Exercise Training as Therapy for Heart Failure

Fleg, Jerome L.; Cooper, Lawton S.; Borlaug, Barry A.; Haykowsky, Mark J.; Kraus, William E.; Levine, Benjamin D.; Pfeffer, Marc A.; Piña, Ileana L.; Poole, David C.; Reeves, Gordon R.; Whellan, David J.; Kitzman, Dalane W.

doi:10.1161/circheartfailure.113.001420

Cited by 146 publications

(113 citation statements)

References 100 publications

(122 reference statements)

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“…Exercise training is now a well‐establish therapy for HF patients,29 and in the last European Society of Cardiology (ESC) HF guideline 2016, ‘patients with HF are recommended to perform properly designed exercise training’ 30. In a recent review titled ‘Exercise as medicine—evidence for prescribing exercise as therapy in 26 different chronic diseases’, Pedersen and Saltin wrote a chapter about HF patients 31.…”

Section: With Heart Failure Present: Exercise Improvement With Trainimentioning

confidence: 99%

“…A meeting in 2012 in Bethesda of the National Heart, Lung, and Blood Institute49 aimed to evaluate, to optimize, and to translate the potential role of exercise training in HF. They identified many possible knowledge gaps and six final recommendations as the highest priority in advancing exercise training as a therapy in HF: (i) better understanding of the basic mechanisms of exercise intolerance, (ii) better knowledge of different phenotypes, (iii) better measurement of the results after training, (iv) improvement in adherence, (v) optimization of training regimens, and (vi) combination of training with other lifestyle interventions.…”

Section: With Heart Failure Present: Exercise Improvement With Trainimentioning

confidence: 99%

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Exercise and heart failure: an update

et al. 2017

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The present update is dedicated to the evolution of the interaction between heart failure (HF) and exercise and how the scientific community has handled it. Indeed, on the one hand, HF is a leading cause of morbidity and mortality with a stable prevalence from 1998 onward varying between 6.3% and 13.3%. On the other hand, exercise is seen as a diagnostic and prognostic tool as well as a therapeutic intervention in chronic HF. More precisely, the knowledge, the clinical application, and the research interest on the mutual interactions between exercise and HF have different phases in disease progression: Before HF onset (past): exercise provides protective benefit in preventing HF (primary prevention).With HF present: exercise improvement with training provides benefits in HF (secondary prevention).The prediction of future in HF patients: exercise impairment, as a leading characteristic of HF, is used as a prognostic factor.

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Section: With Heart Failure Present: Exercise Improvement With Trainimentioning

confidence: 99%

Section: With Heart Failure Present: Exercise Improvement With Trainimentioning

confidence: 99%

Exercise and heart failure: an update

et al. 2017

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“…Cardiac rehabilitation has been convincingly shown to be effective in improving functional capacity and quality of life and to reduce HF hospitalizations in both patients with HFrEF and HFpEF. [112][113][114][115][116] Indeed, the US Centers for Medicare and Medicaid Services has approved coverage for cardiac rehabilitation for stable outpatients with HFrEF. Sadly, only a small fraction of eligible patients are referred to cardiac rehabilitation 117 ; efforts are underway to ensure that exercise training becomes more routine.…”

Section: Exercise Trainingmentioning

confidence: 99%

New Management Strategies in Heart Failure

Owens

Brozena

Jessup

2016

Circulation Research

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“…Cardiac rehabilitation (CR) has been extensively advocated as an important coadjuvant in the treatment of HF (11) (12) . HF-ACTION, a major randomized controlled trial evaluating the effects of CR implementation among patients with HF, showed that after adjustment for prognostic predictors, exercise training reduced all-cause and cardiovascular mortality and hospitalizations, while simultaneously increasing maximum oxygen consumption and health-related quality of life (13) (14) .…”

Section: Introductionmentioning

confidence: 99%

Cardiac rehabilitation program in patients with Chagas heart failure: a single-arm pilot study

Mediano

Mendes

Pinto

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction:The benefit of a cardiac rehabilitation (CR) program for patients with Chagas heart failure (CHF) remains unclear. Therefore, we aimed to investigate the effects of CR for CHF patients. Methods: A single-arm pilot study, including 12 patients with CHF, was performed. Patients participated in an 8-month physical exercise intervention, comprising aerobic, strength, and stretching exercises (3 times per week, 60 minutes per session). Nutritional and pharmaceutical counseling were also performed. Functional capacity (cardiopulmonary exercise test), muscle respiratory strength (manovacuometry), and body composition (anthropometry and skinfolds) were evaluated at baseline, and after 4 and 8 months of intervention. Cardiac function (echocardiography), biomarkers (lipid profile, glucose, and glycated hemoglobin) and quality of life (Minnesota Living with Heart Failure Questionnaire) were assessed at baseline and at the end of the intervention. Results: Seven of 12 patients included in the study completed the 8-month follow-up period. Only 2 moderate adverse events occurred during the exercise training. Functional capacity improved after 4 months of CR, while left ventricular ejection fraction (LVEF) and respiratory strength improved after 8 months. Patients with right ventricular (RV) dysfunction at baseline exhibited an improvement in functional capacity after 4 months, and improvements in left ventricular (LV) diastolic pressure, respiratory strength, and quality of life at the end of follow-up. Conversely, those with normal baseline RV function demonstrated LVEF increases that were not observed in patients with RV dysfunction. Conclusions: CR was feasible, safe, and has important clinical benefits for patients with CHF, specifically for cardiac function and muscle respiratory strength.

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Exercise Training as Therapy for Heart Failure

Cited by 146 publications

References 100 publications

Exercise and heart failure: an update

Exercise and heart failure: an update

New Management Strategies in Heart Failure

Cardiac rehabilitation program in patients with Chagas heart failure: a single-arm pilot study

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