Exercise Training Attenuates Neuropathic Pain and Cytokine Expression After Chronic Constriction Injury of Rat Sciatic Nerve

Abstract

These results suggest that progressive exercise training decreases peripheral neuropathic pain as well as TNF-α and IL-1β overproduction and increases HSP72 expression after CCI of the sciatic nerve.

Effect of Endurance Exercise Training on Kinesin - 5 and Dynein Motor Proteins in Sciatic Nerves of Male Wistar Rats with Diabetic Neuropathy

“…The obtained results from this study showed that increased activity in the form of moderate endurance exercise can improve neuropathic pain responses in mechanical allodynia and thermal hyperalgesia. This result is consistent with some studies suggesting the significant effects of exercise training on neuropathic pain responses in various pain models (11,15). Conversely, some studies have failed to confirm the effects of exercise training on improvement of neuropathic pain (17).…”

“…Exercise can also be accompanied by RNA biosynthesis, increased axonal transport, and increased neural sprouting followed by nerve cut (10). In contrast, the majority of observed sensory and motor nerves disorders in diabetic neuropathy are attributed to mitochondrial disorders in different parts of neurons, and multiple synaptic deficits (5,11,12). With regard to the involvement of neural motor proteins disorder in many of neurodegenerative diseases, so it is possible that they also have a role in loss of sensory and motor neurons caused by diabetic neuropathy disease.…”

Regular physical activity prevents development of chronic pain and activation of central neurons

“…In all three conditions, mechanical hyperalgesia was reduced compared with sedentary controls. However, the study, which was confirmed by a subsequent study, shows that exercise reduces local inflammatory mediators and nerve degeneration induced by the nerve injury (5,10). Thus the decrease in mechanical hyperalgesia in the nerve injury studies could be directly related to the decrease in inflammation and injury.…”

Exercise-Induced Hypoalgesia Profile in Rats Predicts Neuropathic Pain Intensity Induced by Sciatic Nerve Constriction Injury

“…The predominant exercise stimulus in animal studies of EIH are forced swimming 8,42,44,62 and treadmill, 10,53 which are considered stressful condition for rodents. 15,41,72 Stress is known to have an effect on pain behavior (increase or decrease), and the hypoalgesic effect demonstrated in these models may be a combination of EIH and the effect induced by stress.…”