Exercise training decreases plasma cholesteryl ester transfer protein.

Seip, Richard L.; Moulin, Philippe; Cocke, T; Tall, Alan R.; Kohrt, Wendy M.; Mankowitz, Keith; Semenkovich, Clay F.; Ostlund, Richard E.; Schonfeld, Gustav

doi:10.1161/01.atv.13.9.1359

Cited by 145 publications

(78 citation statements)

References 37 publications

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“…As in a previous study [16], we were unable to detect significant differences in CETP activity between males and females. This is in line with published data on CETP mass in elderly, sedentary subjects [22], as well as CETP activity (measured with exogenous substrates) in marathon runners aged 25-51 years [23].…”

Section: Discussionsupporting

confidence: 92%

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Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man

Tol¹,

Zock²,

Gent³

et al. 1995

Atherosclerosis

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The average diet may provide some 8-10 g/day of unsaturated fatty acids with a trans double bond. Previous studies showed that dietary trans fatty acids may simultaneously raise low-density lipoprotein (LDL) cholesterol and reduce high-density lipoprotein (HDL) cholesterol. Human plasma contains a protein (CETP) which transfers cholesterylesters from HDL to lipoproteins of lower density. We hypothesized that CETP could play a role in the effect of trans fatty acids on lipoproteins and measured the activity levels of CETP in serum samples from a 9-week study in which 55 volunteers were fed three controlled diets with different fatty acid profiles. Mean activity was 114 (% of reference serum) after consumption of a high trans fatty acid diet, as opposed to 96 after linoleic acid and 97 after stearic acid (P < 0.02). We conclude that the increased activity of CETP may contribute to the rise in LDL cholesterol and the fall in HDL cholesterol seen on diets with high contents of trans fatty acids.

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Section: Discussionsupporting

confidence: 92%

“…Recent data indicate an effect of exercise on plasma CETP activity [22,23], but our study subjects (aged 19-49 years) did not change their excercise habits during the course of the experiment [3]. As in a previous study [16], we were unable to detect significant differences in CETP activity between males and females.…”

Section: Discussionmentioning

confidence: 68%

Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man

Tol¹,

Zock²,

Gent³

et al. 1995

Atherosclerosis

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“…In this regard, CETP action itself is directed by the composition of various lipoproteins. Lifestyle factors further complicate this issue: it has been described that alcohol abuse and physical exercise, typically associated with increased HDL-c, are associated with diminished CETP concentration (55,71,72). Similarly, smoking (associated with low HDL-c) is associated with high CETP activity (73,74).…”

Section: Cetp and Dyslipidemia Which Comes First?mentioning

confidence: 99%

A review of CETP and its relation to atherosclerosis

Grooth

Klerkx

Stroes

et al. 2004

Journal of Lipid Research

235

150

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“…In a normolipidemic population, the plasma CETP concentration varies mostly over a threefold range and is influenced by environmental factors (6). Plasma CETP has been shown to be elevated in smokers and to be decreased by heavy alcohol drinking and physical training (7)(8)(9).…”

mentioning

confidence: 99%

Relationship Between TaqIB Cholesteryl Ester Transfer Protein Gene Polymorphism and Macrovascular Complications in Japanese Patients With Type 2 Diabetes

et al. 2002

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Cholesteryl ester transfer protein (CETP) is a key regulating factor of lipid metabolism, and the polymorphism of its gene may therefore be a candidate for modulating the lipid parameters, altering the susceptibility to atherosclerosis in type 2 diabetic subjects. In a group of 443 unrelated Japanese patients with type 2 diabetes, we studied the B1B2 polymorphism at the CETP locus, which is detectable with the restriction enzyme TaqI. Patients were separated into three groups according to genotype and compared based on their clinical characteristics, lipid parameters, and macrovascular complications. The B2 allele was associated in a dose-dependent fashion with higher HDL cholesterol and apolipoprotein AI levels, together with lower CETP concentrations. Furthermore, the prevalence of macrovascular complications, such as coronary heart disease, arteriosclerosis obliterans, and cerebral vascular disease, was significantly higher in subjects with the B1B1 genotype. Multiple logistic regression analysis also showed that the B1 allele of CETP genotype was associated with the incidence of these three complications independently of other risk factors. Thus, in type 2 diabetic patients, the B1B2 polymorphism of CETP gene is likely to be a strong genetic predictor of macrovascular complications. Diabetes 51:871-874, 2002 T ype 2 diabetic patients are at high risk of atherosclerotic diseases, such as coronary heart disease (CHD), cerebral vascular disease (CVD), or arteriosclerosis obliterans (ASO) (1). This increased risk can be partly accounted for by the lipoprotein disorders linked to insulin resistance: elevated VLDL, triglycerides, and cholesterol, together with low HDL cholesterol (2). The inverse relationship between the level of HDL cholesterol and the risk of cardiovascular disease is commonly explained by the crucial role of HDL in reverse cholesterol transport (3-5). By this process, cholesterol from peripheral cells is taken up by HDL and transported to the liver, where it is metabolized and excreted in the bile. Cholesteryl ester transfer protein (CETP) has a central role in the metabolism of HDL lipoprotein and may therefore alter the susceptibility to atherosclerotic vascular disease (3). In a normolipidemic population, the plasma CETP concentration varies mostly over a threefold range and is influenced by environmental factors (6). Plasma CETP has been shown to be elevated in smokers and to be decreased by heavy alcohol drinking and physical training (7-9).Recently, the B1B2 polymorphism of intron 1 of the CETP gene (presence or absence of a TaqIB restriction site) was shown to be a determinant of HDL cholesterol (10). It has been reported that both healthy and type 2 diabetic subjects with the B2B2 genotype of TaqIB polymorphism have significantly higher HDL cholesterol levels than those with the B1B1 or B1B2 genotype (11,12). Furthermore, in subjects with the B2B2 genotype, the progression of coronary atherosclerosis is more greatly suppressed by pravastatin than in those with the B1B1 or B1B2 genotype,...

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Exercise training decreases plasma cholesteryl ester transfer protein.

Cited by 145 publications

References 37 publications

Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man

Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man

A review of CETP and its relation to atherosclerosis

Relationship Between TaqIB Cholesteryl Ester Transfer Protein Gene Polymorphism and Macrovascular Complications in Japanese Patients With Type 2 Diabetes

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