, C-reactive protein, and Fibrinogen and whether physical activity mediated the relationship between personality and these biomarkers of health. High harm avoidance and low neuroticism were associated with elevated IL-6, while high social potency, high control, and low achievement were associated with elevated FGN. Mediation models suggested that physical activity mediated the association between higher levels of achievement and lower IL-6. Physical activity is an important factor in the health behavior model, and explains some of the associations between personality and downstream inflammation.

show abstract

“…It is possible that, as with other diseases, the timing of the initiation of exercise training, type of training, duration and frequency of exercise are important in modifying myeloma risk 49 and that benefits would be observed with controlled training interventions. Exercise also directly modifies the expression of growth factors 50 and inflammatory mediators 51,52 that may be potential therapeutic targets in preventing MGUS to myeloma progression. Yet, there is no conclusive evidence that exercise training without caloric restriction has any appreciable impact on weight loss 53,54 and may even result in weight gain.…”

Section: Epidemiological Evidence Linking Obesity To Mgus Incidence Amentioning

confidence: 99%

The skinny on obesity and plasma cell myeloma: a review of the literature

Carson

Bates

Tomasson

2014

Bone Marrow Transplant

View full text Add to dashboard Cite

Despite tremendous advances in treatments for myeloma in the past decade, the disease remains incurable in the majority of patients. Here, we review recent data demonstrating an association between obesity and increased risk of myeloma development. This may be due to the pro-inflammatory cytokine profile caused by obesity. Currently, there are no screening or prevention strategies for myeloma, but we propose that obesity-associated inflammatory pathways, or obesity itself, may be amenable to intervention, thereby preventing the transition from pre-malignancy to myeloma. In addition, we suggest that the morbidity, mortality and the significant costs associated with myeloma treatment could be reduced by addressing modifiable risk factors, and that research efforts should explore this novel hypothesis. INTRODUCTIONOver the past several decades, the prevalence of obesity has increased markedly in the United States. 1 Today, two-thirds of the adult population in the United States is overweight (defined as body mass index (BMI) = 25 kg/m 2 and o 30 kg/m 2 ) or obese (BMI 30 kg/m 2 ). 2 A BMI greater than 25 kg/m 2 is associated with increased all-cause mortality. 3,4 This increased risk exists even in the absence of typically-measured metabolic abnormalities, suggesting that there is no 'benign phenotype' for obesity. 5 A substantial number of these premature obesity-related deaths is due to cancer. 6,7 Although the common solid tumor malignancies have received much attention, data from case-control and prospectively followed cohort studies have also demonstrated a positive association between obesity and plasma cell myeloma incidence and death. 7,8

show abstract

Exercise, Inflammation, and Innate Immunity

Cited by 111 publications

References 73 publications

Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation

Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation

Physical Activity Mediates the Association between Personality and Biomarkers of Health

The skinny on obesity and plasma cell myeloma: a review of the literature

Contact Info

Product

Resources

About