Exercise Tolerance After Beta Blockade in Recent Cardiac Transplant Recipients

Fuentes, Francisco Buendía; Bonet, Luis Almenar; Martínez‐Dolz, Luis; Carranza, María José Sancho-Tello de; López, J. Moro; Ramón-Llin, Jaime Agüero; Sánchez‐Lázaro, Ignacio; Sánchez-Gómez, Juan Miguel; Raso, Rafael; Manchón, Josep Navarro; Sanz, Antonio Salvador

doi:10.1016/j.transproceed.2009.06.007

Cited by 6 publications

(1 citation statement)

References 5 publications

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“…However, complete allograft denervation occurs during the operation, 1) which results in adverse clinical effects including higher heart rates (HR) at rest, slow acceleration of HR during exercise, decreased exercise tolerability, and absence of angina at coronary ischemia. [2][3][4][5][6] Recent clinical and experimental studies have provided evidence of progressive partial sympathetic reinnervation during several years after HTx through HR variability (HRV) analyses, positron emission tomography imaging with the catecholamine analogue C-11 hydroxyephedrine, or hormonal measurement. 3,[7][8][9][10][11][12] However, most studies were executed by cross-sectional observation at several years after HTx, while fewer studies were conducted successively within postoperative 1 year.…”

Section: H Eart Transplantation (Htx) Is the Ultimate Treatment Formentioning

confidence: 99%

Recipients With Shorter Cardiopulmonary Bypass Time Achieve Improvement of Parasympathetic Reinnervation Within 6 Months After Heart Transplantation

et al. 2014

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SummaryAlthough cross-sectional late-phase reinnervation in heart transplantation (HTx) recipients has been demonstrated by several earlier studies, early-phase successive analyses especially for parasympathetic reinnervation remain unknown. Successive heart rate variability (HRV) data calculated by the MemCalc power spectral density method were obtained from 16 non-rejection recipients 1-24 weeks after HTx. High frequency (HF) level representing parasympathetic magnitude increased significantly at 6 months after HTx (from 0.9 ± 0.7 to 4.1 ± 2.8 ms Key words: Sympathetic, Heart rate variability, Memcalc, Donor H eart transplantation (HTx) is the ultimate treatment for patients with stage D heart failure because the deteriorated heart of the recipient is completely replaced with a healthy donor heart. However, complete allograft denervation occurs during the operation, 1) which results in adverse clinical effects including higher heart rates (HR) at rest, slow acceleration of HR during exercise, decreased exercise tolerability, and absence of angina at coronary ischemia.2-6) Recent clinical and experimental studies have provided evidence of progressive partial sympathetic reinnervation during several years after HTx through HR variability (HRV) analyses, positron emission tomography imaging with the catecholamine analogue C-11 hydroxyephedrine, or hormonal measurement. 3,[7][8][9][10][11][12] However, most studies were executed by cross-sectional observation at several years after HTx, while fewer studies were conducted successively within postoperative 1 year. Moreover, little has been investigated about parasympathetic reinnervation. We here analyzed successive HRV parameters 1-24 weeks after HTx to investigate postoperative early-stage parasympathetic reinnervation.

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