Exercise training and depression and anxiety in musculoskeletal pain patients: a meta-analysis of randomized control trials

Amiri, Sohrab

doi:10.1007/s40211-022-00431-2

Cited by 11 publications

(6 citation statements)

References 89 publications

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“…This review and meta-analysis incorporated data from 1,059 HD patients and validated the benefits of intradialytic exercise to reduce the depression level of patients. This is consistent with the findings of previous studies that evinced that exercise training exerts a positive effect on depressive symptoms in HD patients ( 39 ). In this large-scale meta-analysis, in addition to calculating the total effect size of exercise training on depression levels of HD patients, the impact of different exercise parameters, including exercise location, exercise type, total exercise duration, and single exercise duration, was also assessed.…”

Section: Discussionsupporting

confidence: 93%

The effects of exercise training interventions on depression in hemodialysis patients

Yu,

Huang,

Tao

et al. 2024

Front. Psychiatry

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PurposeDepression considerably influences the clinical outcomes, treatment compliance, quality of life, and mortality of hemodialysis patients. Exercise plays a beneficial role in depressive patients, but its quantitative effects remain elusive. This study aimed to summarize the effects of exercise training on depression in patients with end-stage renal disease undergoing hemodialysis.MethodsThe PUBMED, EMBASE, and Cochrane Library databases were systematically searched from inception to April 2023 to identify published articles reporting the effect of exercise training on the depression level of patients with End-Stage Renal Disease undergoing hemodialysis. Data were extracted from the included studies using predefined data fields by two independent researchers. The Cochrane Handbook for Systematic Reviews of Interventions and Joanna Briggs Institute Critical Appraisal Checklist for Quasi-Experimental Studies were employed for quality evaluation.ResultsA total of 22 studies enrolling 1,059 patients who participated in exercise interventions were included. Hemodialysis patients exhibited superior outcomes with intradialytic exercise (SMD = −0.80, 95% CI: −1.10 to −0.49) and lower levels of depression following aerobic exercise (SMD = −0.93, 95%CI: −1.32 to −0.55) compared to combined exercise (c − 0.85, 95% CI: −1.29 to −0.41) and resistance exercise (SMD = −0.40, 95%CI: −0.96 to 0.17). Regarding exercise duration, patients manifested lower depression levels when engaging in exercise activities for a duration exceeding 6 months (SMD = −0.92, 95% CI: −1.67 to −0.17). Concerning the duration of a single exercise session, the most significant improvement was noted when the exercise duration exceeded 60 min (SMD = −1.47, 95% CI: −1.87 to −1.06).ConclusionOur study determined that exercise can alleviate depression symptoms in hemodialysis patients. This study established the varying impacts of different exercise parameters on the reduction of depression levels in hemodialysis patients and is anticipated to lay a theoretical reference for clinicians and nurses to devise tailored exercise strategies for interventions in patients with depression.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, This study was registered in the International Prospective Register of Systematic Reviews (PROSPERO) database, with registration number CRD42023434181.

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Section: Discussionsupporting

confidence: 93%

The effects of exercise training interventions on depression in hemodialysis patients

Yu,

Huang,

Tao

et al. 2024

Front. Psychiatry

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“…Meta‐analytical studies support the efficacy of exercise for improving body composition in individuals with obesity, 84 as well as reducing anxiety and depression 85–87 . In the case of depression, RCTs suggest that moderate‐intensity aerobic exercise is the most effective intervention 86 .…”

Section: Discussionmentioning

confidence: 99%

“…82,83 Meta-analytical studies support the efficacy of exercise for improving body composition in individuals with obesity, 84 as well as reducing anxiety and depression. [85][86][87] In the case of depression, RCTs suggest that moderate-intensity aerobic exercise is the most effective intervention. 86 Regarding aerobic exercise, Irby et al 88 mentioned that this modality is feasible and could be effective as Furthermore, in healthy participants, both aerobic and resistance exercises elicit exercise-induced hypoalgesia, known as the reduction in pain perception during or following a single bout of exercise.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of various exercise interventions for migraine treatment: A systematic review and network meta‐analysis

Reina‐Varona,

Madroñero‐Miguel,

Fierro‐Marrero

et al. 2024

Headache

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ObjectiveTo compare various exercise modalities’ efficacy on migraine frequency, intensity, duration, and disability.BackgroundExercise has been shown to be an effective intervention to reduce migraine symptoms and disability; however, no clear evidence exists regarding the most effective exercise modalities for migraine treatment.MethodsA systematic review was performed in PubMed, PEDro, Web of Science, and Google Scholar. Clinical trials that analyzed the efficacy of various exercise modalities in addressing the frequency, intensity, duration, and disability of patients with migraine were included. Eight network meta‐analyses based on frequentist (F) and Bayesian (B) models were developed to estimate the direct and indirect evidence of various exercise modalities. Standardized mean difference (SMD) and 95% confidence (CI) and credible intervals (CrI) were calculated for each treatment effect based on Hedge's g and p scores to rank the modalities.ResultsWe included 28 studies with 1501 migraine participants. Yoga (F: SMD −1.30; 95% CI −2.09, −0.51; B: SMD −1.33; 95% CrI −2.21, −0.45), high‐intensity aerobic exercise (F: SMD −1.30; 95% CI −2.21, −0.39; B: SMD −1.17; 95% CrI −2.20, −0.20) and moderate‐intensity continuous aerobic exercise (F: SMD −1.01; 95% CI −1.63, −0.39; B: SMD −1.06; 95% CrI −1.74, −0.38) were significantly superior to pharmacological treatment alone for decreasing migraine frequency based on both models. Only yoga (F: SMD −1.40; 95% CI −2.41, −0.39; B: SMD −1.41; 95% CrI −2.54, −0.27) was significantly superior to pharmacological treatment alone for reducing migraine intensity. For diminishing migraine duration, high‐intensity aerobic exercise (F: SMD −1.64; 95% CI −2.43, −0.85; B: SMD −1.56; 95% CrI −2.59, −0.63) and moderate‐intensity continuous aerobic exercise (SMD −0.96; 95% CI −1.50, −0.41; B: SMD −1.00; 95% CrI −1.71, −0.31) were superior to pharmacological treatment alone.ConclusionVery low‐quality evidence showed that yoga, high‐ and moderate‐intensity aerobic exercises were the best interventions for reducing migraine frequency and intensity; high‐ and moderate‐intensity aerobic exercises were best for decreasing migraine duration; and moderate‐intensity aerobic exercise was best for diminishing disability.

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“…3,4 These conditions potentially exacerbate musculoskeletal pain and worsen overall quality of life. [5][6][7][8] While recommendations to simultaneously manage symptomatic OA and comorbid psychiatric illness exist, [9][10][11] there is limited information on the effect of pharmacologic treatment of depression or anxiety on validated OA-related outcomes. Only one study to date exists on this topic, which suggested that pharmacologic treatment of depression in patients with OA is associated with decreased pain severity, improved functional status, and better quality of life.…”

mentioning

confidence: 99%

“…3,4 These conditions potentially exacerbate musculoskeletal pain and worsen overall quality of life. 5-8…”

mentioning

confidence: 99%

Association of Pharmacologic Treatment of Depression/Anxiety With Initial Patient-Reported Outcome Measures in Patients With Hip and Knee Osteoarthritis

Farid,

Liimakka,

Parker

et al. 2024

J Am Acad Orthop Surg

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Introduction: Depression and anxiety are common comorbidities that may exacerbate osteoarthritis (OA)-related pain. We aim to evaluate the effect of pharmacologic treatment of depression/anxiety on hip and knee patient-reported outcome measures (PROMs). Methods: A multi-institutional PROMs database was queried for patients with depression or anxiety and hip or knee OA who completed a PROMs questionnaire at an initial orthopaedic visit between January 2015 and March 2023. Data on demographics, comorbidities, and duration of pharmacologic treatment of depression/anxiety were obtained. Patients were stratified into three cohorts based on treatment duration. PROMs were compared across cohorts. Results: Two thousand nine hundred sixty patients who completed PROMs at their initial orthopaedic visit had both OA and depression/anxiety. One hundred thirty-four (4.5%) received pharmacologic treatment of depression/anxiety for < 1 year, versus 196 (6.6%) for more than 1 year. In unadjusted analyses, patients with pharmacologic treatment had significantly lower Patient-Reported Outcomes Measurement Information System (PROMIS)-Physical (39.8 [IQR 34.9, 44.9] vs 42.3 [37.4, 47.7], P < 0.001) and PROMIS-Mental (43.5 [36.3, 50.8] vs 48.3 [41.1, 53.3], P < 0.001) scores than those without treatment. After adjusting for demographics and comorbidities, only differences in PROMIS-Mental scores remained statistically significant, with pharmacologic treatment associated with lower scores (β = −2.26, 95% CI, [−3.29, −1.24], P < 0.001). On secondary analysis including duration of pharmacologic treatment, < 1 year of treatment was associated with significantly lower PROMIS-Mental scores than those not treated (β = −4.20, 95% CI [−5.77, −2.62], P < 0.001) while scores of patients with more than 1 year of treatment did not differ significantly from those without treatment. Conclusion :Our results indicate that pharmacologic treatment of depression/anxiety is associated with improved psychological health but not with improved physical symptoms related to OA. We observed a nonsignificant trend that patients with depression/anxiety who warrant pharmacologic treatment tend to have worse physical symptoms than those who do not; however, unadjusted analyses suggest this is a complex relationship beyond the isolated effect of pharmacologic treatment.

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Exercise training and depression and anxiety in musculoskeletal pain patients: a meta-analysis of randomized control trials

Cited by 11 publications

References 89 publications

The effects of exercise training interventions on depression in hemodialysis patients

The effects of exercise training interventions on depression in hemodialysis patients

Efficacy of various exercise interventions for migraine treatment: A systematic review and network meta‐analysis

Association of Pharmacologic Treatment of Depression/Anxiety With Initial Patient-Reported Outcome Measures in Patients With Hip and Knee Osteoarthritis

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