Exercise Preconditioning Attenuates the Response to Experimental Colitis and Modifies Composition of Gut Microbiota in Wild-Type Mice

Cho, Jinkyung; Kim, Dong-Hyun; Kang, Hyunah

doi:10.3390/life10090200

Cited by 13 publications

(13 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A prebiotics study in overweight and obese children found B. vulgatus was significantly correlated with fat and found to be depleted following the intervention (Nicolucci et al, 2017). Exercise also decreased B. vulgatus in a mouse model of colitis (Cho et al, 2020). This suggests that B. vulgatus is associated with obesity and that a decrease in its prevalence via exercise signifies an improvement in host health, as seems to have also been the case in our study.…”

Section: Discussionsupporting

confidence: 84%

Synergistic effects of exercise and catalase overexpression on gut microbiome

See

Amos

Wright

et al. 2021

Environmental Microbiology

View full text Add to dashboard Cite

Summary Exercise influences metabolic parameters in part by modulating redox stress and as recently suggested, by affecting the gut microbiome. However, whether excess endogenous antioxidant potentiates or interferes with the beneficial effects of exercise on the gut microbiome is not known. A comparison of the gut microbiome of C57Bl6 (C57/WT) mice to the ‘stress‐less’ catalase overexpressing mice models ([Tg(CAT)±] and Bob‐Cat), that were either exercised or remained sedentary, showed differences in both alpha and beta diversity. The significant variation was explained by genotypes along with exercise, suggesting a synergistic relationship between exercise and genotypic traits. Linear discriminant analysis effect size (LEfSe) analysis also revealed differential taxa within the exercised/genotype cohorts in contrast to those within sedentary/genotype cohorts. Functional pathway predictions from PICRUSt2 showed enrichment for the metabolism of short‐chain fatty acids, butanoate and propanoate pathways in exercised groups. Spearman correlations between enriched taxa and metabolic parameters showed correlations with body or fat weight in some of the cohorts. However, there were significant correlations of differential taxa among all cohorts against parameters that predict energy metabolism, such as respiratory exchange ratio and energy expenditure. Overall, our study showed that there was a synergistic beneficial influence of antioxidant overexpression and exercise on the gut microbiome.

show abstract

Section: Discussionsupporting

confidence: 84%

Synergistic effects of exercise and catalase overexpression on gut microbiome

See

Amos

Wright

et al. 2021

Environmental Microbiology

View full text Add to dashboard Cite

show abstract

“…Furthermore, enlarged spleen and increased splenic myeloid and Th17 cells were observed in HFHS-fed mice, whereas they were decreased in MLNs, suggesting that immune cells may be mobilized on the inflammation site, i.e., the colon, similar to what has been observed with HF-induced colonic dysbiosis ( 38 ). It would have been necessary to explore this hypothesis by performing IHC stainings of flow cytometry on colons samples, it is one of the limitations of our study.…”

Section: Discussionsupporting

confidence: 51%

Long-Term Overconsumption of Fat and Sugar Causes a Partially Reversible Pre-inflammatory Bowel Disease State

et al. 2021

View full text Add to dashboard Cite

Nutrition appears to be an important environmental factor involved in the onset of inflammatory bowel diseases (IBD) through yet poorly understood biological mechanisms. Most studies focused on fat content in high caloric diets, while refined sugars represent up to 40% of caloric intake within industrialized countries and contribute to the growing epidemics of inflammatory diseases. Herein we aim to better understand the impact of a high-fat-high-sucrose diet on intestinal homeostasis in healthy conditions and the subsequent colitis risk. We investigated the early events and the potential reversibility of high caloric diet-induced damage in mice before experimental colitis. C57BL/6 mice were fed with a high-fat or high-fat high-sucrose or control diet before experimental colitis. In healthy mice, a high-fat high-sucrose diet induces a pre-IBD state characterized by gut microbiota dysbiosis with a total depletion of bacteria belonging to Barnesiella that is associated with subclinical endoscopic lesions. An overall down-regulation of the colonic transcriptome converged with broadly decreased immune cell populations in the mesenteric lymph nodes leading to the inability to respond to tissue injury. Such in-vivo effects on microbiome and transcriptome were partially restored when returning to normal chow. Long-term consumption of diet enriched in sucrose and fat predisposes mice to colitis. This enhanced risk is preceded by gut microbiota dysbiosis and transcriptional reprogramming of colonic genes related to IBD. Importantly, diet-induced transcriptome and microbiome disturbances are partially reversible after switching back to normal chow with persistent sequelae that may contribute to IBD predisposition in the general population.

show abstract

“…The increased levels of Bacteroides vulgatus, which were observed during COVID-19 infection compared to samples collected three weeks following a negative PCR test, could suggest that the infection could result in subsequent infiltration of acute inflammatory cells through the gut barrier and result in the development of colitis symptoms [49].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Infection Alters the Microbiome: Elite Athletes and Sedentary Patients Have Similar Bacterial Flora

Babszky

Torma

Aczel

et al. 2021

Genes

View full text Add to dashboard Cite

Regular exercise can upgrade the efficiency of the immune system and beneficially alter the composition of the gastro-intestinal microbiome. We tested the hypothesis that active athletes have a more diverse microbiome than sedentary subjects, which could provide better protection against COVID-19 during infection. Twenty active competing athletes (CA) (16 male and 4 females of the national first and second leagues), aged 24.15 ± 4.7 years, and 20 sedentary subjects (SED) (15 male and 5 females), aged 27.75 ± 7.5 years, who had been diagnosed as positive for COVID-19 by a PCR test, served as subjects for the study. Fecal samples collected five to eight days after diagnosis and three weeks after a negative COVID-19 PCR test were used for microbiome analysis. Except for two individuals, all subjects reported very mild and/or mild symptoms of COVID-19 and stayed at home under quarantine. Significant differences were not found in the bacterial flora of trained and untrained subjects. On the other hand, during COVID-19 infection, at the phylum level, the relative abundance of Bacteroidetes was elevated during COVID-19 compared to the level measured three weeks after a negative PCR test (p < 0.05) when all subjects were included in the statistical analysis. Since it is known that Bacteroidetes can suppress toll-like receptor 4 and ACE2-dependent signaling, thus enhancing resistance against pro-inflammatory cytokines, it is suggested that Bacteroidetes provide protection against severe COVID-19 infection. There is no difference in the microbiome bacterial flora of trained and untrained subjects during and after a mild level of COVID-19 infection.

show abstract

Exercise Preconditioning Attenuates the Response to Experimental Colitis and Modifies Composition of Gut Microbiota in Wild-Type Mice

Cited by 13 publications

References 38 publications

Synergistic effects of exercise and catalase overexpression on gut microbiome

Synergistic effects of exercise and catalase overexpression on gut microbiome

Long-Term Overconsumption of Fat and Sugar Causes a Partially Reversible Pre-inflammatory Bowel Disease State

COVID-19 Infection Alters the Microbiome: Elite Athletes and Sedentary Patients Have Similar Bacterial Flora

Contact Info

Product

Resources

About