Exercise Training in Heart Failure

Rubin, Stanley A.

doi:10.1016/j.jacc.2007.04.013

Cited by 5 publications

(3 citation statements)

References 27 publications

(18 reference statements)

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“…Moreover, the authors noticed a significant reduction in the microvascular density in patients’ with CHF without major differences in other histologic and biochemical aerobic markers [53]. The skeletal muscle dysfunction in heart failure is due to atrophy of muscle fibre, a relative decrease in oxidative type-I fibres, loss of microvasculature, decrease in enzymes of oxidative metabolism, and attenuation of mitochondrial surface density and size [3, 30]. ET has been shown in part to correct the skeletal muscle abnormalities in these patients.…”

Section: Exercise Training and Improvement Of Skeletal Muscle Functionmentioning

confidence: 99%

“…CHF is characterized by the inability of heart muscle to meet tissue energy demand that results in symptoms of fatigue or dyspnoea initially on exertion and then later on progressing to even at rest [1-2]. Actually, ventricular dysfunction is usually the major component of the CHF syndrome, which occurs in conjunction with skeletal muscle structural and functional abnormalities [3-4]. There is also a perception that the underlying mechanisms are largely dependent on oxidative energy production and control of energy fluxes [3-4].…”

Section: Introductionmentioning

confidence: 99%

“…Actually, ventricular dysfunction is usually the major component of the CHF syndrome, which occurs in conjunction with skeletal muscle structural and functional abnormalities [3-4]. There is also a perception that the underlying mechanisms are largely dependent on oxidative energy production and control of energy fluxes [3-4]. Likewise, dyspnoea appears to be more closely related to increased ventilatory effort than pulmonary congestion, a feature that varies between patients [5-6].…”

Section: Introductionmentioning

confidence: 99%

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Current Concepts Underlying Benefits of Exercise Training in Congestive Heart Failure Patients

Elahi

Mahmood²,

Ahmad³

et al. 2010

CCR

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The pathophysiology of several conditions including heart failure is partly attributable to a failure of the cell energy metabolism. Studies have shown that exercise training (ET) improves quality of life (QOL) and is beneficial in terms of reduction of symptoms, mortality and duration of hospitalization. Increasingly, ET is now achieving acceptance as complimentary therapy in addition to routine clinical practice in patients with chronic heart failure (CHF). However, the mechanisms underlying the beneficial effects of ET are far less understood and need further evaluation. Evidence suggests that while CHF induces generalized metabolic energy depletion, ET largely enhances the overall function of the heart muscle. Hence, research efforts are now aiming to uncover why ET is beneficial as a complimentary treatment of CHF in the context of improving endothelial function and coronary perfusion, decreasing peripheral resistance, induction of cardiac and skeletal muscle cells remodeling, increasing oxygen uptake, substrate oxidation, and resistance to fatigue. Here we discuss the current evidence that suggest that there are beneficial effects of ET on cardiac and skeletal muscle cells oxidative metabolism and intracellular energy transfer in patients with CHF.

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Section: Exercise Training and Improvement Of Skeletal Muscle Functionmentioning

confidence: 99%