Exercise training improves functional recovery and motor nerve conduction velocity after sciatic nerve crush lesion in the rat

Exercício imediato versus tardio na regeneração do nervo isquiático de ratos após axoniotmese: análise histomorfométrica e funcional

“…This is in agreement with several investigators who affirmed that good functional recovery took place over the course of the evaluations, after crushing the sciatic nerve of rats 11,12,24,28 . Therefore, the benefits of physical activity for the denervated animal, such as the increased numbers and diameters of the axons 29 , increased weight, muscle strength, and oxidative capacity of the muscle 10 , rapid return of motor-sensory function during the initial and late phases (thereby accelerating functional recovery) 9 and increased myelinization of the fibers 12 , among others, reaffirmed the importance of investigating and discussing clinical practice. It needs to be taken into account that the induction of neuromuscular activity ( from the applied exercise protocol) in denervated muscles did not impair the process of axon regeneration.…”

“…They state that there must be a resting period before exercise 7 , because muscle atrophy and subsequent reinnervation after sciatic nerve compression in rats becomes evident only between the 14 th and 21 st day after the injury 13 . On the other hand, exercise done during the denervation or immediate phase (one to three days after the nerve injury) accelerates the return of motor-sensory function during the initial phase of recovery 12 and improves functional recovery in rats 9,11,12 . So far, there have been few studies on the influence of exercise on the regeneration process in the injured nerve 12 .…”

“…For this, low-frequency phased electrical stimulation 5 , chronic low-frequency electrostimulation 6 and physical exercise [7][8][9][10][11][12] have been used. Kinesiotherapy is prominent among physical therapy methods for rehabilitation following peripheral nerve injury.…”

Setting the stage for functional repair of spinal cord injuries: a cast of thousands

“…After sciatic nerve crush in rats, both sensory and motor recovery is improved by placing water bottles at heights such that animals have to extend both hind paws maximally to drink; animals with water bottles on the floor do not show improved recovery. 340 There are, however, offsetting data in the same report suggesting that overactivity or stressful regimes such as forced running or swimming can impede rather than enhance functional recovery.…”

Efeito da associação da laserterapia com a natação no reparo morfológico do nervo isquiático e na recuperação funcional de ratos submetidos à axonotmese

“…Several authors have shown beneficial results by using exercise, namely through greater budding and extension of the axons 12 , increased number of myelinated nerve fibers, 13,14 and improved functional recovery of the injured member [15][16][17] . There have been extensive discussions in the scientific community 18 regarding recommendations as per the type of exercise as well as its duration and intensity.…”