Exercise regulation of hepatic lipid droplet metabolism

Fuente, Francisco Pino-de la; Bórquez, Juan Carlos; Díaz-Castro, Francisco; Espinosa, Alejandra; Chiong, Mario; Troncoso, Rodrigo

doi:10.1016/j.lfs.2022.120522

Cited by 14 publications

(10 citation statements)

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“…Hepatic lipid accumulation was the typical symptom of the non-alcohol fatty liver disease (NAFLD) ( 22 ), and Ex has been widely recommended to be an effective therapy for the management of NAFLD ( 23 ). However, the recent study indicated that although Ex could increase the energy utilization, the improvement of NAFLD was probably due to the changes in the features of hepatic lipid droplets rather than the decrease of the lipid contents ( 24 ). Therefore, Ex might achieve the hepatoprotective effect without the reduction of the hepatic lipid concentrations.…”

Section: Discussionmentioning

confidence: 99%

Regular exercise combined with ferulic acid exhibits antiobesity effect and regulates metabolic profiles in high-fat diet-induced mice

et al. 2022

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Exercise (Ex) has been recognized as an effective way of obesity prevention, but it shows a dual effect on the body's antioxidant system. Ferulic acid (FA) is a kind of phenolic acid with well-known antioxidant capacity and numerous health benefits. Therefore, the aim of the study was to compare the antiobesity effect of Ex, FA, and Ex combined with FA (Ex-FA) in vivo and to illustrate the potential mechanisms. Mice were fed a high-fat diet (HFD) with or without administration of Ex, FA, and Ex-FA for 13 weeks. The body weight, antioxidant ability, Ex performance, and lipid profiles in the serum, liver, and skeletal muscle were compared among the groups, and serum metabolomics analysis was conducted. The results showed that Ex, FA, and Ex-FA exhibited a similar effect on body weight management. Ex had a more beneficial function by alleviating HFD-induced dyslipidemia than FA, while FA exerted a more efficient effect in mitigating lipid deposition in the liver and skeletal muscle. Ex-FA showed comprehensive effects in the regulation of the lipid contents in serum, liver, and skeletal muscle, and provoked enhancement effects on antioxidant ability and Ex capacity. Mice administered with Ex, FA, and Ex-FA showed different metabolic profiles, which might be achieved through different metabolic pathways. The findings of this research implied that Ex coupled with FA could become an effective and safe remedy for the management of dietary-induced obesity.

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Section: Discussionmentioning

confidence: 99%

Regular exercise combined with ferulic acid exhibits antiobesity effect and regulates metabolic profiles in high-fat diet-induced mice

et al. 2022

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“…De novo synthesis of hepatic fatty acids (termed de novo lipogenesis [DNL]) cannot explain the documented increase in IHL in response to exercise, 45 as fatty acid oxidation (upregulated by exercise) and fatty acid synthesis pathways are reciprocal. Moreover, hepatic very low‐density lipoprotein production does not appear to change after acute exercise 54 …”

Section: The Acute Effect Of Exercise On Total Hepatic Lipid Contentmentioning

confidence: 97%

“…Moreover, hepatic very low-density lipoprotein production does not appear to change after acute exercise. 54…”

Section: The Acute Effect Of Exercise On Total Hepatic Lipid Contentmentioning

confidence: 99%

The effect of acute and chronic exercise on hepatic lipid composition

Willis

Malaikah

Parry

et al. 2023

Scandinavian Med Sci Sports

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Exercise is recommended for those with, or at risk of nonalcoholic fatty liver disease (NAFLD), owing to beneficial effects on hepatic steatosis and cardiometabolic risk. Whilst exercise training reduces total intrahepatic lipid in people with NAFLD, accumulating evidence indicates that exercise may also modulate hepatic lipid composition. This metabolic influence is important as the profile of saturated (SFA), monounsaturated (MUFA), and polyunsaturated fatty acids (PUFA) dramatically affect the metabolic consequences of hepatic lipid accumulation; with SFA being especially lipotoxic. Relatedly, obesity and NAFLD are associated with hepatic PUFA depletion and elevated SFA. This review summarizes the acute (single bout) and chronic (exercise training) effects of exercise on hepatic lipid composition in rodents (acute studies: n = 3, chronic studies: n = 13) and humans (acute studies: n = 1, chronic studies: n = 3). An increased proportion of hepatic PUFA after acute and chronic exercise is the most consistent finding of this review. Mechanistically, this may relate to an enhanced uptake of adipose-derived PUFA (reflecting habitual diet), particularly in rodents.A relative decrease in the proportion of hepatic MUFA after chronic exercise is also documented repeatedly, particularly in rodent models with elevated hepatic MUFA. This outcome is related to decreased hepatic stearoyl-CoA desaturase-1 activity in some studies. Findings regarding hepatic SFA are less consistent and limited by the absence of metabolic challenge in rodent models. These findings

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“…NASH is distinguished from NAFL by the presence of hepatocyte injury (hepatocyte ballooning and cell death), inflammatory infiltrates, and/or collagen deposition (fibrosis) (3). Although several studies show that exercise attenuates the progression of NAFLD (4)(5)(6)(7)(8), the mechanism that explains this is not entirely clear. Some studies show that it is given that exercise decreases liver lipid accumulation (9,10).…”

Section: Introductionmentioning

confidence: 99%

Effects of Aerobic Exercise in Hepatic Lipid Droplet-Mitochondria interaction in Non-alcoholic Fatty Liver Disease

Bórquez

Díaz-Castro

Fuente

et al. 2023

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Lipid Droplets (LD) are highly dynamic storage organelles. In the liver, its accumulation causes non-alcoholic fatty liver (NAFL) that can progress to a more severe disease stage, nonalcoholic steatohepatitis (NASH). In hepatic and non-hepatic tissues LD interacts with mitochondria impacting lipid homeostasis. However, whether exercise modulates this interaction in the liver has not been studied yet. Our objective is to determine whether exercise modifies LD-mitochondria interaction in hepatocytes and if this interaction has an association with the severity of the disease. Two different models of NAFLD, a high fat diet (HFD) to evaluate NAFL and a methionine choline deficient diet (MCD) to evaluate NASH, were used to analyze the effects of aerobic exercise in the liver. Our results in the NAFL model showed that exercise decreased the severity of the disease and improved physical capacity compared to sedentary HFD mice. In this regard, although exercise increased the number of LD in hepatocytes, LD were smaller in size than in the sedentary HFD mice. Notably, while sedentary HFD mice increased hepatic lipid droplet (LD)-mitochondria interaction, in exercised animals, this interaction was decreased. Additionally, exercise decreased the size of the LD bound to mitochondria, and this peridroplet mitochondria (PDM) exhibited higher basal respiration and ATP synthesis capacity than PDM from sedentary HFD mice. Besides, we found a positive correlation that predicts the severity of NAFL between LD-mitochondria interaction in the liver and plasmatic ALT transaminases. This correlation is also positive between hepatic LD-mitochondria interaction and the area under the glucose tolerance test curve in this model. Our results in the NASH model resemble, to a greater extent, what we observed in the NAFL model. In NASH, exercise also reduced collagen accumulation, decreased LD-mitochondria interaction, and reduced the size of LD coupled to mitochondria compared to sedentary MCD mice. In all, our results show that aerobic exercise decreases LD-mitochondria interaction in hepatocytes and this interaction is associated with less severity of NAFL and NASH. We propose that exercise provokes an improvement of NAFLD by reduction of the hepatic LD-mitochondria interaction that in turn increase peridroplet mitochondria activity.

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Exercise regulation of hepatic lipid droplet metabolism

Cited by 14 publications

References 115 publications

Regular exercise combined with ferulic acid exhibits antiobesity effect and regulates metabolic profiles in high-fat diet-induced mice

Regular exercise combined with ferulic acid exhibits antiobesity effect and regulates metabolic profiles in high-fat diet-induced mice

The effect of acute and chronic exercise on hepatic lipid composition

Effects of Aerobic Exercise in Hepatic Lipid Droplet-Mitochondria interaction in Non-alcoholic Fatty Liver Disease

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