Exercise Training in Patients With Non–Small Cell Lung Cancer During In-Hospital Chemotherapy Treatment

Rutkowska, Anna; Jastrzębski, Dariusz; Rutkowski, Sebastian; Żebrowska, Aleksandra; Stanula, Arkadiusz; Szczegielniak, Jan; Casaburi, Richard

doi:10.1097/hcr.0000000000000410

Cited by 51 publications

(93 citation statements)

References 53 publications

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“…[70,74]. Regarding exercise, patients with advanced cancer who can complete an exercise program show improvements in physical function and QOL [75][76][77][78][79][80][81][82][83], and the ESMO guidelines recommend resistance exercise 2-3 times per week if possible for patients with cachexia [26]. In Japan and abroad, clinical trials of multidisciplinary interventions combining nutritional and exercise therapies have been conducted, and their efficacy and safety have been verified [83][84][85][86][87][88].…”

Section: Clinical Evidence For the Treatment Of Cancer Cachexiamentioning

confidence: 99%

Cancer Cachexia: Its Mechanism and Clinical Significance

Nishikawa

Goto

Fukunishi

et al. 2021

IJMS

140

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The term “cachexia” is derived from the Greek words kakos (bad) and hexis (habit). Cachexia is a malnutrition associated with chronic diseases such as cancer, chronic heart failure, chronic renal failure, and autoimmune diseases, and is characterized by decreased skeletal muscle mass. Cancer cachexia is quite common in patients with advanced cancer. Weight loss is also a characteristic symptom of cancer cachexia, along with decreased skeletal muscle mass. As nutritional supplementation alone cannot improve cachexia, cytokines and tumor-derived substances have been attracting attention as its relevant factors. Cancer cachexia can be also associated with reduced chemotherapeutic effects, increased side effects and treatment interruptions, and even poorer survival. In 2011, a consensus definition of cachexia has been proposed, and the number of relevant research reports has increased significantly. However, the pathogenesis of cachexia is not fully understood, and there are currently few regulatory-approved standard treatments for cachexia. The main reason for this is that multiple etiologies are involved in the development of cachexia. In this review, we will outline the current status of cachexia, the mechanisms of which have been elucidated in recent years, especially from the perspective of advanced cancer.

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Section: Clinical Evidence For the Treatment Of Cancer Cachexiamentioning

confidence: 99%

Cancer Cachexia: Its Mechanism and Clinical Significance

Nishikawa

Goto

Fukunishi

et al. 2021

IJMS

140

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“…[2][3][4][5][6] Traditional programs of pulmonary rehabilitation have been shown to be capable of at least partially reversing muscle dysfunction and improving mobility; it is the most effective therapy to improve exercise tolerance in chronic respiratory diseases, 7,8 idiopathic pulmonary fibrosis, 9 and lung cancer. 10 However, in international surveys, traditional pulmonary rehabilitation is available to only a small fraction of COPD patients. 11 Alternate modes of rehabilitation are sought which might increase availability to patients who would benefit.…”

Section: Introductionmentioning

confidence: 99%

<p>Virtual Reality Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial</p>

Rutkowski¹,

Rutkowska²,

Kiper³

et al. 2020

COPD

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This study compared the effects of inpatient-based rehabilitation program of patients with chronic obstructive pulmonary disease (COPD) using non-immersive virtual reality (VR) training with a traditional pulmonary rehabilitation program. The aims of this study were to determine 1) whether rehabilitation featuring both VR as well as exercise training provides benefits over exercise training (ET) alone and 2) whether rehabilitation featuring VR training instead of exercise training provides equivalent benefits. Patients and Methods: The study recruited 106 patients with COPD to a 2-week highintensity, five times a week intervention. Randomized into three groups, 34 patients participated in a traditional pulmonary rehabilitation program including endurance exercise training (ET), 38 patients participated in traditional pulmonary rehabilitation, including both endurance exercise training and virtual reality training (ET+VR) and 34 patients participated in pulmonary rehabilitation program including virtual reality training but no endurance exercise training (VR). The traditional pulmonary rehabilitation program consisted of fitness exercises, resistance respiratory muscle and relaxation training. Xbox 360 ® and Kinect ® Adventures software were used for the VR training of lower and upper body strength, endurance, trunk control and dynamic balance. Comparison of the changes in the Senior Fitness Test was the primary outcome. Analysis was performed using linear mixed-effects models. Results: The comparison between ET and ET+VR groups showed that ET+VR group was superior to ET group in Arm Curl (p<0.003), Chair stand (p<0.008), Back scratch (p<0.002), Chair sit and reach (p<0.001), Up and go (p<0.000), 6-min walk test (p<0.011). Whereas, the comparison between ET and VR groups showed that VR group was superior to ET group in Arm Curl (p<0.000), Chair stand (p<0.001), 6-min walk test (p<0.031). Conclusion: Results suggest that pulmonary rehabilitation program supplemented with VR training is beneficial intervention to improve physical fitness in patients with COPD.

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“…During the weekend, patients were encouraged to go for walks and engage in minor physical activity on their own, but during this time they did not take advantage of the organized rehabilitation (non-supervised days). This program has been found to exhibit clinically meaningful improvements in exercise capacity, dyspnea, quality of life, and lung function in patients with COPD [ 40 , 41 ] or lung cancer [ 42 , 43 ]. All procedures were performed under the supervision of a specialist with an M.Phty.…”

Section: Methodsmentioning

confidence: 99%

Monitoring Physical Activity with a Wearable Sensor in Patients with COPD during In-Hospital Pulmonary Rehabilitation Program: A Pilot Study

Rutkowski

Buekers

Rutkowska

et al. 2021

Sensors

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Accelerometers have become a standard method of monitoring physical activity in everyday life by measuring acceleration in one, two, or three axes. These devices provide reliable and objective measurements of the duration and intensity of physical activity. We aimed to investigate whether patients undertake physical activity during non-supervised days during stationary rehabilitation and whether patients adhere to the rigor of 24 h monitoring. The second objective was to analyze the strengths and weaknesses of such kinds of sensors. The research enrolled 13 randomly selected patients, qualified for in-patient, 3 week, high-intensity, 5 times a week pulmonary rehabilitation. The SenseWear armband was used for the assessment of physical activity. Participants wore the device 24 h a day for the next 4 days (Friday–Monday). The analysis of the number of steps per day, the time spent lying as well as undertaking moderate or vigorous physical activity (>3 metabolic equivalents of task (METs)), and the energy expenditure expressed in kcal showed no statistically significant difference between the training days and the days off. It seems beneficial to use available physical activity sensors in patients with chronic obstructive pulmonary disease (COPD); measurable parameters provide feedback that may increase the patient’s motivation to be active to achieve health benefits.

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Exercise Training in Patients With Non–Small Cell Lung Cancer During In-Hospital Chemotherapy Treatment

Cited by 51 publications

References 53 publications

Cancer Cachexia: Its Mechanism and Clinical Significance

Cancer Cachexia: Its Mechanism and Clinical Significance

<p>Virtual Reality Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial</p>

Monitoring Physical Activity with a Wearable Sensor in Patients with COPD during In-Hospital Pulmonary Rehabilitation Program: A Pilot Study

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