Exercise Training Fails to Modify Arterial Baroreflex Sensitivity in Ovariectomized Female Rats

Minami, Naoyoshi; Mori, Nobuyoshi; Nagasaka, Makoto; Itoh, Osamu; Ogawa, Morimasa; Kurosawa, Hájíme; Kanazawa, Masayuki; Kohzuki, Masahiro

doi:10.1620/tjem.211.339

Cited by 7 publications

(3 citation statements)

References 52 publications

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“…Additionally, Minami et al reported that ovariectomized rats at 20 weeks of age showed impairment in both baroreflex components, which supports the results observed in the present study. However, we cannot discard a sex difference in cardiovascular control, but apparently the time of castration may have been an important influence on the observed impairment.…”

Section: Discussionsupporting

confidence: 92%

Low dose of methyltestosterone in ovariectomised rats improves baroreflex sensitivity without geno‐ and cytotoxicity

Terra

Lima

Nascimento

et al. 2016

Fundamemntal Clinical Pharma

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This study evaluated the effects of the isolated use of a low dose of methyltestosterone (MT) on cardiovascular reflexes and hormonal levels and its geno- and cytotoxic safety in ovariectomized rats. Female Wistar rats were divided into four groups (n = 6), respectively: SHAM (received vehicle methylcellulose 0.5%), SHAM + MT (received MT 0.05 mg/kg), OVX (received vehicle), and OVX + MT (received MT). Twenty-one days after ovariectomy, treatment was given orally daily for 28 days. The Bezold-Jarisch reflex (BJR) was analyzed by measuring the bradycardic and hypotensive responses elicited by phenylbiguanide (PBG) administration. The baroreflex sensitivity (BRS) was evaluated by phenylephrine and sodium nitroprussite. Myocyte hypertrophy was determined by morphometric analysis of H&E stained slides. Biochemical data were analyzed, as well as micronucleus assay. MT improved BRS and increased testosterone values, but did not change estradiol in the OVX group. MT did not promote changes in mean arterial pressure, heart rate, BJR, serum concentrations of troponin I, weight and histopathology of the heart. MT was able to restore the BRS in OVX rats. The geno- and cytotoxic safety of the MT was demonstrated by the absence of an increase in the micronucleus (PCEMN) or change in the ratio between normochromatic erythrocytes and polychromatic erythrocytes (NCE/PCE).

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Section: Discussionsupporting

confidence: 92%

Low dose of methyltestosterone in ovariectomised rats improves baroreflex sensitivity without geno‐ and cytotoxicity

Terra

Lima

Nascimento

et al. 2016

Fundamemntal Clinical Pharma

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“…The failure of Ex and combined treatment (Cap + Ex) on reducing BP could be related to an impaired baroreceptor reflex. Baroreceptors are the structures responsible for promoting compensatory bradycardia and reducing BP in response to physical activity, and there are reports indicating that baroreceptor reflex is impaired in hypoestrogenic rats . This issue can explain why the BP remained elevated in the Ex and combination (Cap + Ex) groups.…”

Section: Discussionmentioning

confidence: 99%

Topical capsaicin cream with moderate exercise protects against hepatic steatosis, dyslipidemia and increased blood pressure in hypoestrogenic obese rats

et al. 2020

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BACKGROUND The aim of this study was to evaluate the effects of capsaicin (Cap), moderate exercise (Ex), and their combination on arterial blood pressure (BP) and metabolic complications in hypoestrogenic (HE) obese (HEOb) rats. Female Wistar rats were ovariectomized and given 300 g L−1 sucrose solution (HEOb), or purified water (HE) ad libitum, for 28 weeks. After shaving the abdominal skin, cold cream vehicle was applied to sedentary (Sed) and exercise (Ex) groups, and 0.75 g kg−1 Cap cream was applied to Ex groups. Ex groups ran on a treadmill every day for 20 min at speeds from 0.15 to 0.3 m s−1. For combination groups (Cap + Ex), topical Cap was applied 90 min before Ex. The treatments were performed for 6 weeks, and BP was recorded before and at the end of the experimental protocol. The animals were killed by decapitation, and blood and tissues were obtained to perform oxidative profile, as well as to undertake biochemical and histologic studies. RESULTS Compared with individual treatments, the combined therapy (Cap + Ex) in HEOb rats caused a higher reduction in the caloric intake, body weight, abdominal fat percentage, oxidative stress, and hepatic steatosis. In HEOb groups, Cap was the only treatment that reduced BP and prevented dyslipidemia and oxidative stress. CONCLUSION The present data show that Cap improves the metabolic alterations induced by obesity and hypoestrogenism, suggesting that Cap can be considered as an excellent candidate for therapy of these clinical conditions. © 2020 Society of Chemical Industry

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“…BRS is reduced in individuals with hypertension, coronary heart disease or congestive heart failure [28]. In addition, BRS is reduced with advancing age, even in healthy subjects [29, 30]. However, in women, postmenopausal hypertension is often associated with cardiovascular autonomic alterations, such as a predominance of sympathetic control of the heart rate and decreases in BRS [31], to a greater extent than in age-matched men [32].…”

Section: Mechanisms Responsible For Postmenopausal Hypertension and Rmentioning

confidence: 99%

A Single Pill to Treat Postmenopausal Hypertension? Not Yet

Yanes

Romero²,

Iliescu³

et al. 2011

CTMC

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Postmenopausal women make up one of the fastest growing populations in the United States. Women typically have a higher incidence of cardiovascular disease following menopause. One of the major risk factors for cardiovascular disease is hypertension, and after menopause, blood pressure (BP) increases progressively in women. Also after menopause, the progression of renal disease increases in women compared with aged matched men. However, the mechanism(s) responsible for the postmenopausal increase in BP and renal injury are yet to be elucidated. Moreover the best therapeutic options to treat postmenopausal hypertension in women are not clear. Hypertension in postmenopausal women are usually associated with other cardiovascular risk factors, such as dyslipidemias, visceral obesity and endothelial dysfunction. Recently it became apparent that in a large number of hypertensive postmenopausal women, their BP is not well controlled with conventional antihypertensive medications. A clear understanding of the complex pathogenesis of postmenopausal hypertension is needed in order to offer the best therapeutic options for these women.

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Exercise Training Fails to Modify Arterial Baroreflex Sensitivity in Ovariectomized Female Rats

Cited by 7 publications

References 52 publications

Low dose of methyltestosterone in ovariectomised rats improves baroreflex sensitivity without geno‐ and cytotoxicity

Low dose of methyltestosterone in ovariectomised rats improves baroreflex sensitivity without geno‐ and cytotoxicity

Topical capsaicin cream with moderate exercise protects against hepatic steatosis, dyslipidemia and increased blood pressure in hypoestrogenic obese rats

A Single Pill to Treat Postmenopausal Hypertension? Not Yet

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