Exercise Training Improves Glycemic Control in Long-Standing Insulin-Treated Type 2 Diabetic Patients

Feyter, Henk M. De; Praet, Stephan; Broek, Nicole M. van den; Kuipers, H.; Stehouwer, Coen D. A.; Nicolay, Klaas; Prompers, Jeanine J.; Loon, Luc J. C. van

doi:10.2337/dc07-0183

Cited by 50 publications

(33 citation statements)

References 23 publications

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“…The nature and the risks of the experimental procedures were explained to the subjects and all gave their written informed consent to participate in the study, which was approved by the local Medical Ethical Committee of the Máxima Medical Centre, Veldhoven, The Netherlands. This study is part of a larger project that studies mitochondrial function in chronic metabolic disease (33,34).…”

Section: Subjectsmentioning

confidence: 99%

Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction

Feyter¹,

Broek²,

Praet³

et al. 2008

European Journal of Endocrinology

107

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Objective: Several lines of evidence support a potential role of skeletal muscle mitochondrial dysfunction in the pathogenesis of insulin resistance and/or type 2 diabetes. However, it remains to be established whether mitochondrial dysfunction represents either cause or consequence of the disease. We examined in vivo skeletal muscle mitochondrial function in early and advanced stages of type 2 diabetes, with the aim to gain insight in the proposed role of mitochondrial dysfunction in the aetiology of insulin resistance and/or type 2 diabetes. Methods: Ten long-standing, insulin-treated type 2 diabetes patients, 11 subjects with impaired fasting glucose, impaired glucose tolerance and/or recently diagnosed type 2 diabetes, and 12 healthy, normoglycaemic controls, matched for age and body composition and with low habitual physical activity levels were studied. In vivo mitochondrial function of the vastus lateralis muscle was evaluated from post-exercise phosphocreatine (PCr) recovery kinetics using 31 P magnetic resonance spectroscopy (MRS). Intramyocellular lipid (IMCL) content was assessed in the same muscle using single-voxel 1 H MRS. Results: IMCL content tended to be higher in the type 2 diabetes patients when compared with normoglycaemic controls (PZ0.06). The 31 P MRS parameters for mitochondrial function, i.e. PCr and ADP recovery time constants and maximum aerobic capacity, did not differ between groups. Conclusions: The finding that in vivo skeletal muscle oxidative capacity does not differ between longstanding, insulin-treated type 2 diabetes patients, subjects with early stage type 2 diabetes and sedentary, normoglycaemic controls suggests that mitochondrial dysfunction does not necessarily represent either cause or consequence of insulin resistance and/or type 2 diabetes.European Journal of Endocrinology 158 643-653

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Section: Subjectsmentioning

confidence: 99%

Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction

Feyter¹,

Broek²,

Praet³

et al. 2008

European Journal of Endocrinology

107

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“…A number of studies did not adjust for diabetes duration, insulin use, or diabetes medication, which have been previously implicated as significant risk factors for mortality among individuals with diabetes [8,30–34]. Our analysis included adjustment for demographic and socioeconomic variables, as well as diabetes duration and treatment variables, which were often not included in multivariate models of other studies.…”

Section: Discussionmentioning

confidence: 99%

Physical activity, sedentary behavior and all-cause mortality among blacks and whites with diabetes

Glenn¹,

Slaughter²,

Fowke³

et al. 2015

Annals of Epidemiology

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Purpose The study objective was to examine the role of physical activity (PA) and sedentary time (ST) on mortality risk among a population of low-income adults with diabetes. Methods Black (n = 11,137) and white (n = 4508) men and women with diabetes from the Southern Community Cohort Study self-reported total PA levels and total ST. Participants were categorized into quartiles of total PA and total ST. Hazard ratios (HRs) and 95% confidence intervals (CIs) for subsequent mortality risk were estimated from Cox proportional hazards analysis with adjustment for potential confounders. Results During follow-up, 2370 participants died. The multivariable risk of mortality was lower among participants in the highest quartile of PA compared with those in the lowest quartile (HR, 0.64; 95% CI: 0.57–0.73). Mortality risk was significantly increased among participants in the highest compared with the lowest quartile of ST after adjusting for PA (HR, 1.21; 95% CI: 1.08–1.37). Across sex and race groups, similar trends of decreasing mortality with rising PA and increasing mortality with rising ST were observed. Conclusions Although causality cannot be established from these observational data, the current findings suggest that increasing PA and decreasing ST may help extend survival among individuals with diabetes irrespective of race and sex.

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“…Combined aerobic and resistance training improves glycemic control in individuals with type 2 diabetes, even if they have been taking insulin for extended periods of time (De Feyter et al, 2007). Such research is promising as it shows the benefits of exercise can be achieved by those with varying severities of type 2 diabetes.…”

Section: Glycemic Controlmentioning

confidence: 99%

“…lesser improvements over very similar periods of time (De Feyter et al, 2007;Ibanez et al, 2005;Tokmakidis et al, 2004). It is important to note that strength gains can be maintained with a structured home-based resistance training program following an initial structured community-based program (Dunstan et al, 2005).…”

Section: Body Compositionmentioning

confidence: 99%

Physical Activity Supports Provided by Healthcare Providers to Patients with Type 2 Diabetes

Hnatiuk

Duhamel

Katz

et al. 2012

Canadian Journal of Diabetes

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Exercise Training Improves Glycemic Control in Long-Standing Insulin-Treated Type 2 Diabetic Patients

Cited by 50 publications

References 23 publications

Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction

Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction

Physical activity, sedentary behavior and all-cause mortality among blacks and whites with diabetes

Physical Activity Supports Provided by Healthcare Providers to Patients with Type 2 Diabetes

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