Exercise training combined with angiotensin II receptor blockade limits post-infarct ventricular remodelling in rats

Abstract

Our results suggest that post-MI exercise training and/or AngII receptor blockade reduces TIMP-1 expression and mitigates the expressions of ACE and AT1 receptor. These improvements, in turn, attenuate myocardial fibrosis and preserve post-MI cardiac function.

Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-α-induced injury

“…A polyethylene catheter ( 26 ) was inserted into the left ventricle (LV) through the right carotid artery for measurement of left ventricular end diastolic pressure (LVEDP) and maximum left ventricular pressure ascending speed (+dp/dt max) ( 26 ).…”

Effect of exercise associated with stem cell transplantation on ventricular function in rats after acute myocardial infarction

“…In another study by Xu et al [23], they have shown that, in infarcted trained rats, after early physical activity, the percentage of collagen in the trained group was significantly higher in the sedentary group, suggesting that early training after MI reduces the metalloproteinases expression. In this study, this finding was not identified because there was a greater presence of collagen in the trained group without cells.…”

Effect of endurance exercise training on morphological changes in rat heart tissue following experimental myocardial infarction

“…In other words, endurance training following infarction, resulted in enhancement of cardiac hypertrophy. Previous studies have shown that endurance training after MI can have a beneficial effect (9,13,14), without affecting (6, 7, 10, 12) or adverse effects (11,15) on cardiac function and remodeling. The results of this study showed that endurance training running on a treadmill after MI increased the rate of necrosis damage and infarct size compared with the control group (no training).…”

“…Endurance exercise protocol continued for 4 weeks. This exercise regimen intensity is average about 55% of maximal oxygen consumption (VO2max ) and is well tolerated by infarcted rats (9,17). In order to neutralize the effect of potential stress of the animals on the treadmill, healthy and control groups were placed on the device for 5 minutes once a day at a speed of 5 m/min daily.…”

“…They also reported that exercise training, resulted in additional scar thinning (7). Xu et al (2008) suggested that post-MI exercise training attenuate myocardial fibrosis and preserve post-MI cardiac function (9). In this context, De Waard et al (2007) investigated the effect of 8 weeks of endurance exercise training, beginning 24 hours after MI in infarcted rats.…”