Exercise Training for the Elderly: Inflammaging and the Central Role for HSP70

Muller, Carlos Henrique de Lemos; Matos, Jorge Roberto de; Grigolo, Gisele Bettú; Schroeder, Helena Trevisan; Rodrigues-Krause, Josianne; Krause, Maurício

doi:10.1007/s42978-019-0015-6

Cited by 14 publications

(18 citation statements)

References 137 publications

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“…Of uttermost relevance, is the fact that the retention of physical fitness in detraining might contribute to reducing the previously mentioned inflammation, immunosenescence, neuroendocrine dysfunctions and co-morbidities associated with deconditioning, sedentary behaviours and aging [ 9 , 15 , 16 , 28 , 35 ]. It might also help to delay the impairment in the cognitive status [ 9 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Short and Long-Term Trainability in Older Adults: Training and Detraining Following Two Years of Multicomponent Cognitive—Physical Exercise Training

Blasco-Lafarga

Cordellat

Forte

et al. 2020

IJERPH

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Despite the benefits of multicomponent physical–cognitive training programs (MCCogTPs), lower training intensities in the concurrent approach, and bigger heterogeneity with aging, suggest the need for long-term analyses, with special attention to training and detraining in older adults. The present study aims to examine these training/detraining effects in a two year MCCogTP, looking for specific dynamics in the trainability of their physical and cognitive capacities. The intervention was divided into four periods: T1, T2 (8 months of training each), and D1, D2 (3.5 months of detraining plus 0.5 of testing each). Twenty-five healthy seniors (70.82 ± 5.18 years) comprised the final sample and were assessed for cardiovascular fitness (6-minutes walking test), lower-limbs strength (30-seconds chair-stand test) and agility (8-feet timed up-and-go test). Inhibition (Stroop test) was considered for executive function. Physical and cognitive status improved significantly (p < 0.05) throughout the two years, with larger enhancements for physical function (mainly strength and agility). Strength and cardiovascular fitness were more sensitive to detraining, whilst agility proved to have larger training retentions. Inhibition followed an initial similar trend, but it was the only variable to improve along D2 (d = 0.52), and changes were not significant within periods. Notwithstanding aging, and the exercise cessation in D2, physical and cognitive status remained enhanced two years later compared to baseline, except for lower-limb strength. According to these results, basic physical capacities are very sensitive to training/detraining, deserving continuous attention (especially strength). Both reducing detraining periods and complementary resistance training should be considered. Additionally, physical enhancements following MCcogTPs may help cognition maintenance during detraining.

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Section: Introductionmentioning

confidence: 99%

Short and Long-Term Trainability in Older Adults: Training and Detraining Following Two Years of Multicomponent Cognitive—Physical Exercise Training

Blasco-Lafarga

Cordellat

Forte

et al. 2020

IJERPH

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“…Evidence suggests that the inflammatory profile is directly connected with the unfavourable changes in body composition [33,37]. For example, the expansion of the adipose tissue (specially visceral) leads to increased recruitment of blood monocytes and their polarization to inflammatory cells (M1 phenotype) [14].…”

Section: Heat Shock Response In Insulin Resistant Subjects: the Role mentioning

confidence: 99%

“…As a model it is possible to test HSR in human peripheral blood mononuclear cells (PBMC), a major source of circulating HSP72 and representative of immune cell stress response [14]. These cells, in normal and optimal conditions, can express and release HSP72, under heat stress conditions.…”

Section: How To Measure the Heat Shock Response?mentioning

confidence: 99%

“…The difference between concentration at 37 °C and 42 °C is used as a HSR index. The full protocol is described elsewhere [14] and is present in Fig. 3.…”

Section: How To Measure the Heat Shock Response?mentioning

confidence: 99%

“…The control of the inflammatory response depends, of course, on its mediators (cytokines, LPS, among others), but also on a series of programmed mechanisms for resolving inflammation, such as the heat shock response pathway. This molecular pathway is required for physiological adjustments in proteostasis and normal stress adaptation [14]. Recent evidence has shown that the HSR pathway, an important inflammation resolution pathway, is reduced in patients with metabolic disease [15].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Coronavirus infection (SARS-CoV-2) in obesity and diabetes comorbidities: is heat shock response determinant for the disease complications?

Krause

Gerchman

Friedman

2020

Diabetol Metab Syndr

Self Cite

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Chronic inflammation is involved in the pathogenesis of several metabolic diseases, such as obesity and type 2 diabetes mellitus (T2DM). With the recent worldwide outbreak of coronavirus disease (SARS-CoV-2), it has been observed that individuals with these metabolic diseases are more likely to develop complications, increasing the severity of the disease and a poorer outcome. Coronavirus infection leads to the activation of adaptive and innate immune responses, resulting in massive inflammation (to so called cytokine storm), which in turn can lead to damage to various tissues, septic shock and multiple organ failure. Recent evidence suggests that the common link between metabolic diseases and SARS-CoV-2 is the inflammatory response (chronic/low-grade for metabolic diseases and acute/intense in coronavirus infection). However, the ability of the infected individuals to resolve the inflammation has not yet been explored. The heat shock response (HSR), an important anti-inflammatory pathway, is reduced in patients with metabolic diseases and, consequently, may impair inflammation resolution and control in patients with SARS-CoV-2, thus enabling its amplification and propagation through all tissues. Herein, we present a new hypothesis that aims to explain the increased severity of SARS-CoV-2 infection in people with metabolic diseases, and the possible benefits of HSR-inducing therapies to improve the inflammatory profile in these patients.

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Effects of resistance training on heat shock response (HSR), HSP70 expression, oxidative stress, inflammation, and metabolism in middle-aged people

de Lemos Muller,

Schroeder,

Farinha

et al. 2023

J Physiol Biochem

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Exercise Training for the Elderly: Inflammaging and the Central Role for HSP70

Cited by 14 publications

References 137 publications

Short and Long-Term Trainability in Older Adults: Training and Detraining Following Two Years of Multicomponent Cognitive—Physical Exercise Training

Short and Long-Term Trainability in Older Adults: Training and Detraining Following Two Years of Multicomponent Cognitive—Physical Exercise Training

Coronavirus infection (SARS-CoV-2) in obesity and diabetes comorbidities: is heat shock response determinant for the disease complications?

Effects of resistance training on heat shock response (HSR), HSP70 expression, oxidative stress, inflammation, and metabolism in middle-aged people

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