Exercise training improves autonomic function and inflammatory pattern in women with polycystic ovary syndrome (PCOS)

Giallauria, Francesco; Palomba, Stefano; Maresca, Luca; Vuolo, Laura; Tafuri, Domenico; Lombardi, Gaetano; Colao, Annamaria; Vigorito, Carlo; Orio, Francesco

doi:10.1111/j.1365-2265.2008.03305.x

Cited by 90 publications

(164 citation statements)

References 38 publications

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“…Indeed, in these young pre-adulthood animals, dietary energy restriction and exercise improved estrous cyclicity and SHBG concentrations. Although not measured in this study, improvements in cardiometabolic and ovarian function following dietary energy restriction and exercise may also be related to favourable effects on inflammatory pathways in conditions of obesity, IR and PCOS (Giallauria et al 2008, Ojeda-Ojeda et al 2013, Gower & Goss 2015. Despite the potential benefits of combining dietary energy restriction and exercise on reproductive function in obese PCOS phenotypes, the central molecular mechanisms have remained unclear.…”

Section: Hypothalamic Arc Neuropeptide and Peptide Expressionmentioning

confidence: 88%

Cardiometabolic and reproductive benefits of early dietary energy restriction and voluntary exercise in an obese PCOS-prone rodent model

Diané

Kupreeva

Borthwick

et al. 2015

Journal of Endocrinology

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Polycystic ovary syndrome (PCOS) is one of the most common endocrine-metabolic disorders in women of reproductive age characterized by ovulatory dysfunction, hyperandrogenism and cardiometabolic risk. The overweight-obese PCOS phenotype appears to have exacerbated reproductive dysfunction and cardiometabolic risk. In overweight-obese adult women with PCOS, exercise and energy restricted diets have shown limited and inconsistent effects on both cardiometabolic indices and reproductive outcomes. We hypothesized that an early lifestyle intervention involving exercise and dietary energy restriction to prevent or reduce the propensity for adiposity would modulate reproductive indices and cardiometabolic risk in an obese PCOS-prone rodent model. Weanling obese PCOS-prone and Lean-Control JCR:LA-cp rodents were given a chow diet ad libitum or an energyrestricted diet combined with or without voluntary exercise (4 h/day) for 8 weeks. Dietary energy restriction and exercise lowered total body weight gain and body fat mass by 30% compared to free-fed sedentary or exercising obese PCOS-prone animals (P!0.01). Energy restriction induced an increase in exercise intensity compared to free-feeding plus exercise conditions. Energy restriction and exercise decreased fasting plasma triglycerides and apoB48 concentrations in obese PCOS-prone animals compared to free-fed and exercise or sedentary groups. The energy restriction and exercise combination in obese PCOS-prone animals significantly increased plasma sex-hormone binding globulin, hypothalamic cocaine-and amphetamine-regulated transcript (CART) and Kisspeptin mRNA expression to levels of the Lean-Control group, and this was further associated with improvements in estrous cyclicity. The combination of exercise and dietary energy restriction when initiated in early life exerts beneficial effects on cardiometabolic and reproductive indices in an obese PCOS-prone rodent model, and this may be associated with normalization of the hypothalamic neuropeptides, Kisspeptin and CART.

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Section: Hypothalamic Arc Neuropeptide and Peptide Expressionmentioning

confidence: 88%

Cardiometabolic and reproductive benefits of early dietary energy restriction and voluntary exercise in an obese PCOS-prone rodent model

Diané

Kupreeva

Borthwick

et al. 2015

Journal of Endocrinology

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“…Of the total 421 participants, 223 received exercise intervention. PCOS diagnosis was confirmed in six of the eight studies by the European Society for Human Reproduction and Embryology/ American Society of Reproductive Medicine (Rotterdam) criteria (Bruner et al, 2006;Vigorito et al, 2007;Giallauria et al, 2008;Palomba et al, 2008;Thomson et al, 2008), in one study by National Institute of Health criteria (Brown et al, 2009), while one study used diagnosis consistent with the Rotterdam criteria but prior to its conception (Randeva et al, 2002). The mean age of participants varied, ranging from 22 to 36 years.…”

Section: Data Synthesismentioning

confidence: 99%

“…Exercise intervention duration varied with the most common duration either 12 (Bruner et al, 2006;Vigorito et al, 2007;Giallauria et al, 2008) or 24 weeks (Randeva et al, 2002;Palomba et al, 2008;Brown et al, 2009), with two studies reporting 16 (Stener-Victorin et al, 2009) and 20 weeks duration (Thomson et al, 2008). The frequency of exercise sessions included three sessions per week in five studies (Bruner et al, 2006;Vigorito et al, 2007;Giallauria et al, 2008;Palomba et al, 2008;Stener-Victorin et al, 2009), four in one (Brown et al, 2009) and five sessions per week in another (Thomson et al, 2008).…”

Section: Data Synthesismentioning

confidence: 99%

“…The frequency of exercise sessions included three sessions per week in five studies (Bruner et al, 2006;Vigorito et al, 2007;Giallauria et al, 2008;Palomba et al, 2008;Stener-Victorin et al, 2009), four in one (Brown et al, 2009) and five sessions per week in another (Thomson et al, 2008). Randeva et al progressively increased exercise prescription from three to seven sessions per week over 6 months (Randeva et al, 2002).…”

Section: Data Synthesismentioning

confidence: 99%

“…antiandrogens, ovulation induction agents, glucocorticoids, antiobesity drugs), renal impairment, hyperglycaemia (.6.9 mmol/l) or Type 1 or 2 diabetes, hormonal contraceptive use, recent breastfeeding (,3 months), pregnancy or planned pregnancy and smoking. Thomson et al, 2008) and four did not specifically aim to induce weight loss (Randeva et al, 2002;Giallauria et al, 2008;Brown et al, 2009;Stener-Victorin et al, 2009).…”

Section: Data Synthesismentioning

confidence: 99%

See 2 more Smart Citations

Exercise therapy in polycystic ovary syndrome: a systematic review

Harrison¹,

Lombard²,

Moran³

et al. 2010

Human Reproduction Update

203

190

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background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting 8 -12% of women. Lifestyle modification, including increased physical activity, is the first-line approach in managing PCOS. A systematic review was performed to identify and describe the effect of exercise as an independent intervention on clinical outcomes in PCOS.methods: Five databases were searched with no time limit. A pre-specified definition of PCOS was not used. Studies were included if exercise therapy (aerobic and/or resistance) could be evaluated as an independent treatment against a comparison group. Outcomes measured included cardiovascular risk factors [insulin resistance (IR), lipid profiles, blood pressure and weight] and reproductive measures (ovulation, menstrual regularity and fertility outcomes). Quality analysis was performed based on the Cochrane Handbook of Systematic Reviews and the Quality of Reporting of Meta-Analyses checklist.results: Eight manuscripts were identified (five randomized controlled trials and three cohort studies). All studies involved moderate intensity physical activity and most were of either 12 or 24 weeks duration with frequency and duration of exercise sessions ranging between studies. The most consistent improvements included improved ovulation, reduced IR (9 -30%) and weight loss (4.5 -10%). Improvements were not dependant on the type of exercise, frequency or length of exercise sessions.conclusions: Exercise-specific interventions in PCOS are limited. Studies vary considerably in design, intensity and outcome measures; therefore conclusive results remain elusive. Larger, optimally designed studies are needed to both gain insights into the mechanisms of exercise action and to evaluate the public health impact of exercise of PCOS.

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Lifestyle changes in women with polycystic ovary syndrome

Moran

Hutchison

Norman

et al. 2011

Cochrane Database of Systematic Reviews

126

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Exercise training improves autonomic function and inflammatory pattern in women with polycystic ovary syndrome (PCOS)

Abstract: Exercise training improves autonomic function and inflammatory pattern in PCOS women.

Cited by 90 publications

References 38 publications

Cardiometabolic and reproductive benefits of early dietary energy restriction and voluntary exercise in an obese PCOS-prone rodent model

Cardiometabolic and reproductive benefits of early dietary energy restriction and voluntary exercise in an obese PCOS-prone rodent model

Exercise therapy in polycystic ovary syndrome: a systematic review

Lifestyle changes in women with polycystic ovary syndrome

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