Exercise to Improve Postural Stability in Older Adults with Alzheimer’s Disease: A Systematic Review of Randomized Control Trials

Adzhar, Mohamad Asyraf; Manlapaz, Donald; Singh, Devinder Kaur Ajit; Mesbah, Normala

doi:10.3390/ijerph191610350

Cited by 12 publications

(10 citation statements)

References 26 publications

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“…Interventions that target multiple fall risk factors have been more commonly tested in a clinical trial setting with mixed results [ 61 , 67 , 76 , 82 ]. For example, an intervention that included exercise and tailored home hazard removal among community-dwelling older adults with cognitive impairment [ 61 ] and an intervention that included medication review, vision correction, exercise, and home hazard modification in people with cognitive impairment did not reduce falls [ 82 ].…”

Section: Fall Prevention Interventions For Older Adults With Alzheime...mentioning

confidence: 99%

“…For example, an intervention that included exercise and tailored home hazard removal among community-dwelling older adults with cognitive impairment [ 61 ] and an intervention that included medication review, vision correction, exercise, and home hazard modification in people with cognitive impairment did not reduce falls [ 82 ]. However, a recent review of fall prevention interventions found that those targeting strength, balance, and cognition (executive function) can improve postural stability and may reduce the risk of falling among older adults with AD [ 67 ]; however, additional research is needed to examine the effectiveness of multicomponent fall prevention interventions for older adults with AD.…”

Section: Fall Prevention Interventions For Older Adults With Alzheime...mentioning

confidence: 99%

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Falls and Alzheimer Disease

2024

Adv Geriatr Med Res

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Falls are the leading cause of injury, disability, and injury-related mortality in the older adult population. Older adults with Alzheimer disease (AD) are over twice as likely to experience a fall compared to cognitively normal older adults. Intrinsic and extrinsic fall risk factors may influence falls during symptomatic AD; intrinsic factors include changes in cognition and impaired functional mobility, and extrinsic factors include polypharmacy and environmental fall hazards. Despite many known fall risk factors, the high prevalence of falls, and the presence of effective fall prevention interventions for older adults without cognitive impairment, effective fall prevention interventions for older adults with AD to date are limited and inconclusive. Falls may precede AD-related cognitive impairment during the preclinical phase of AD, though a narrow understanding of fall risk factors and fall prevention interventions for older adults with preclinical AD limits clinical treatment of falls among cognitively normal older adults with preclinical AD. This mini review explores fall risk factors in symptomatic AD, evidence for effective fall prevention interventions in symptomatic AD, and preclinical AD as an avenue for future falls research, including recommendations for future research directions to improve our understanding of falls and fall risk during preclinical AD. Early detection and tailored interventions to address these functional changes are needed to reduce the risk of falls for those at risk for developing AD. Concerted efforts should be dedicated to understanding falls to inform precision fall prevention strategies for this population.

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Section: Fall Prevention Interventions For Older Adults With Alzheime...mentioning

confidence: 99%

Section: Fall Prevention Interventions For Older Adults With Alzheime...mentioning

confidence: 99%

Falls and Alzheimer Disease

2024

Adv Geriatr Med Res

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“…In order to enhance functional capacity and prevent falls in older adults (65 years and older), it is recommended to incorporate in the lifestyle a diverse multicomponent physical activity on three or more days a week that emphasizes functional balance and strength training at moderate or greater intensity [ 284 ]. A recent review suggests that combined muscle strength, balance and motor function training can improve postural stability in older adults with AD and reduce cases of falls [ 285 ]. However, this type of training does not seem to be different for elderly people without AD.…”

Section: Individual Approachesmentioning

confidence: 99%

Interdisciplinary Approaches to Deal with Alzheimer’s Disease—From Bench to Bedside: What Feasible Options Do Already Exist Today?

Ablinger¹,

Dressel

Rott³

et al. 2022

Biomedicines

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Alzheimer’s disease is one of the most common neurodegenerative diseases in the western population. The incidence of this disease increases with age. Rising life expectancy and the resulting increase in the ratio of elderly in the population are likely to exacerbate socioeconomic problems. Alzheimer’s disease is a multifactorial disease. In addition to amyloidogenic processing leading to plaques, and tau pathology, but also other molecular causes such as oxidative stress or inflammation play a crucial role. We summarize the molecular mechanisms leading to Alzheimer’s disease and which potential interventions are known to interfere with these mechanisms, focusing on nutritional approaches and physical activity but also the beneficial effects of cognition-oriented treatments with a focus on language and communication. Interestingly, recent findings also suggest a causal link between oral conditions, such as periodontitis or edentulism, and Alzheimer’s disease, raising the question of whether dental intervention in Alzheimer’s patients can be beneficial as well. Unfortunately, all previous single-domain interventions have been shown to have limited benefit to patients. However, the latest studies indicate that combining these efforts into multidomain approaches may have increased preventive or therapeutic potential. Therefore, as another emphasis in this review, we provide an overview of current literature dealing with studies combining the above-mentioned approaches and discuss potential advantages compared to monotherapies. Considering current literature and intervention options, we also propose a multidomain interdisciplinary approach for the treatment of Alzheimer’s disease patients that synergistically links the individual approaches. In conclusion, this review highlights the need to combine different approaches in an interdisciplinary manner, to address the future challenges of Alzheimer’s disease.

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“…Physical activity now forms a key part of many clinical recommendations for the management of dementia [ 3 , 4 ]. Physical activity interventions improve fitness, balance, and mobility [ 5 ], reduce feelings of distress, and may decrease fall risk [ 6 , 7 ]. Physical activity participation may also reduce cognitive decline among persons with dementia [ 8 , 9 ], though not all studies agree [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Dementia resources for eating, activity, and meaningful inclusion (DREAM) toolkit co-development: process, output, and lessons learned

Middleton,

Freeman,

Pelletier

et al. 2023

Res Involv Engagem

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Promoting wellbeing of persons with dementia and their families is a priority of research and practice. Engaging diverse partners, including persons with dementia and their families, to co-develop interventions promotes relevant and impactful solutions. We describe the process, output, and lessons learned from the dementia resources for eating, activity, and meaningful inclusion (DREAM) project, which co-developed tools/resources with persons with dementia, care partners, community service providers, health care professionals, and researchers with the aim of increasing supports for physical activity, healthy eating, and wellbeing of persons with dementia. Our process included: (1) Engaging and maintaining the DREAM Steering Team; (2) Setting and navigating ways of engagement; (3) Selecting the priority audience and content; (4) Drafting the toolkit; (5) Iterative co-development of tools and resources; (6) Usability testing; and (7) Implementation and evaluation. In virtual meetings, the DREAM Steering Team confirmed the toolkit audiences (primary: community service providers; secondary: persons with dementia and care partners) and identified and evolved content areas. An environmental scan identified few existing, high-quality resources aligned with content areas. The Steering Team, additional multi-perspective partners, and external contractors iteratively co-developed new tools/resources to meet gaps over a 4-month virtual process that included virtual meetings, email exchange of documents and feedback, and one-on-one calls by telephone or email. The final DREAM toolkit includes a website with seven learning modules (on the diversity of dementia, rights and inclusion of persons living with dementia, physical activity, healthy eating, dementia-inclusive practices), a learning manual, six videos, nine handouts, and four wallet cards (www.dementiawellness.ca). Our co-development participants rated the process highly in relation to the principles and enablers of authentic partnership even though all engagement was virtual. Through use of the co-developed DREAM toolkit, we anticipate community service providers will gain the knowledge and confidence needed to provide dementia-inclusive wellness programs and services that benefit persons with dementia and their families.

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Exercise to Improve Postural Stability in Older Adults with Alzheimer’s Disease: A Systematic Review of Randomized Control Trials

Cited by 12 publications

References 26 publications

Falls and Alzheimer Disease

Falls and Alzheimer Disease

Interdisciplinary Approaches to Deal with Alzheimer’s Disease—From Bench to Bedside: What Feasible Options Do Already Exist Today?

Dementia resources for eating, activity, and meaningful inclusion (DREAM) toolkit co-development: process, output, and lessons learned

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