Exercise Training Improves Whole Body Insulin Resistance via Adiponectin Receptor 1

Cho, J.-K.; Kim, S.-U.; Hong, Hye-ryun; Yoon, Jin hwan; Kang, Hyunah

doi:10.1055/s-0035-1569357

Cited by 6 publications

(4 citation statements)

References 39 publications

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“…In line with this, Simpson and Singh reported in their review that adiponectin expression levels are increased under high-intensity exercise conditions [ 91 ], regardless of training modality in untrained young lean or obese individuals, after chronic whole-body strength training or jogging [ 92 , 93 ]. In line with this, Cho et al showed that 40 minutes of HIT exercise on treadmill prevent the downregulation of AdipoR1 which was caused by a high fat diet in sedentary control animals [ 94 ] indicating the importance of intense training for the potential role of adiponectin.…”

Section: Inflammation-associated Signaling Pathways and Key Playermentioning

confidence: 85%

Influence of Acute and Chronic Exercise on Glucose Uptake

Röhling

Herder

Stemper

et al. 2016

Journal of Diabetes Research

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Insulin resistance plays a key role in the development of type 2 diabetes. It arises from a combination of genetic predisposition and environmental and lifestyle factors including lack of physical exercise and poor nutrition habits. The increased risk of type 2 diabetes is molecularly based on defects in insulin signaling, insulin secretion, and inflammation. The present review aims to give an overview on the molecular mechanisms underlying the uptake of glucose and related signaling pathways after acute and chronic exercise. Physical exercise, as crucial part in the prevention and treatment of diabetes, has marked acute and chronic effects on glucose disposal and related inflammatory signaling pathways. Exercise can stimulate molecular signaling pathways leading to glucose transport into the cell. Furthermore, physical exercise has the potential to modulate inflammatory processes by affecting specific inflammatory signaling pathways which can interfere with signaling pathways of the glucose uptake. The intensity of physical training appears to be the primary determinant of the degree of metabolic improvement modulating the molecular signaling pathways in a dose-response pattern, whereas training modality seems to have a secondary role.

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Section: Inflammation-associated Signaling Pathways and Key Playermentioning

confidence: 85%

Influence of Acute and Chronic Exercise on Glucose Uptake

Röhling

Herder

Stemper

et al. 2016

Journal of Diabetes Research

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“…Also, resistance training improved insulin signaling in skeletal muscle of T2D rats 62 . Cho et al revealed that exercise training improves whole body insulin resistance via APNR1 63 . Furthermore, some researches showed that acute physical exercise increases adiponectin signaling in the hypothalamus of lean mice 64 , 65 .…”

Section: Discussionmentioning

confidence: 99%

Adiponectin receptor 1 could explain the sex differences in molecular basis of cognitive improvements induced by exercise training in type 2 diabetic rats

Rajizadeh,

Moslemizadeh,

Hosseini

et al. 2023

Sci Rep

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Adipokines dysregulation, the main reason for cognitive impairments (CI) induced by diabetes, shows a sex-dependent pattern inherently and in response to exercise. This study aimed to compare the attenuating effect of 8-week high intensity-interval training (HIIT) on type 2 diabetes (T2D)-induced CI between male and female rats with a special focus on adiponectin and leptin. 28 male & 28 female Wistar rats with an average age of 8 weeks were randomly assigned into four groups: control (Con), exercise (EX), Diabetes (T2D), and Type 2 diabetes + exercise (T2D + Ex). Rats in EX and T2D + EX groups performed HIIT for eight weeks (80–100% Vmax, 4–10 intervals). T2D was induced by 2 months of a high-fat diet and a single dose of STZ (35 mg/kg) administration. Leptin and adiponectin levels in serum were measured along with hippocampal expression of leptin and adiponectin receptors, AMP-activated protein kinase (AMPK), dephosphorylated glycogen synthase kinase-3 beta (Dep-GSK3β), Tau, and beta-amyloid (Aβ). Homeostasis model assessments (HOMAs) and quantitative insulin-sensitivity check index (QUICKI) indices were calculated. Our results showed that following T2D, serum levels of APN, and hippocampal levels of adiponectin receptor 1 (APNR1) were higher and HOMA-IR was lower in female than male rats (P < 0.05). However, after 8 weeks of HIIT, hippocampal levels of APNR1 and AMPK as well as QUICKI were lower and hippocampal levels of GSK, Tau, and Aβ were higher in females compared to male rats (P < 0.05). While the risk of CI following T2D was more in male than female rats HIIT showed a more ameliorating effect in male animals with APN1 as the main player.

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“…Nowadays, it is known both in experimental or human models that physical exercise is an important modulator of proteins involved in adiponectin signaling (Farias et al., ; Marinho et al., ; Van Berendoncks et al., ). Despite the well‐established effects of exercise on adiponectin signaling in peripheral tissues (Cho, Kim, Hong, Yoon, & Kang, ), we have recently observed that obese animals showed a decrease in APPL1 in the hypothalamus and physical exercise reversed this damage by leptin stimulation (Gaspar et al., ). Thus, the present study corroborates with the data previously observed with the obese experimental models.…”

Section: Discussionmentioning

confidence: 82%

Acute physical exercise increases APPL1/PI3K signaling in the hypothalamus of lean mice

Gaspar

Muñoz

Kuga

et al. 2019

Eur J of Neuroscience

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Adiponectin is an adipokine that acts in the control of energy homeostasis. The adaptor protein containing the pleckstrin homology domain, phosphotyrosine-binding domain, and leucine zipper motif 1 (APPL1) is a key protein in the adiponectin signaling. The APPL1 mediates a positive effect on the insulin signaling through the interaction with the phosphoinositide 3-kinase (PI3K). Thus, the present study aimed to explore the effects of an acute physical exercise session on the hypothalamic adiponectin signaling. Firstly, using bioinformatics analysis, we found a negative correlation between hypothalamic APPL1 mRNA levels and food consumption in several strains of genetically diverse BXD mice. Also, the mice and the human database revealed a positive correlation between the levels of APPL1 mRNA and PI3K mRNA. At the molecular level, the exercised mice showed increased APPL1 and PI3K (p110) protein contents in the hypothalamus of Swiss mice. Furthermore, the exercise increases co-localization between APPL1 and PI3K p110 predominantly 3182 | GASPAR et Al.

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Exercise Training Improves Whole Body Insulin Resistance via Adiponectin Receptor 1

Cited by 6 publications

References 39 publications

Influence of Acute and Chronic Exercise on Glucose Uptake

Influence of Acute and Chronic Exercise on Glucose Uptake

Adiponectin receptor 1 could explain the sex differences in molecular basis of cognitive improvements induced by exercise training in type 2 diabetic rats

Acute physical exercise increases APPL1/PI3K signaling in the hypothalamus of lean mice

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