Exercise training attenuates hepatic inflammation, fibrosis and macrophage infiltration during diet induced-obesity in mice

Kawanishi, Noriaki; Yano, Hiromi; Mizokami, Tsubasa; Takahashi, Masaki; Oyanagi, Eri; Suzuki, Katsuhiko

doi:10.1016/j.bbi.2012.04.006

Cited by 109 publications

(99 citation statements)

References 50 publications

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“…However, the expression of F4/80 was significantly lower in the exercise groups than in the high fat diet group. The present finding that exercise training reduces the expression of adipose tissue F4/80 mRNA coincides with previous studies [13,29].…”

Section: Discussionsupporting

confidence: 81%

The effects of either resveratrol or exercise on macrophage infiltration and switching from M1 to M2 in high fat diet mice

Jeong

Lee

Park

et al. 2015

J. Exerc. Nutr, Biochem.

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The effects of either resveratrol or exercise on macrophage infiltration and switching from M1 to M2 in high fat diet mice. JENB., Vol. 19, No. 2, pp.65-72, 2015 [Purpose] The aim of this study was to compare the effectiveness of either resveratrol supplementation or exercise training on macrophage infiltration and switching from M1 to M2 kupffer cells in high fat diet mice.[Methods] C57BL/6 mice were separated into 5 groups: normal diet (ND; n = 6), high-fat diet (HD; n = 6), high-fat diet with resveratrol (HR; n = 6), high-fat diet with exercise (HE; n = 6) or high-fat diet with resveratrol and exercise (HRE; n = 6). Resveratrol supplementation mice were orally gavaged with resveratrol (25mg/kg of body weight) dissolved in 50% propylene glycol. Exercise mice ran on a treadmill at 12-20 m/min for 30-60 min/day, 5 times/week for 12 weeks.[Results] After 12 weeks of intervention, the liver was analyzed. F4/80 expression was evaluated by western blot while CD11c and CD163 mRNA expressions were evaluated by RT-PCR. The weights of the body and liver were significantly increased in the HD and HR group compared to the ND group (p < 0.01). However, the weights were most effectively reduced in the HE and HRE groups compared to the HD group (p < 0.05). The macrophage marker, F4/80 expression was significantly lower in the HE and HRE groups compared to the HD group (p < 0.05). mRNA expression of the M1 macrophage marker, CD11c, in the HD group was significantly increased compared to the ND group (p < 0.01). mRNA expression of the M2 macrophage specific marker, CD163, in the HE and HRE groups were significantly increased compared to the HD group (p < 0.05). The mRNA expressions of TLR4, ICAM-1 and VCAM-1, which induce pro-inflammatory cytokine production, were strongly decreased in the HR, HE, and HRE groups compared to the HD group.[Conclusion] These results suggest that moderate exercise training inhibits macrophage infiltration and up regulation of CD163 expression. However, resveratrol supplementation is not enough to ameliorate obesity-induced macrophage infiltration and switching.

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Section: Discussionsupporting

confidence: 81%

The effects of either resveratrol or exercise on macrophage infiltration and switching from M1 to M2 in high fat diet mice

Jeong

Lee

Park

et al. 2015

J. Exerc. Nutr, Biochem.

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“…Additionally, it is known that obesity affects the balance in macrophage polarization within white adipose tissue (1) and similar imbalances may promote inflammation and fibrosis through stellate cell activation in the liver (18, 29). M1 polarized macrophages promote the release of pro-inflammatory cytokines while alternatively activated, or M2 polarized macrophages, promote anti-inflammatory responses (10).…”

Section: Discussionmentioning

confidence: 99%

“…M1 polarized macrophages promote the release of pro-inflammatory cytokines while alternatively activated, or M2 polarized macrophages, promote anti-inflammatory responses (10). Recently, M1 polarization markers have been shown to be elevated in animal models of NASH (18) and diet induced obesity (49). The current findings support these limited investigations, with observed elevations in hepatic mRNA expression of M1/inflammatory markers CD11c, IL-1β, and TNFα in the obese, O-SED rats.…”

Section: Discussionmentioning

confidence: 99%

Treating NAFLD in OLETF Rats with Vigorous-Intensity Interval Exercise Training

Linden

Fletcher

Morris

et al. 2015

Medicine &Amp; Science in Sports &Amp; Exercise

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Background There is increasing use of high intensity, interval type exercise training in the management of many lifestyle-related diseases. Purpose To test the hypothesis that vigorous-intensity, interval exercise is as effective as traditional, moderate-intensity aerobic exercise training on nonalcoholic fatty liver disease (NAFLD) outcomes in obese, Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Methods OLETF rats (age 20 wks; n= 8–10/group) were assigned to sedentary (O-SED), moderate-intensity exercise training (O-MOD EX; 20 meters/min, 15% incline, 60 min/d, 5 d/wk treadmill running), or vigorous-intensity interval exercise training (O-VIG EX; 40 meters/min, 15% incline, 6×2.5 min bouts/d, 5 d/wk treadmill running) groups for 12 weeks. Results Both MOD EX and VIG EX effectively lowered hepatic triglycerides (TGs), serum ALTs, perivenular fibrosis, and hepatic collagen 1α1 mRNA expression (vs. O-SED, p<0.05). In addition, both interventions increased hepatic mitochondrial markers (citrate synthase activity and fatty acid oxidation) and suppressed markers of de novo lipogenesis (FAS, ACC, Elovl6, and SCD-1); whereas, only MOD EX increased hepatic mitochondrial β-HAD activity and hepatic TG export marker apoB100 and lowered fatty acid transporter CD36 compared with O-SED. Moreover, while total hepatic macrophage population markers (CD68 and F4/80 mRNA) did not differ among groups, MOD EX and VIG EX lowered M1 macrophage polarization markers (CD11c, IL-1β, and TNFα mRNA) and MOD EX increased M2 macrophage marker, CD206 mRNA, compared with O-SED. Conclusions The accumulation of 15 min/day of VIG EX for 12 weeks had similar effectiveness as 60 min/day of MOD EX in the management of NAFLD in OLETF rats. These findings may have important health outcome implications as we work to design better exercise training programs for NAFLD patients.

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“…Likewise, exhaustive exercise reduces TNF-alpha and IFN-alpha concentrations and this reduction is via TLR-7 and elevation of systemic catecholamines [47]. Further, hepatic inflammation and fibrosis is reduced by reduction of TNF-alpha, macrophage infiltration and tissue inhibitor of matrix metalloproteinase-1 mRNA [48]. It is clear that factors released by exercise, such as IL-6 and decreasing levels of TNF-alpha production, lead to a decreased inflammatory state.…”

Section: B Exercise and Anti-inflammatory Effectsmentioning

confidence: 98%

Physical and Immunological Aspects of Exercise in Chronic Diseases

et al. 2014

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Physical inactivity and sedentary lifestyles are believed to be independent risk factors for the occurrence of numerous diseases, including, obesity, Type 2 diabetes, metabolic syndrome, cardiovascular disease, cancer and mental health, all leading to substantial morbidity and/or premature death. It has been found that regular exercise, is associated with better quality of life and health outcomes, and reduces the risk of cardiovascular disease and cancer. Here, we review the effects regular exercise has on mental health and well-being, on the immune system and in cancer, cardiovascular disease, autoimmunity and metabolic syndrome. Is exercise the new immunotherapy to treat diseases?

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Exercise training attenuates hepatic inflammation, fibrosis and macrophage infiltration during diet induced-obesity in mice

Cited by 109 publications

References 50 publications

The effects of either resveratrol or exercise on macrophage infiltration and switching from M1 to M2 in high fat diet mice

The effects of either resveratrol or exercise on macrophage infiltration and switching from M1 to M2 in high fat diet mice

Treating NAFLD in OLETF Rats with Vigorous-Intensity Interval Exercise Training

Physical and Immunological Aspects of Exercise in Chronic Diseases

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