Exercise rehabilitation strategy for the prevention of sarcopenia in cancer populations: 8th in a series of scientific evidence

Jee, Yong-Seok

doi:10.12965/jer.2244124.062

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…This can be a practical way to prevent the harmful toxic buildup from cancer treatments. Similar to this context, several previous studies do not seem to disagree that physical activity and/or exercise play an important role in innate immunocyte function [ 17 , 38 , 39 , 45 , 47 ].…”

Section: Discussionsupporting

confidence: 56%

Immunoprotecting Effects of Exercise Program against Ovarian Cancer: A Single-Blind, Randomized Controlled Trial

Lee

Park

Jee

2022

Cancers

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Exercise is known to help the immune function of cancer survivors after cancer cell removal, but there is little information about the effect of exercise on ovarian cancer survivors. We conducted this study to investigate the effects of exercise training on the physical fitness and innate immunity of ovarian cancer survivors (OCS). Twenty-seven OCS between forty-two and sixty-one years of age volunteered for this study. The participants were divided into a control group (COG, n = 15) and an exercise group (EXG, n = 12). The mean (SD) age was 51.07 (5.67) years, and the mean post-operation period was 45.96 (5.88) months. EXG participated in regular exercise training 6 days a week for 12 weeks. Body weight, fat mass, and body mass index of EXE were significantly decreased compared with those of COG. The muscle mass in EXE was increased compared to that of COG. Physical fitness factors showed positive changes in EXG compared to COG. We found that exercise training enhanced lymphocyte and neutrophil counts of leucocytes and total natural killer (NK) and natural killer T (NKT) cell counts of lymphocytes through improved body composition and physical fitness after 12 weeks. Moreover, we found that improved innate immune cells through the exercise program were achieved through an increase in NKG2D+NK receptors and a decrease in KIR2DL3+NK receptors in OCS.

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Section: Discussionsupporting

confidence: 56%

Immunoprotecting Effects of Exercise Program against Ovarian Cancer: A Single-Blind, Randomized Controlled Trial

Lee

Park

Jee

2022

Cancers

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“… 36 Generally, the recommended exercise regimen for inducing hypertrophy in healthy adults consists of 6–12 repetition maximum and 3–6 sets, with a frequency of 2–3 days per week. 37 However, it is uncertain whether this model is suitable for cancer patients. In a meta-analysis of RT intervention in prostate cancer patients, Lopez et al demonstrated that resistance-based exercise programs have significant effects on body and limb lean mass as well as SMI, with even more significant effects in specific subgroups that are younger and have lower baseline physical function.…”

Section: Exercisementioning

confidence: 99%

Non-Pharmacological Strategies for Managing Sarcopenia in Chronic Diseases

Hu,

Wang,

et al. 2024

CIA

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This article focuses on a range of non-pharmacological strategies for managing sarcopenia in chronic diseases, including exercise, dietary supplements, traditional Chinese exercise, intestinal microecology, and rehabilitation therapies for individuals with limited limb movement. By analyzing multiple studies, the article aims to summarize the available evidence to manage sarcopenia in individuals with chronic diseases. The results strongly emphasize the role of resistance training in addressing chronic diseases and secondary sarcopenia. Maintaining the appropriate frequency and intensity of resistance training can help prevent muscle atrophy and effectively reduce inflammation. Although aerobic exercise has limited ability to improve skeletal muscle mass, it does have some positive effects on physical function. Building upon this, the article explores the potential benefits of combined training approaches, highlighting their helpfulness for overall quality of life. Additionally, the article also highlights the importance of dietary supplements in combating muscle atrophy in chronic diseases. It focuses on the importance of protein intake, supplements rich in essential amino acids and omega-3, as well as sufficient vitamin D to prevent muscle atrophy. Combining exercise with dietary supplements appears to be an effective strategy for preventing sarcopenia, although the optimal dosage and type of supplement remain unclear. Furthermore, the article explores the potential benefits of intestinal microecology in sarcopenia. Probiotics, prebiotics, and bacterial products are suggested as new treatment options for sarcopenia. Additionally, emerging therapies such as whole body vibration training, blood flow restriction, and electrical stimulation show promise in treating sarcopenia with limited limb movement. Overall, this article provides valuable insights into non-pharmacological strategies for managing sarcopenia in individuals with chronic diseases. It emphasizes the importance of a holistic and integrated approach that incorporates exercise, nutrition, and multidisciplinary interventions, which have the potential to promote health in the elderly population. Future research should prioritize high-quality randomized controlled trials and utilize wearable devices, smartphone applications, and other advanced surveillance methods to investigate the most effective intervention strategies for sarcopenia associated with different chronic diseases.

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“…Muscle loss due to aging also can reduce the quality of life and shorten the lifespan by reducing the immunocytes function (Hadgraft et al, 2015;Shlisky et al, 2017). Previous studies have reported that sarcopenia is more serious in women than in men as the age increases (Cho et al, 2022;Jee, 2022), and it is also an op-portunity to cause disorders in immunocytes (Ali et al, 2021). The decreased function of immunocyte makes it exposed to various infections, and continuous fatigue and pain increase (Booth et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Moderate- to fast-walking improves immunocytes through a positive change of muscle contractility in old women: a pilot study

Park¹,

Park²,

Jee³

2023

J Exerc Rehabil

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This study aimed to examine whether compared with a program without walking, intervention programs with three types of walking can improve the muscle property and immunocytes in elderly women. Thirty-two subjects were randomly assigned to control group (CON), slow walking group (SWG), moderate walking group (MWG), and fast walking group (FWG). Three types of walking on treadmill were 30 min a day, 5 days/wk for 12 weeks. Muscle contraction time (Tc), maximum displacement (Dm), and immunocytes were tested by tensiomyography and flow cytometry. After the intervention, FWG had an increasing tendency in the muscle mass compared with other three groups. Tc of biceps femoris (BF) decreased in CON and SWG, while Tc of BF in MWG and FWG (30.58%± 23.71%) increased. It was similar in the rectus femoris (RF). Although Dm of BF and RF increased in CON and SWG, those decreased in MWG and FWG. Leucocytes of CON and SWG had a decreasing tendency, those of MWG (9.65%± 13.01%) and FWG (13.01%± 13.58%) increased. In the neutrophil, only CON decreased, whereas the three groups showed an increasing tendency. Helper T cell was increased only in FWG (19.61%± 19.94%), showing significant differences between groups (<i>P</i>= 0.009, <i>η</i>²= 0.378). Natural killer cell was improved in SWG and MWG but showed a clear increase in FWG (75.76%± 63.57%). It might be confirmed that walking for elderly increases the muscle property of the lower legs as they walk faster, which might be expected to improve the immunocytes function.

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Exercise rehabilitation strategy for the prevention of sarcopenia in cancer populations: 8th in a series of scientific evidence

Cited by 5 publications

References 5 publications

Immunoprotecting Effects of Exercise Program against Ovarian Cancer: A Single-Blind, Randomized Controlled Trial

Immunoprotecting Effects of Exercise Program against Ovarian Cancer: A Single-Blind, Randomized Controlled Trial

Non-Pharmacological Strategies for Managing Sarcopenia in Chronic Diseases

Moderate- to fast-walking improves immunocytes through a positive change of muscle contractility in old women: a pilot study

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